Tohoku University. Research Profiles

LANGUAGE

"U" Keywords - 14 Result(s)

U

 U

[Ubiquitylation]

Elucidation of oncogenesis by Fbxw7

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In life science research field, it is noteworthy issue how information in genome is interpreted and is transferred to functional molecules. However, during these 10 years, we convinced that the amount of proteins, final functional molecules was regulated by not only by production but also by degradation. For examples, the amount of c-Myc, which promotes cell cycle and inhibits cell death, increase in many types of cancer by failure of protein degradation.
We have generated model mice in which function of Fbxw7, inducer of c-Myc degradation is suppressed. We observed promotion of oncogenesis in these mice, suggesting that Fbxw7 is oncosuppressor gene. In other words, Fbxw7 has a great potential to regulate oncogenesis or progress of cancer. These molecules specified the target proteins for proteolysis suggesting that modification of these molecules leads to develop oncosuppressive therapy. We hope to conduct collaborative research with a willing company for a practical application of this knowledge in industry.

Targeted Application(s)/Industry

Graduate School of Medicine
NAKAYAMA Keiko, Professor Medical Doctor

[Ultrasonic wave]

The Novel Ultrasound Irradiation Device

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Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.

Targeted Application(s)/Industry

Our aims are to export the device internationally. We seek the investment and international business partners.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI Katsunori, Professor MD, PhD

[Ultrathin metallic wire]

Joule Heat Welding of Ultrathin Metallic Wires and its Application for Producing Functionality

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For producing a new functionality from metallic micro and nano matarials, the welding and cutting technologies for small scale materials utilizing Joule heat has been developed (Fig. 1). A constant direct current is supplied to the system, where the free ends of two metallic wires are contacted, and the ends are successfully welded together in self-completed manner. This technology is also useful for manipulating a small scale materials.

Targeted Application(s)/Industry

Joule heat welding technology enables us to produce the functional elements on the electrode chips, e.g., a free-standing micro-ring and very-thin thermoelectric element (Fig. 2). Moreover, we have developed the technique for characterizing the physical properties of small scale materials (Fig. 3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
TOHMYOH Hironori, Professor Doctor of Engineering

[Unused low temperature heat]

Low temperature reforming of hydrocarbons using metal oxide nanoparticles synthesized by supercritical method

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Our research group has succeeded in synthesizing various metal oxide nanoparticles with controlled size and exposure crystal planes by using organic modifiers under supercritical water conditions. The oxygen storage/release capacity of those materials in the low-temperature region is very high, and the reforming reaction of oxidative hydrocarbon proceeds at a significant rate. Besides, by combining the supercritical CO2 drying method, we have succeeded in forming a complex in which oxide nanoparticles are dispersed at a high concentration on the surface of the porous material, realizing both high oxygen storage/release capability and stability.

Targeted Application(s)/Industry

Low-temperature reforming reaction of biomass wastes, heavy oils, and methane. In the future, it is expected to be a technology that will lead to the construction of a low-carbon society, including CO2-free complete recycling of waste plastics.

Advanced Institute for Materials Research
ADSCHIRI Tadafumi, Professor Doctor of Engineering

[Urban Mining]

A Study on the Proper Waste Management and Urban Mining Project in Asian Countries; International Resources Recycling and Cross-Border Pollution

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The objective of this research is to maximize international resource recycling efficiency through a feasibility assessment of urban mining project in East Asia. It is not only focused on valuable materials but also on less valuable materials like waste plastics. The merit of this approach is its consideration of social, economic and environmental systems in each country.

Targeted Application(s)/Industry

This research is envisioned to support the establishment of resource recycling systems, developing new business models, people-to-people exchange and information sharing.

Graduate School of International Cultural Studies
YU Jeongsoo, Professor PhD(Urban and Regional Planning)

[User Interface]

Interactive Content to Enrich Our Lives

Features

(1) Displays and Interactive Techniques
Designing original display systems to show visual information accurately and effectively, and interaction techniques to make better use of these display systems.

(2) Interactive Video Content
Creating new interactive content from real video taken by cameras and computer-generated animations.

(3) Modeling and Controlling the “Atmosphere” in a Conversation Space
Aiming to stimulate the “atmosphere” in a conversation space by supplying real-time feedback to the users, we are exploring means of sensing and analyzing change in the space.

