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Research Themes - 265 Result(s)

 E

Establishment of Minimally Invasive Cell Therapy for Diabetes by Introducing Interdisciplinary Approach

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特徴・独自性
  • The islet transplantation is the ideal "minimum invasive" cell transplant therapy for the severe diabetic patients who are suffering with controlling the blood glucose levels. In this project, we try to have a cross organization among the advanced technologies in islet transplantation as one of the typical cases. Our chief objective is to construct the center of medical cell-engineering therapy as successful examples in Tohoku University. We are convinced that technical innovation through this project could contribute much more to the activation of medical industry based upon cell therapy.
実用化イメージ

We have already established effective academic-industrial alliances regarding our several projects including a development of new type of cell-isolation enzyme. However, we are still looking for possible candidates concerning a special device for cell transplantation and medical grade-pathogen free animals.

Researchers

Graduate School of Medicine

Masafumi Goto

Exercising "Cultured" Myotubes!

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特徴・独自性
  • We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).
実用化イメージ

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Researchers

Graduate School of Biomedical Engineering

Makoto Kanzaki

 F

Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation Techniques

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特徴・独自性
  • The emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding.
実用化イメージ

The method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for.

Researchers

Graduate School of Engineering

Noritaka Yusa

Fabrication of The Novel Designed Nanodrugs Composed of Poorly Water-Soluble Compounds

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特徴・独自性
  • One of our major research focuses is to design the novel drug nanoparticles, so called “Nano-prodrugs”, and to apply them as anticancer drugs or eye drops with excellent delivery efficiency. Nano-prodrugs are constructed by synthetic prodrugs molecules which contains poorly water-soluble substituent. They could be fabricated to nanoparticles with 100 nm or less in size by our reprecipitation technique, which has been used to create organic nanomaterials. We are aiming at practical application of our Nano-prodrugs in the near future.
実用化イメージ

Our reprecipitation technique for fabricating organic nanomaterials is a versatile technique that can be applied to various organic molecules as well as drug compounds. We hope to conduct collaborative research with a willing company on controlling and evaluating properties of the organic nanoparticles.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Hitoshi Kasai

Food Palatability, Product Usability, and Preference; An Approach from Psychology and Neuroscience.

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特徴・独自性
  • My research interest is peoples' perception of external stimulus. Based on these researches and our knowledge, I can offer you an idea of the products that give consumers satisfaction. Also on the basis of psychological and neuro-scientifc experiences and knowledges, I can offer you a transdisciplinary approaches on human perception, cognition, emotion and decision making.
実用化イメージ

Marketing and developing of the products such as foods, beverages, fabric softeners, perfumes, body deodorants etc. The knowledges and research tools are also useful in regulating the malodor in the air pollution, in developing the public services and in elevating public quality of life.

Researchers

Graduate School of Arts and Letters

Nobuyuki Sakai

Forecasting eruption transition through geologic and petrologic approaches

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特徴・独自性
  • 1) In addition to geophysical observations, recent advances in volcanic stratigraphy and petrology would make us possible to forecast the transition of volcanic eruptions. We have been developing near-real-time volcanology based on the erupted materials in an early eruption stage.
  • 2) Automation of textural analyses of erupted materials, Risk assessment of volcanic eruption based on eruption stratigraphy
実用化イメージ

Researchers

Graduate School of Science

Michihiko Nakamura

Fuel Cell and Energy Storage Using Ion Conduction in Ceramics

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特徴・独自性
  • Solid oxide fuel cell is a highly efficient power generation system operating at high temperatures using ion conducting ceramics. We conduct basic and multi-aspect research on the electrochemical and mechanical behaviors of the materials for further improving the efficiency, cost, and reliability of solid oxide fuel cells. We are also interested in the reverse operation of fuel cells which enables the storage of the electricity from renewable sources into hydrogen or methane, etc.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Tatsuya Kawada

Functional and Molecular Imaging with Positron Emission Tomography (PET)

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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Cyclotron and Radioisotope Center

Manabu Tashiro

Functional Uniform Nanoparticles Production and Their Industrial Use

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特徴・独自性
  • Nanoparticles and/or fine particles to be used for functional materials, such as semiconductor, photocatalysts, dielectric and/or piezoelectric materials, cosmetics, catalysts, etc., has been synthesized in liquid-phase. Their size, shape, composition, and structure have been <strong>precisely controlled</strong> along an expected usage. <strong>Tailor-made synthesis method</strong> has been provided for nanoparticles and/or fine particles the companies wish to use.
実用化イメージ

Until now, we have been supplying nanoparticles and/or fine particles of ITO (Indium Tin Oxides) as TCO, Bi based or Nb based particles for lead-free piezoelectric ceramics, perovskite-based oxides for dielectric materials etc. The gel-sol method as the main synthesis method for uniform particles makes the production cost reduced.

