Tohoku University. Research Profiles

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"T" Keywords - 59 Result(s)

T

 T

[Tactile sensor]

Study on Tactile/Touch Feeling Sensor

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Features

Tactile sense and the sense of touch are multiple combinations of fundamental sensations, such as smooth and rough, soft and hard, dry and wet, and hot and cold sensations. These sensations are described with the information on force, distortion, temperature, stickiness and oscillation.
A tactile sensor corresponding to several types of human skin sensory receptors and an active tactile sensor system that is an integrated sensor structure imitating human haptic motions have been developed. These sensor systems allowed measurement of "Kansei" words that are extremely vague tactile feelings, and roughness, softness and temperature sensations. However, tactile sense or the sense of touch also includes other sensations and combinations of them. Therefore, to develop a sensor, it is important to define how the sensations and physical information relating to the sensations are obtained and what relationships exist between them.
In this research, the relationships between sensations, including fundamental sensations that have already been obtained and other sensations, and the relevant physical information are being investigated. Additionally, on the basis of the knowledge through the investigation, an advanced sensor system that allows obtaining haptic information is being developed.

Targeted Application(s)/Industry

The research is beneficial not only to life science but also to manufacturing fields.

Graduate School of Biomedical Engineering
TANAKA Mami, Professor PhD (Engineering)

[Targeted Absolute Proteomics]

Highly Sensitive and Simultaneous Absolute Protein Quantification by LC-MS/MS

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Quantification of functional proteins in each organ of animals and humans at normal and disease states is fundamental for drug discovery and development. The target proteins were digested in-silico, and target peptides for analysis were chosen on the basis of the selection criteria. Samples tissues were digested with trypsin, and mixed with stable isotope labeled-peptide as a quantitative standard. The amounts of target proteins were simultaneously determined by the HPLC system connected to an ESI–triple quadrupole mass spectrometer. A detection limit would be ~ 1 fmol/assay and 37 different proteins could be quantified simultaneously.

Targeted Application(s)/Industry

This technology will be applicable for the drug discovery and development, diagnosis, personalized chemotherapy. This technology will be widely applicable for any life science relating industries including food and environment science. Fig. 3 summarizes possible applications for Pharmaceutical and Medical fields.

Graduate School of Pharmaceutical Sciences
TERASAKI Tetsuya, Professor PhD,

[Targeted endogenous molecules]

Drug Development for Fundamental Treatment of Alzheimer's Disease

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Background: Alzheimer's disease (AD) is a neurodegenerative disorder with a large unmet medical need. Recently, our pilot clinical study suggested the possibility that 1-year oral administration of decocted nobiletin-rich Citrus reticulata peel could be of benefit for improving the cognition of patients with AD, with the following pharmacological features: 1) this Kampo medicine includes a large amount of nobiletin that can rescue the memory impairment and prevents hippocampal amyloid beta accumulation in APP-Tg mice, as originally reported by us, and 2) the medicine reversed impaired learning and memory to a greater degree than nobiletin in animal, to which sinensetin, another constituent contributes in large part.
Research plan: We thus try to identify endogenous molecules that can bind selectively to nobiletin and sinensetin in hippocampal neurons, and to further synthesize novel compounds that are capable of more potently improving learning and memory impairment in animals than both natural compounds.

Targeted Application(s)/Industry

Our research goal is discovery of the drugs for fundamental treatment of AD. I hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences
YAMAKUNI Tohru, PhD

[Tau imaging]

Biomarker Development and Preemptive Therapy of Alzheimer's Disease

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Over the past 20 years, our understanding of molecular pathology of dementia and AD has dramatically deepened, and new biomarkers including amyloid PET and cerebrospinal fluid (CSF) amyloid42/tau as well as therapeutic strategies have been developed. However, clinical trials of disease-modifying drugs in mild to moderate AD were unsuccessful or were halted due to serious adverse drug effects.

Targeted Application(s)/Industry

These results strongly suggest that disease-modifying therapies should be started much earlier before a widespread neuron death will occur. We hope that early detection and prevention with preemptive therapy may lead to a success of fighting AD.

Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer
ARAI Hiroyuki, Professor MD, PhD

[Terahertz]

Development of Frequency Tunable Coherent TERAHERTZ Light Sources and their Potential Applications

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Terahertz wave (THz) is quite new electromagnetic wave. THz wave is expected to show wide variety of important practical applications. In view of the scientific fields, THz spectroscopy can reveal quite new inter-molecular vibration. We successfully realized the THz wave emission via both non-linear optical effects of NIR laser light and the high frequency semiconductor device operations. The frequency region realized is ranging between 0.03THz and a few 10 THz. It is also noted that the device assembly of THz semiconductor devices and the crystal growth of non-linear optical crystal have been performed in our laboratory.

Targeted Application(s)/Industry

Applications
Non-destructive and non-contact defect recognition of building blocks and water diffusion recognition in polymers, paints, woods and concrete, adhesion failure of ceramics tiles on concrete walls, chirality discrimination of medicines, hydro-oxide formation of medicines, recognition of polytypes of organic and nonorganic crystalline compounds, THz spectroscopic imaging using specific molecular vibrations

Industry
Civil and architecture engineering, Metal construction like bridge, tunnel construction, automobile and train, semiconductor fabrication, electronic device fabrication, medicine, chemical engineering.

Department of Materials Science and Engineering, Graduate School of Engineering
OYAMA Yutaka, Professor Doctor of Engineering

Spintronics Devices and Materials

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Spintronics is a technology utilizing electron spin which provided magnetic sensor, nonvolatile magnetic memory, and so on. Our studies are as below.

Noble & Rare-earth free magnetic films with large perpendicular magnetic anisotropy. We achieved to develop various Mn-bases alloy films exhibiting high perpendicular magnetic anisotropy (Fig.1 ).
THz range observation of magnetization motion. We achieved to detect a motion of magnetization using pulse laser in time domain (Fig. 2).
Novel organic spin devices. We achieved to fabricate hybrid junction consisting of an organic layer sandwiched by two inorganic magnetic layers and to observe magnetoresistance effect.
Tunnel Magnetoresistive devices: We are developing TMR devices with Mn-Ga alloys films (Fig.3 ).

Targeted Application(s)/Industry

Magnetic memory and storage. Microwave and Terahertz wave. Magnetic sensors.
We hope to conduct collaborative research with a willing company for a practical application of these devices and materials in industry.

WPI Advanced Institute for Materials Research
MIZUKAMI Shigemi, Professor Doctor of Engineering

[Thallium Bromide (TlBr)]

Development of Compound Semiconductor Radiation Detectors

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The main research subject of our group is developing material purification methods, crystal growth methods and detector fabrication technologies for compound semiconductor radiation detectors. Our group intensely studies a compound semiconductor, thallium bromide (TlBr), for fabrication of gamma-ray detectors for the advanced radiation applications. The attractive physical properties of TlBr lie in its high atomic number (Tl: 81, Br: 35), high density (7.56 g/cm3) and wide bandgap (2.68 eV). Due to the high atomic number and high density, TlBr exhibits high photon stopping power. The wide bandgap of TlBr permits the device low-noise operation at and above room temperatures.

Targeted Application(s)/Industry

Our group focuses on development of compound semiconductor radiation detectors for advanced radiation applications including ultra-high resolution PET systems, ultra-high resolution SPECT systems, photon counting CT systems and Compton cameras. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Department of Quantum Science and Energy Engineering, Graduate School of Engineering
HITOMI Keitaro, Associate Professor Doctor of Engineering

[The 2011 Tohoku earthquake]

[The Mirror Magical]

Project “The Mirror Magical”: Remote and Non-Contact Extraction of Biological Information

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We engage in development of a cyber-medical system, “The Mirror Magical” for taking a medical check-up anytime and anywhere by use of information and communication technology (ICT). We only have to stand still in front of the mirror to check our autonomic nervous function related to baroreflex on the basis of video signals capable of remote and non-contact measurement. Demonstration experiments have been held to verify the validity of the system in estimation of blood pressure variability and the effects of physical exercise.

Targeted Application(s)/Industry

We can conduct effective collaborative research using the system not only in medical and welfare fields but also for application to smartphones, automobiles, emotion recognition robots, security cameras, sports broadcast and so on.

