- 特徴・独自性
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- "Features"
- High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
- "Targeted Application(s)/Industry"
- High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.
- 実用化イメージ
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Researchers
Graduate School of Biomedical Engineering
Yoshifumi Saijo
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- 特徴・独自性
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- A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
- 実用化イメージ
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Researchers
Graduate School of Engineering
Hironori Tohmyoh
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- 特徴・独自性
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- Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
- 実用化イメージ
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Our aims are to export the device internationally. We seek the investment and international business partners.
Researchers
Research Center for Accelerator and Radioisotope Science
Katsunori Nonogaki
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- 概要
Ultrasonic measurement is an important technique that is used in various fields of science and technology, including physical property evaluation, imaging and sensing. I use a measurement technique that uses light to excite and detect ultrasonic waves in the frequency range of GHz to THz, and I use this to evaluate the mechanical and acoustic properties of microstructures and thin films with sizes in the nano to micro range, as well as for non-destructive testing.
- 従来技術との比較
Conventional ultrasound had a wavelength of several micrometres or more, so it was impossible to measure at the nanoscale. However, by using femtosecond pulse lasers to manipulate ultrasound with a wavelength of the order of 10 nm, I have achieved the evaluation of the mechanical properties of nano-materials and non-destructive testing in the nano-region.
- 特徴・独自性
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- Development of unique measurement technology that makes full use of light and sound (lasers and ultrasound)
- Excitation and detection of vibration phenomena in nano-materials and GHz bands
- Accurate measurement of sound velocity and elastic constants under high magnetic fields of 10 to 600 K and up to 5 T
- Measurement of magnetic damping constants and saturation magnetisation from magnetisation oscillations in the time domain
- Main targets include nano-thin films of metals, piezoelectric materials, and magnetic materials, as well as superhard materials such as diamond and tungsten carbide
- Contributing to the development of materials and the elucidation of the characteristics of filters for wireless communication in smartphones
- Applications include the development of highly sensitive biosensors using ultrasound, which has a shorter wavelength than light, and monitoring the breaking process of nanowires
- 実用化イメージ
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This measurement method enables the inspection of defects in semiconductors on the order of nm, and the evaluation of the characteristics of acoustic filters, which are essential for 5G communication devices.
Researchers
Graduate School of Engineering
Akira Nagakubo
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- 特徴・独自性
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- Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured by CT, MRI, SPECT, or conventional ultrasound. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions (US patent 5840028), we have detected the minute mechanical response (velocity component) to the propagation of the action potential in the human heart or to detect the propagation of the vibrations along the heart wall caused by the valve closure (Fig. 2).
- By applying the same procedure to the human arteries, the regional change in wall thickness caused during one cardiac cycle can be measured with high spatial resolution (Fig. 1). From the measurement, the regional elasticity of tissue surrounding atherosclerotic plaque can be determined. By comparing the pathological findings with the distribution of elasticity, elasticity of lipid and that of fibrous tissue were determined. Thus, each point inside the plaque is classified into lipid or fibrous tissue using transcutaneous ultrasound (Fig. 3).
- 実用化イメージ
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This novel method offers potential as a diagnostic technique for detection of plaque vulnerability with high spatial resolution. We are prepared to provide academic consultations to companies interested in our research.
Researchers
Graduate School of Engineering
Hiroshi Kanai
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- 概要
My current research topic is "universal design in language use," with special reference to order in language and thought. In particular, I am investigating (1) similarities and differences in neural processing of languages with different basic word orders, (2) to what extent the order in non-verbal thought is affected by the order in language, and vice versa, and (3) what is the optimal order in human language and human thought, if any.
- 従来技術との比較
Many studies have reported that subject-object (SO) word order, where the subject (S) precedes the object (O), tends to have lower processing costs and is preferred by native speakers compared to object-subject (OS) word order. However, traditional studies have primarily focused on SO languages, such as Japanese and English, where SO word order is the grammatical default. As a result, it remains unclear whether the preference for SO word order reflects the basic word order of individual languages or more universal cognitive characteristics of humans.
- 特徴・独自性
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- To address this, we are conducting research on the cognitive processing of minority languages that use object-subject (OS) word order as their basic word order—specifically Kaqchikel and Truku, which have not been studied before. This research focuses on the relationship between “word order in language” and “order of thought.” The findings are then compared to the cognitive processing of Japanese and English.
- For this purpose, experimental equipment is brought to the speakers’ regions (Guatemala and Taiwan) to conduct a variety of investigations and experiments, including behavioral experiments, eye-tracking, and brain function measurements. Additionally, for experiments requiring large, non-portable equipment such as MRI scanners, the speakers are invited to Japan for the studies.
- 実用化イメージ
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Although I am conducting basic research, I believe it helps develop (1) effective language teaching/learning methods, (2) rehabilitation programs for aphasia, (3) dynamic preservation of endangered languages/dialects, and so on.
Researchers
Graduate School of Arts and Letters
Masatoshi Koizumi
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