"A" Keywords - 75 Result(s)

 A

[ABC transporter]

Regulation of ABC Transporters in Colorectal Cancer

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特徴・独自性
  • Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.
実用化イメージ

Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.

Researchers

Graduate School of Medicine

Keiko Nakayama

[acceleration sensor]

Assessment of Physical Activities Using Wearable Sensors

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特徴・独自性
  • Maintaining appropriate amount of physical activity is essential for health and disease prevention. Gait is the most common type of physical activity in everyday life. Monitoring the amount of physical activity in everyday lives may benefit mainly those who are at threat of metabolic syndrome and overweight. Towards better estimation of the amount of physical activity utilizing wearable sensors, we focused on taking running and walking economy into account. The relationship between step length and oxygen uptake was first determined. Step length estimation with moderate accuracy was accomplished using acceleration signals during walking. Step length was then taken into energy expenditure calculation as one of the variables.
実用化イメージ

Together with the basic version of the current locomotion monitoring system capable of counting staircase climbing up & down, we managed to upgrade our locomotion monitoring system into 3 dimensional.

Researchers

Graduate School of Biomedical Engineering

Ryoichi Nagatomi

[access control]

Network Roaming System with Flexible Access Control

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特徴・独自性
  • The laboratory works on development of authentication wireless LAN systems which refer user attribute to realize flexible access control capability.Improvement and evaluation of new access control is devised based on experience of operation of an international wireless lan roaming service ‘eduroam' which is based on 802.1x authorization protocol.
実用化イメージ

The development contains application of OpenFlow technology to select a connecting network depending on user affiliation, as well as access control based on pre-defined attribute information.

Researchers

Organization for Innovations in Data Synergy

Hideaki Sone

[acoustic power]

Understanding and application of thermoacoustic phenomena

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特徴・独自性
  • Acoustic oscillations of a gas column in narrow flow channels can lead to various thermal phenomena such as production and amplification of acoustic power from heat and generation of low temperatures. We aim at understanding these thermoacoustic phenomena from experimental point of view, and developing heat engines that can operate without any moving parts like solid pistons.
実用化イメージ

Acoustic prime mover can use various heat sources like industrial waste heat and sunlight. Acoustic cooler is a Helium-gas based heat pump that needs no Freon gases as a coolant.

Researchers

Graduate School of Engineering

Tetsushi Biwa

[Acoustic reconance]

Dry-Contact Ultrasonic Technique

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特徴・独自性
  • A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering Department of Finemechanics

TOHMYOH Hironori

[Acoustic resonator]

MEMS/Micromachines and Microfabrication Technology

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特徴・独自性
  • We are studying MEMS (Micro Electro Mechanical Systems) and related technologies, which are typically used for the input/output of information/communication devices, the safety of automobiles etc. Our representative topics include integrated sensors, piezoelectric devices, RF MEMS, micro energy devices and wafer-level packages. Our facilities are open-accessible and well equipped with a lot of tools for lithography, dry/wet etching, thin film deposition, wafer bonding, device mounting and evaluations, which can be operated by each researcher. Using these tools, a variety of MEMS are being prototyped. Also, new microfabrication tools are being developed by ourselves.
実用化イメージ

We are collaborating with many companies, from which visiting researchers are dispatched to our laboratory. We also accept companies which want to just use specific tools in our facilities. Consultation is always welcome.

Researchers

Graduate School of Engineering

Shuji Tanaka

[Actuator]

MEMS/Micromachines and Microfabrication Technology

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特徴・独自性
  • We are studying MEMS (Micro Electro Mechanical Systems) and related technologies, which are typically used for the input/output of information/communication devices, the safety of automobiles etc. Our representative topics include integrated sensors, piezoelectric devices, RF MEMS, micro energy devices and wafer-level packages. Our facilities are open-accessible and well equipped with a lot of tools for lithography, dry/wet etching, thin film deposition, wafer bonding, device mounting and evaluations, which can be operated by each researcher. Using these tools, a variety of MEMS are being prototyped. Also, new microfabrication tools are being developed by ourselves.
実用化イメージ

We are collaborating with many companies, from which visiting researchers are dispatched to our laboratory. We also accept companies which want to just use specific tools in our facilities. Consultation is always welcome.