Center for Promotion of Innovation Strategy
YOSHIZAWA Makoto, Dr Eng

[Therapeutic apparatus]

Biometric Monitor and Therapeutic Apparatus System Mounted Inside Mouth

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We propose the biometric monitor and therapeutic apparatus system with telemedicine, especially for the elderly and patients with chronic diseases. This system is consisted of the sensor probes gathering biometric information and daily living activities, the signal processing units with wireless telecommunication with telemedicine center, and the therapeutic operation units with drug delivery into the mouth.

Targeted Application(s)/Industry

This system is embedded in usual dental prosthesis, such as denture or mouthpiece, so that this system can be installed into the mouth with no sense of discomfort. The system provides the necessary means of health support in an aging society, especially for the elderly who live alone and the hospital inpatients.

Graduate School of Dentistry
KOSEKI Takeyoshi, Professor PhD

[Thermodynamics]

Eco-Material Processing

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The major subject of our group is ferrous process metallurgy including thermodynamics of metals, alloys and molten slags, high temperature heterogeneous kinetics, phase equilibria of complex oxide systems and so on. We are interested in physic-chemical fundamentals of processing of metals, slags, scrap and waste. Recently our research interests are extended to multidisciplinary area so-called "Industrial Ecology" by the combination of process metallurgy, LCA (life cycle assessment) and social science such as econometrics.

Targeted Application(s)/Industry

Typically our research group is aggressively working in the area of material flow analysis of critical metals considering the quality of recycled materials. Currently our major research partners are steel and non-ferrous industries, while we do hope to collaborate with waste treatment company, mineral industry and an administrative organ.

Department of Metallurgy, Graduate School of Engineering
NAGASAKA Tetsuya, Professor Doctor of Engieering

[Thin-film type sensor]

Chemical imaging devices which operate in severe environments

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We developed both pH and Cl- imaging plates, which can visualize the pH and Cl- concentration on metal surfaces in acidic environments. The pH range is from 3.0 to 0.5, and Cl- concentration up to 4 M can be measured. Fluorescent dyes are successively used for pH and Cl- imaging in the field of biology, but their sensitivity tends to be insufficient in acidic and/or highly concentrated chloride solutions. A glass plate with a sol-gel sensing layer, which contains a pH indicator or a Cl- sensitive florescent dye was fabricated and validated using the solutions with various pH values and Cl- concentrations. Changes in the pH and Cl- distribution on stainless surface in an acidic environment were measured quantitatively.

Targeted Application(s)/Industry

The newly developed imaging plates can be used to investigate the mechanism of various chemical reactions, such as corrosion, which occurs in an acidic environment. Micro-flow imaging using our sensing technique will be a promising approach to understand the catalytic chemistry of metal surfaces.
強調

Department of Materials Science, Graduate School of Engineering
MUTO Izumi, Professor Doctor of Engineering

 t

[testosterone]

Prevention and amelioration of late-onset hypogonadism by food ingredients

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Late-onset hypogonadism (LOH) is induced by age-related decline of testosterone synthesis, which leads to decrease muscle and sexual nature as well as mental symptoms such as depression. Now great attention is focused on prevention and amelioration of LOH via ingestion of foods and supplements.

We developed screening system of functional ingredients from food extracts for anti-LOH using testis-derived cells, and clarified that vitamins, nutraceuticals, and edible plant extracts have potentiating activities for the production of testosterone.

Targeted Application(s)/Industry

Graduate School of Agricultural Science
SHIRAKAWA Hitoshi, Professor Doctor of Agricultural Science

[thermal radiation]

Development of Renewable Energy Systems for Sustainable Development Society

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Development of renewable energy systems as well as research on high efficient energy conversion systems is a key technology to solve the global-scale environmental destruction and energy problems. We are working on the research on the advanced technology of renewable energy such as solar energy and hydrogen. Topics of research are two of the following roughly separately. 
(1) Development of highly effective thermal energy systems and energy saving systems by using spectral control of thermal radiation. 
(2) Aiming at the achievement of the hydrogen energy society, we develop new energy conversion devices based on solid state ionics, and perform feasible studies for solid oxide fuel cells (SOFCs) based on mechanics of materials.

Targeted Application(s)/Industry

High temperature solar absorption materials
High effieciency solar-termophotovoltaic (STPV) system
Small power source for mobile electric devices based on micro-SOFC
New energy harvesting devices in harsh environment

Department of Mechanical Systems and Design, Graduate School of Engineering
YUGAMI Hiroo, Professor Doctor of Engineering

[thermoacoustics]

Understanding and application of thermoacoustic phenomena

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Acoustic oscillations of a gas column in narrow flow channels can lead to various thermal phenomena such as production and amplification of acoustic power from heat and generation of low temperatures. We aim at understanding these thermoacoustic phenomena from experimental point of view, and developing heat engines that can operate without any moving parts like solid pistons.