Researchers

International Center for Synchrotron Radiation Innovation Smart

Atsushi Muramatsu

 G

Gastroenteritis virus-binding enteric bacteria for probiotics

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特徴・独自性
  • We have found enteric bacteria that can capture gastroenteritis viruses, such as norovirus and rotavirus, through histo-blood group antigen (HBGA)-like substances. These HBGA-positive bacteria give a significant impant on the ecology of gastroenteritis viruses in human body and in environments.
実用化イメージ

Since gastroenteritis virus-binding bacteria can affect the viral infection capability to host cells, these bacteria and produced HBGA-like substances are available in probiotics application.

Researchers

Graduate School of Engineering

Daisuke Sano

Generation of Rice Plants Suitable for Biofuel Production

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特徴・独自性
  • To generate a rice plant suitable for efficient biofuel production from its straw, we examined effects of overexpression of cellulase on saccharification of straw. The transgenic plant constitutively overexpressing cellulase showed enhanced saccharification, but various physiological and morphological abnormalities were also observed. To overcome this problem, a senescence-inducible promoter was used to express the cellulase. The plants successfully avoided the problem and showed enhanced saccharification after senescence.
実用化イメージ

Rice straw will be an efficient material for biofuel production. This method can be applied to other plants. In combination with highly engineered microorganisms for saccharification and fermentation, this method will contribute to efficient production of biofuels.

Researchers

Graduate School of Agricultural Science

Yukihiro Ito

newGlass that conducts heat well

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概要

We aim to give high thermal conductivity to glass, which is known as a material that does not conduct heat well, and to apply it to new fields.

従来技術との比較

If mixed with a high thermal conductive material, glass can be a good conductor of heat. However, all the advantages of glass, such as transparency and freedom of molding, are lost. In this research, we succeeded in developing a transparent glass with high thermal conductivity that retains its glassiness by adopting the strategies of high thermal conductivity MgO deposition and refractive index matching.

特徴・独自性
  • Transparent
  • Free molding
  • Thermal conductivity ~ 3 W/(m K) [300% of that of window glass]
実用化イメージ

Heat dissipation management using glass [heat dissipating glass substrates, lenses, fibers, etc.]

Researchers

Graduate School of Engineering

Nobuaki Terakado

 H

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

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概要

We offer shared facility for the development of semiconductor prototypes equipped with 4-inch, 6-inch and some 8-inch wafer fabrication tools available on an hourly basis. Know-how accumulated at Tohoku University is available, and staff provide maximum support for prototyping. The service is performed at the 1,200 m2 Super Clean Room on the second floor of the Junichi Nishizawa Memorial Research Centre at Tohoku University. For information on equipment and fees, see our website.

従来技術との比較

More than 10 experienced technical staff assist customer's usages. Standard process conditions for each process, such as etching and deposition, are provided. allowing customers to start prototyping immediately. Various materials other than silicon can also be supported.

特徴・独自性
  • We support the development of devices and semiconductor materials such as MEMS, optical elements and RF components.
  • Technical consultation on devices and processes before and during prototyping is also available.
  • A
  • 'Prototype lab' for device packaging is also available.
  • The museums where you can learn about the history of semiconductors, measuring instruments and sensors are open.
  • As part of Technology Co-creation for Semiconductor of Tohoku University, we promote R&D of semiconductors and the development of human resources.
  • On-demand semiconductor human resource development programs for students and engineers are available.
  • As a member of the MEXT's Advanced Research Infrastructure for Materials (ARIM) program, we are involved in sharing facility and data.
実用化イメージ

More than 310 companies have used our shared facility since its launch in 2010, not only from device manufacturers such as MEMS, but also from manufacturers of materials, mechanical components and equipment. To date, we have successfully supported the commercialization of about 10 devices.