Researchers

Graduate School of Engineering

Shuji Tanaka

Design, fabrication and test of high performance miniaturized sensor and actuator systems

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特徴・独自性
  • Micro and nano electro-mechanical systems (MEMS/NEMS) have completely changed human society in the past decades. Many devices that are taken for granted these days like smart phone, future car and drone would be unthinkable without them.
  • The integration of various new kinds of materials, such as metallic glass and nanostructures into micro technologies allows us to create devices with novel performance and characteristics; examples include acoustic sensors and actuators, thermoelectric generators and wafer level packages.
  • In collaboration with partners inside and outside Tohoku University, technologies are being developed that can be transferred to industry ranging from material integration and processes to packaging and reliability.
実用化イメージ

Wide collaboration in Microsystem technology is possible. We develop, implement and optimize processes, devices and systems until they are ready for use, keeping in mind reliability, yield and other important features for commercialization. We work with also with partners, such as Fraunhofer. Flexible interlinking of expertise and capacities with other research groups enables us to meet broad project requirements and create complex system solutions.

Researchers

Micro System Integration Center

Froemel Joerg Eckhardt

[Additive manufacturing]

Additive Manufacturing of Metallic Parts with Electron Beam Melting (EBM)

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特徴・独自性
  • Electron beam melting (EBM) is a type of additive manufacturing technologies. EBM uses electron beam as an energy source to melt metal powder and produce metal thin layers. This sequence is repeated in a layer-by-layer manner to fabricate three-dimensional (3D) components.
  • This technology can produce any kinds of structures based on 3D CAD models and is suitable for custom-made manufacturing.
  • In addition, our recent studies revealed that the unique microstructure, such as directional solidification and uniform dispersions of fine precipitates, are obtained by EBM; this technology is useful to realize advanced materials that cannot be obtained conventional manufacturing.
実用化イメージ

The EBM technology has received much attention for producing metal parts used in biomedical, aerospace and automotive industries.
Rapid prototyping / rapid tooling is one of the applications of this technology.

Researchers

New Industry Creation Hatchery Center

Akihiko Chiba

[adipose tissue]

INSTRUMENT AND METHOD FOR ANALYZING METABOLIC CONDITION OF LIVING BODY AND RECORDING MEDIUM

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特徴・独自性
  • AIMS: The invention is to analyze metabolic condition, especially in oxygen consumption and energy production in the adipose tissues of human (Patent: JP 3848818).
  • PROBLEM TO BE SOLVED: To provide an instrument and method for analyzing the metabolism condition of a living body which is constructed in such a manner that it can measure the metabolism condition of a living body correctly and easily, and a recording medium.
  • SOLUTION: A metabolism condition analyzer is provided with an input means for inputting information about the body of a subject, a control means for processing this information and an output means for outputting results of the processing. The information consists of name, age, sex, race, height, weight, bioelectric resistance value and the date and time of measurement. A data file consisting the control means stores evaluation data of a metabolic condition which is previously determined by medical judgment based on a combination of an internal respiration index and oxygen consumption and energy production in adipose tissues. These are computed by calculating the value obtained by subtracting one from a body density calculated from the height, weight of the subject and the bioelectric resistance value and then multiplying the value. Welcome to your investment or co-operation.
実用化イメージ

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[adsorption/desorption]

Selective recovery of tocotrienol from vegetable oils using ion-exchange resins

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特徴・独自性
  • Tocotrienol, one of vitamin E, has recovered by the conventional method with molecular distillation from deodrizer distillate discharged from the oil refining processes. However, tocotrienol easily loses its activity due to its low thermal stability, so that its recovery ratio and purity were extremely low. We proposed a novel method to selectively recover tocotrienol by adsorption/desorption using anion-exchange resin at 50 degree C. Tocotrienol is retained on the resin by ion-exchange reaction, and then released and recoverd from the resin by other ion-exchange reaction. Prior to the adsorption/desorption, free fatty acid, a major component of the feed, should be removed by esterification using cation-exchange resin at 50 degree C.
実用化イメージ

This innovative technology succeeds in solving the serious problems in the current tocotrienol production, the large weight loss due to the thermal decomposition and large amount of remaining impurities. This technology applies to the production of not only tocotrienol but also tocopherol as bioactive compounds s in food chemicals.

