"D" Keywords - 75 Result(s)
D
[Dental prosthesis]
High-Precision Capturing of 3-D Dental-Arch Shapes and Their Occlusal Relation and its Potential Implementation into CAD/CAM DentistryFeaturesIn spite of the long history of digital dentistry, the accuracy of the prosthetics fabricated with CAD/CAM systems is far from satisfactory. Jaw opening during taking impression elicits deformation of the mandible and the lower dental arch, and consequently causes the inaccuracy of occlusal relationship of the upper and lower dental arches on the CAD data. The method presented here utilizes the check-bite record at the maximum intercuspation to correct the relative positions among the teeth in the dental arches as well as between the arches. After this correction, the accuracy of the CAD data is satisfactory enough for the fabrication of the dental prosthetics which need no adjustment during their setting. Targeted Application(s)/IndustryThis method uses the newly-developed check-bite recording technique together with the conventional precious impression or optical impression techniques. It can easily be applied to the commercial CAD/CAM systems in the market. We hope to collaborate to the manufacturers of dental CAD/CAM systems to increase the accuracy of the systems. |
[Deposition]
Molecular Dynamics Analysis of Coating and Surface ModificationFeaturesMolecular-scale mechanism of solid-liquid affinity, wettability, thermal boundary resistance and molecular deposition are analyzed by molecular dynamics simulations toward its control. With a background of heat and mass transport and interfacial thermodynamics, transport phenomena of various scales ranging from spin coating of photoresist to SAM (self-assembled monolayer) and hydrophobic/hydrophilic treatment by attaching some molecular basis are studied. Futhermore, the molecular-scale mechanisms which determine thermophysical properties and the molecular structure that realizes desired thermophysical properties are studied. We can conduct effective collaboration and provide academic consultations to companies interested in our research. |
[Design and Evaluation of Properties of Materials]
Prediction and Prevention of FracturesFeaturesWe have been developing methods for explicating the dominant factors that determine the physical and chemical properties of materials and stacked structures used in human societies. Since the number of element atoms which consists of advanced materials has been increasing, and the crystallographic structure of the materials has become very complicated, both the various properties and reliability of the materials fluctuate significantly in nano-scale, and thus, deteriorate easily due to the local damages of the materials. Targeted Application(s)/IndustryTo design the optimal structure, composition of materials, and the fabrication process of both materials and stacked structures, we are going to develop a method of analyzing the atomic structure of thin film materials based on quantum mechanics and experimental methods for measuring material properties, atomic scale damage or defects in nano-materials. Fracture and Reliability Research Institute, Graduate School of Engineering
MIURA Hideo, Professor
PhD., Dr. of Engineering
|
[Development]
Brain Development and Aging Using Large Brain MRI DatabaseFeaturesWe have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database. Targeted Application(s)/IndustryOur research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up. |
[Developmental Cognitive Neuroscience]
Resarch and development for maintaining and improving brain and mental healthFeaturesThe Smart Aging International Research Center (SAIRC) was founded on 1 October 2009. This Center proposes the creation of a new field to produce well-rounded personnel who have gained “totally comprehensive intelligence” from their experience, in order to cope with various problems associated with the diverse and complex super-aging society. To this end, the Center will promote interdisciplinary cooperative research, international collaborative research projects, and research collaborations with industry, as well as disseminate and exchange information by holding international conferences and symposia. The SAIRC is designed to develop an approach for maintaining and improving brain and mental health in a diverse and complex society from the standpoints of brain science, with the aim of maintaining and improving brain functions; cognitive neuroscience and psychology, with the aim of maintaining a healthy and tranquil state of mind at each aging stage; and philosophy, phenomenology and ethics that provide a radical reconsideration of the concept of the “mind.” We welcome collaborative researches with companies, and academic consultations. Institute of Development, Aging and Cancer
KAWASHIMA Ryuta, Professor
Doctor of Medicine
|
[Device]
The Novel Ultrasound Irradiation DeviceFeaturesDr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care. Targeted Application(s)/IndustryOur aims are to export the device internationally. We seek the investment and international business partners. Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI Katsunori, Professor
MD, PhD
|
Drug Delivery System for Retinal ProtectionFeaturesIntravitreal injection of some drugs to treat retinal diseases has been successfully reported. However, there is a possibility of severe side effects, such as infection. So we have developed a transscleral drug delivery system by using non-biodegradable device, which enabled sustained drug delivery to the retina. Because of the nature of the device, we can deliver the multi-drug independently. We have performed our work in collaboration with Department of Bioengineering and Robotics. Targeted Application(s)/IndustryUsing this drug delivery device, we may be able to apply our system not only to the retinal diseases but also to other diseases. Division of Clinical Cell Therapy, Graduate School of Medicine
ABE Toshiaki, Professor
MD
|
[devices]