(4) Designing and Evaluating Novel Interaction Techniques
Designing and evaluating novel interaction techniques on target selection for variety types of displays including large and touch displays.

Targeted Application(s)/Industry

Research Institute of Electrical Communication
KITAMURA Yoshifumi, Professor Doctor of Engineering

 u

[ultra-low radioactivity environment]

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.

Targeted Application(s)/Industry

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Research Center for Neutrino Science
INOUE Kunio, Professor Doctor of Science

[ultra-realistic communication]

Development of the high-quality and low-power display system for ultra-realistic communications

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Recently, with a spread of high definition video streaming services and ubiquitous network, development of high-quality, ultra-realistic and low-power display systems has been demanded. We have been studying physical properties of liquid crystal materials, precise control technique of polarization, high performance liquid crystal display (LCD) devices and its application to the advanced display systems for the realization of new media such as electric paper display and digital signage display, and low-energy society. We established a polarization control technology which realizes a precise control of polarization with liquid crystal materials. By using this world-leading technology, we have been studying the control of the surface alignment of liquid crystal molecules and developed a wide-viewing angle and fast switching liquid crystal display, ultra-high definition field-sequential-color display (Fig. 1), ultra-low power reflective full-color display (Fig. 2) and large-size high-quality display system.
We are also studying the ultra-realistic display systems such as a spatial 3D display and a multiple directional viewing display based on the precise light control technique as a next generation interactive communication technologies (Fig.3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
ISHINABE Takahiro, Associate Professor Doctor of Engineering

[ultrasound]

Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries

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Features

Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured by CT, MRI, SPECT, or conventional ultrasound. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions (US patent 5840028), we have detected the minute mechanical response (velocity component) to the propagation of the action potential in the human heart or to detect the propagation of the vibrations along the heart wall caused by the valve closure (Fig. 2).
By applying the same procedure to the human arteries, the regional change in wall thickness caused during one cardiac cycle can be measured with high spatial resolution (Fig. 1). From the measurement, the regional elasticity of tissue surrounding atherosclerotic plaque can be determined. By comparing the pathological findings with the distribution of elasticity, elasticity of lipid and that of fibrous tissue were determined. Thus, each point inside the plaque is classified into lipid or fibrous tissue using transcutaneous ultrasound (Fig. 3).

Targeted Application(s)/Industry

This novel method offers potential as a diagnostic technique for detection of plaque vulnerability with high spatial resolution.
We are prepared to provide academic consultations to companies interested in our research.

Department of Electronic Engineering, Graduate School of Engineering
KANAI Hiroshi, Professor PhD

The Novel Ultrasound Irradiation Device

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Features

Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.

Targeted Application(s)/Industry

Our aims are to export the device internationally. We seek the investment and international business partners.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI Katsunori, Professor MD, PhD

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

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Features

"Features"
High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
"Targeted Application(s)/Industry"
High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.

Targeted Application(s)/Industry

Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering
SAIJO Yoshifumi, Professor PhD (Medicine)

Dry-Contact Ultrasonic Technique

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A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
TOHMYOH Hironori, Professor Doctor of Engineering

[ultrasound microscope]

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

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Features

"Features"
High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
"Targeted Application(s)/Industry"
High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.

Targeted Application(s)/Industry

Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering
SAIJO Yoshifumi, Professor PhD (Medicine)

[use of waste acid oil]

A Novel Process for Continuous Production of High Quality Biodiesel with Ion-Exchange Resin Catalysts

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We successfully developed a continuous production process for high-quality biodiesel. This production technology is very simple, just passing through the reactors packed with ion-exchange resins without complicated upstream and downstream processes, which provide additional production cost and environmental stress and the entire process is fully automatic. With this technology, you can easily produce high-quality biodiesel from various cheaper oils with fatty acid content up to 100%.

Targeted Application(s)/Industry

This innovative technology succeeds in solving the serious problems in the current biodiesel production, restriction by shortage of feedstock supply and the unstable quality of biodiesel due to the soap formation. This technology also applies to the production of fatty acid methyl ester, a starting material for surfactant production, which is an important intermediate step in oleochemistry.

Graduate School of Engineering
SHIBASAKI-KITAKAWA Naomi, Professor Doctor of Engineering