Researchers

Graduate School of Engineering

Naomi Kitakawa

[Advanced Brain Science]

Resarch and development for maintaining and improving brain and mental health

特徴・独自性
  • The Smart Aging International Research Center (SAIRC) was founded on 1 October 2009. This Center proposes the creation of a new field to produce well-rounded personnel who have gained “totally comprehensive intelligence” from their experience, in order to cope with various problems associated with the diverse and complex super-aging society. To this end, the Center will promote interdisciplinary cooperative research, international collaborative research projects, and research collaborations with industry, as well as disseminate and exchange information by holding international conferences and symposia.  The SAIRC is designed to develop an approach for maintaining and improving brain and mental health in a diverse and complex society from the standpoints of brain science, with the aim of maintaining and improving brain functions; cognitive neuroscience and psychology, with the aim of maintaining a healthy and tranquil state of mind at each aging stage; and philosophy, phenomenology and ethics that provide a radical reconsideration of the concept of the “mind.” We welcome collaborative researches with companies, and academic consultations.
実用化イメージ

Researchers

Institute of Development, Aging and Cancer

Ryuta Kawashima

[Advanced Functional Electronic Devices]

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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特徴・独自性
  • Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.
実用化イメージ

Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Researchers

Graduate School of Medicine

Kei Takase

[Aeroelasticity]

Nonlinear Aeroelastic and Multibody Dynamic Analysis for Floating Wind Turbine and Next-Generation Aircraft

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概要

Floating wind turbine and next-generation aircraft have high-aspect-ratio blade and wing that undergo nonlinear aeroelastic deformation. We have developed a nonlinear aeroelastic analysis framework with absolute nodal coordinate formulation (ANCF). This nonlinear aeroelastic deformation is coupled with multibody dynamics. We are also developing a novel analysis framework for this coupling dynamics.

従来技術との比較

By using the nonlinear analysis method proposed in this study, it is possible to handle the reduction in flutter speed due to large deformations and the coupled phenomenon of deformation and flight behavior that cannot be captured using conventional linear analysis methods.

特徴・独自性
  • Straightforward nonlinear structural analysis method that does not use any rotational coordinates
  • Highly efficient unsteady fluid calculation method for large deformations
  • Multibody dynamics that captures the relative motion between bodies, such as rotating blades and control surfaces
実用化イメージ

Dynamic, aeroelastic, structural, vibration, aerodynamic analyses for Aeroelastic Multibody Systems:
1. Floating wind turbine
2. High altitude platform station (HAPS), high-aspect-ratio-wing commercial jet
3. Helicopter, drone
4. Robot, crane

Researchers

Graduate School of Engineering

Keisuke Otsuka

[aging]

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

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特徴・独自性
  • "Features"
  • High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
  • "Targeted Application(s)/Industry"
  • High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.
実用化イメージ

Researchers

Graduate School of Biomedical Engineering

Yoshifumi Saijo

Brain Development and Aging Using Large Brain MRI Database

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特徴・独自性
  • We have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database.
実用化イメージ

Our research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up.

Researchers

Smart-Aging Research Center

Yasuyuki Taki

Economics of Aging

特徴・独自性
  • I investigate on the economics of aging, the optimal social welfare policy, low fertility and so on not based on the historical and systematic approach but based on the neo-classical economic theory. I also use econometric method and statistical approach. I often estimate the future projections of the population, public finance, magnitude of private markets, the results of public policies.
  • I also research on the comparative studies on East Asia (Japan, China, Korea, Taiwan) and European (especially Scandinavian countries). I provide statistic data and information on the economic and political systems on the aging in Japan.
実用化イメージ

The future estimation on the financial status , market caused by low fertility and aging. The effective management of the medical institutions, social welfare systems, gender equality societies for the central and local government, research institutions, public enterprises, and financial Institutions.

Researchers

Graduate School of Economics and Management

Hiroshi Yoshida

[aging care]

The Novel Ultrasound Irradiation Device

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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[AI]

Skeletal Regulation of Energy Metabolism

特徴・独自性
  • This project studies the influence of bone on energy metabolism in the body through health and disease.
実用化イメージ

This project may come up with new tools for metabolic syndrome prediction, therapy and diagnosis .

Researchers

Frontier Research Institute for Interdisciplinary Sciences

Aseel Mahmoud Suleiman Marahleh