Targeted Application(s)/Industry

Acoustic prime mover can use various heat sources like industrial waste heat and sunlight. Acoustic cooler is a Helium-gas based heat pump that needs no Freon gases as a coolant.

Graduate School of Engineering
BIWA Tetsushi, Professor Doctor of Engineering

[thermoelectric conversion]

Hierarchy Control in Structure and Creation of Novel Properties in Nano Scale Materials

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Crystals produced from the building blocks using a concept of geometrical materials, from the ubiquitous elements such as B, C, N, O, Si, Ge and 3-d elements show the following characteristics:
(1) Special properties resulting from the bonding nature and geometrical symmery.
(2) New properties expected from confinement and interface.
(3) A variety of phonons as phonon engineering.
(4) Interplay among phonons, itinerant electrons and magnons.
Materials are synthesized using the strategy of natural aboundant ubiquitous elements for safety. Novel properties can be expected for advanced electronic devices. The structure of new materials can accurately be determined by various experimental techniques.

Targeted Application(s)/Industry

New materials produced by employing a new concept beyond the conventional methods can promote a new materials science for future electronics. Our research covers nano materials consisting of organic to innorganic elements. Thermoelectric materials for energy conversion and high mobility materials via Dirac quantum statse will be avialable for future electronic materials.

WPI Advanced Institute for Materials Research
TANIGAKI Katsumi, Professor Doctor of Engineering

[thermophotocoltaic]

Development of Renewable Energy Systems for Sustainable Development Society

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Development of renewable energy systems as well as research on high efficient energy conversion systems is a key technology to solve the global-scale environmental destruction and energy problems. We are working on the research on the advanced technology of renewable energy such as solar energy and hydrogen. Topics of research are two of the following roughly separately. 
(1) Development of highly effective thermal energy systems and energy saving systems by using spectral control of thermal radiation. 
(2) Aiming at the achievement of the hydrogen energy society, we develop new energy conversion devices based on solid state ionics, and perform feasible studies for solid oxide fuel cells (SOFCs) based on mechanics of materials.

Targeted Application(s)/Industry

High temperature solar absorption materials
High effieciency solar-termophotovoltaic (STPV) system
Small power source for mobile electric devices based on micro-SOFC
New energy harvesting devices in harsh environment

Department of Mechanical Systems and Design, Graduate School of Engineering
YUGAMI Hiroo, Professor Doctor of Engineering

[thermophysical properties of high-temperature melts]

High-Temperature Processes and Measurements of Materials

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Fukuyama laboratory studies novel material processing based on chemical thermodynamics with high-temperature thermophysical property measurements. As examples, we are developing new crystal growth processes to bring a breakthrough in nitride-semiconductor devices, which are promising materials for next-generation optical devices applied in environmental, medical, bio and information technologies fields. Database of thermophysical properties of materials is needed for modeling heat and mass transports in materials processes.

Targeted Application(s)/Industry

A new thermophysical property measurement system is currently under development, which enables accurate measurements of heat capacity, thermal conductivity, emissivity, density and surface tension of high-temperature melts, utilizing electromagnetic levitation in a dc magnetic field.

Institute of Multidisciplinary Research for Advanced Materials
FUKUYAMA Hiroyuki, Professor Doctor of Engineering

[thermos/thermomechanical properties]

Multi-functionalization of composite materials by microstructure design

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For further social development, it is required the miniaturization, weight saving, high performance of various devices. We study on fiber, particle reinforced polymer, metal, ceramic matrices composite materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop multi-functionalized composite materials, which have high strength, super lightweight, energy harvesting function, damage monitoring function, biodegradable at the same time.

Targeted Application(s)/Industry

Department of Materials Processing, Graduate School of Engineering
KURITA Hiroki, Assistant Professor Doctor of Engineering

[thin film]

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

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"Features"
High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
"Targeted Application(s)/Industry"
High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.

Targeted Application(s)/Industry

Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering
SAIJO Yoshifumi, Professor PhD (Medicine)