Researchers

Micro System Integration Center

Kentaro Totsu

Hardware Development of Brain Computer and its Application to Visual Information Processing

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特徴・独自性
  • Toward realizing a high-performance neuromorphic vision processing system, our research involves a neural network model of spatial perception based on motion-stereo vision and its implementation on a very large scale integrated circuit (VLSI). Important parameters for spatial perception such as time-to-contact, orientation, and the shortest distance to plane surfaces of a target object are recognized by using the model without knowing moving direction and velocity of the object. We have developed a VLSI capable of performing visual perception based on the model with low power consumption, reduced less than 1/100 compared with a commercial CPU.
実用化イメージ

Targeted applications include a drone flying autonomously equipped with collision avoidance system by visual perception. Targeted industry includes infrastructure inspection, agriculture, logistics, and so on.

Researchers

Research Institute of Electrical Communication

Shigeo Sato

High Performance Computer Architectures and their Applications

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特徴・独自性
  • My research interests include the design and development of high-performance supercomputing systems and their applications. Targeted areas range from the key components of supercomputing systems, which include processor architectures, memory subsystems, network systems, task schedulers, and compilers, to high-performance multimedia processing algorithms such as photo-realistic computer graphics.
実用化イメージ

Currently I am conducting joint-research projects with several companies in the fields of high-performance computer architecture design and advanced simulation technologies for industrial design such as next-generation supercomputers and highly efficient and comfortable regional jets.

Researchers

Graduate School of Information Sciences

Hiroaki Kobayashi

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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特徴・独自性
  • Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.
実用化イメージ

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Researchers

Research Center for Neutrino Science

Kunio Inoue

High-Precision Capturing of 3-D Dental-Arch Shapes and Their Occlusal Relation and its Potential Implementation into CAD/CAM Dentistry

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特徴・独自性
  • In spite of the long history of digital dentistry, the accuracy of the prosthetics fabricated with CAD/CAM systems is far from satisfactory. Jaw opening during taking impression elicits deformation of the mandible and the lower dental arch, and consequently causes the inaccuracy of occlusal relationship of the upper and lower dental arches on the CAD data. The method presented here utilizes the check-bite record at the maximum intercuspation to correct the relative positions among the teeth in the dental arches as well as between the arches. After this correction, the accuracy of the CAD data is satisfactory enough for the fabrication of the dental prosthetics which need no adjustment during their setting.
実用化イメージ

This method uses the newly-developed check-bite recording technique together with the conventional precious impression or optical impression techniques. It can easily be applied to the commercial CAD/CAM systems in the market. We hope to collaborate to the manufacturers of dental CAD/CAM systems to increase the accuracy of the systems.

Researchers

Graduate School of Dentistry

Yoshinori Hattori

High-speed and low-power asynchronous Network-on-Chip system based multiple-valued current-mode logic

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特徴・独自性
  • Global intra-chip interconnection complexity not only limits the clock frequency, but causes clock-skew problems in synchronous system. Asynchronous control-based circuit design, where timing is managed locally, is one of the possible approaches to solve the above serious interconnection problem because the asynchronous design has many features which are low power dissipation, high speed and robustness. However, communication-steps overhead caused by handshaking much would generally affect the cycle time.
  • In our approach, a high-speed asynchronous data-transfer scheme is proposed based on multiple-valued encoding and current-mode circuits. The multiple-valued encoding enables to improve communication protocol essentially. Moreover, the current-mode circuits which has high-driving capability makes it possible to perform high-speed intra- and inter-chip network. By using this method, we expect that we can conduct effective collaborative research in high-speed and low-power communication LSIs such as a many-core LSI and a multi-module NoC.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Takahiro Hanyu

High-Speed Vision for Real-Time Motion Analysis

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特徴・独自性
  • We are investigating high-speed vision systems that enable real-time image acquisition and visual processing at frame rates substantially higher than the standard video rate.
実用化イメージ

High-speed vision systems are useful for fast measurement and control of dynamic systems in general. When combined with external facilities such as high-speed projectors or acceleration sensors, they enable further wider applications including fast 3D measurement or object identification.

Researchers

Graduate School of Information Sciences

Shingo Kagami

High-speed X-ray phase tomography with a millisecond-order temporal resolution

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特徴・独自性
  • We successfully realized millisecond-order X-ray phase tomography using a fringe-scanning method in grating-based X-ray interferometry. We obtained phase tomograms with a measurement time of 4.43 ms using a white synchrotron X-ray beam. The use of a fringe-scanning method enables us to achieve not only a higher spatial resolution but also a higher signal-to-noise ratio than that attained by the Fourier transform method. In addition, our approach can be applied to realize four-dimensional or high-throughput X-ray tomography for samples that can be rotated at a high speed.
実用化イメージ

Researchers

International Center for Synchrotron Radiation Innovation Smart

Wataru Yashiro