Room temperature bonding using thin metal films (Atomic Diffusion Bonding)FeaturesAtomic diffusion bonding of two flat wafers with thin metal films is a promising process to achieve wafer bonding at room temperature. High surface energies of metal films and a large atomic diffusion coefficient at the grain boundaries and film surfaces enable bonding at room temperature without unusually high loading pressure. This technique, which enables bonding of any mirror-polished wafer, is gaining wider use for fabricating optical and electrical devices. Moreover, bonding of mirror polished metals and polymer sheets can be achieved, which further extends the application of this bonding technique. Targeted Application(s)/IndustryOptical, power and electrical devices, MEMS, bonding of polymer sheets, metals, and ceramics for precision mechanical equipments. Frontier Research Institute for Interdisciplinary Sciences
SHIMATSU Takehito, Professor
Doctor of Engineering
|
[Diabetes]
Development of devices regulating inter-organ neural network for diabetes therapyFeaturesDiabetes induces several complications, including retinopathy and nephropathy. In patients with type 1 diabetes as well as those with type 2 diabetes, pancreatic beta cells have reportedly decreased. Therefore, regeneration therapy of pancreatic beta cells may be very effective for major populations of diabetic patients. We discovered a neuronal network, from the liver, which selectively elicits pancreatic beta cell proliferation (Science 2008, Fig.). In a murine model with insulin-deficient diabetes, stimulation of this network improved diabetes. Thus, building devices which regulate the inter-organ neuronal network may lead to “regenerative therapy” for diabetes which regenerates pancreatic beta cells in the pancreas using patients’ own cells and patients’ own systems. We hope to conduct collaborative research with a willing company for a practical application of this technology. Center for Metabolic Diseases, Graduate School of Medicine
KATAGIRI Hideki, Professor
MD, PhD
|
MEDICINE DETERMINATION SUPPORT SYSTEM AND MEDICINE DETERMINATION SUPPORT PROGRAMFeaturesAIMS: This invention is to support the doctor’s prescription for diabetes and metabolic syndrome, especially in Japanese Clinic (Patent: JP 4176438). Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI Katsunori, Professor
MD, PhD
|
The Novel Ultrasound Irradiation DeviceFeaturesDr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care. Targeted Application(s)/IndustryOur aims are to export the device internationally. We seek the investment and international business partners. Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI Katsunori, Professor
MD, PhD
|
Exercising "Cultured" Myotubes!FeaturesWe succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay). Targeted Application(s)/IndustryTaking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen. |
Skeletal Regulation of Energy MetabolismFeaturesThis project studies the influence of bone on energy metabolism in the body through health and disease. Targeted Application(s)/IndustryThis project may come up with new tools for metabolic syndrome prediction, therapy and diagnosis . Frontier Research Institute for Interdisciplinary Sciences Tohoku University
MARAHLEH Aseel, Assistant Professor
DDS PhD
|
[Diagnosis]
Lymph node metastasis prediction and treatment evaluation systemFeatures1. pressure sensor (needle, optical fiber, etc.) can be inserted into the lymph node to evaluate the risk of lymph node metastasis and treatment. Targeted Application(s)/IndustryJoint research with a medical device manufacturer to develop a diagnosis and treatment system for lymph node metastasis Graduate School of Biomedical Engineering
KODAMA Tetsuya, Professor
PhD (Engineering), PhD (Medicine)
|
[Diagnostic marker]
Discovery of diagnostic markers by metabolomicsFeaturesLosing cholesterol homeostasis with inborn errors of metabolisms or hepatobiliary diseases makes a change to in vivo cholesterol metabolism profile and causes the emergence of increased metabolites as conjugates in blood and urine. We have developed an LC/ESI-MS/MS method using fragment patterns characteristic of conjugation types for group-specific and comprehensive analysis of conjugated cholesterol metabolites. This method can contribute for an efficient discovery of diagnostic marker candidates toward various diseases. Targeted Application(s)/IndustryAfter availability verification of candidates as diagnostic markers, it will be required screening tests. We have potential to collaborate with company for development of bioassay systems using antibodies or enzymes. |
[dialogue systems]
Natural Language Processing for Semantic Analysis of Big DataFeaturesThis lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data. Targeted Application(s)/Industry(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc. |
[diarrhetic shellfish poisoning]
Development of a Novel Quantification Method for Diarrhetic Schell Fish PoisoningFeaturesWe have investigated isolation and structure determination of natural products and evaluated mode of their actions. We have especially focused on marine natural products causative for a food poisoning, diarrheic shellfish poisoning (DSP), which has spread worldwide and threatened regional fishery industry. Dinophysistoxin produced by the dinoflagellate Dinophysis spp. and okadaic acid, are thought to be responsible for DSP. Acute toxicity test using mice has been the primary method for detection of DSP in the fish market, though an alternative method to quantify DSP without sacrificing mice has been requested. We isolated OABP2, a novel okadaic acid binding protein, from the marine sponge Halichondria okadai and succeeded in expression of the recombinant OABP2 in E. coli, which eventually showed high affinity to the DSP toxins. Targeted Application(s)/IndustryWe are now working on visualization of OA by utilizing OABP2 in order to provide an easy and quick quantification method for DSP. |
[Die casting]
Advanced die casting process computing with solidification phenomenaFeaturesDie casting is a method of mass-producing high-precision castings in a short time by filling the mold with molten metal at high pressure and high speed. Since solidification is completed quickly under high pressure, various defects peculiar to die casting occur. Significantly, the casting cavity has a high incidence in die casting, and it is a factor that hinders the quality. Therefore, a numerical approach to the die casting process is expected to prevent these problems, and the information obtained from the numerical analysis is expected to be reflected in the casting plan to reduce the number of prototypes, the lead time to product development, and the cost. In this study, a multiphase flow analysis with solidification phenomena of molten aluminum inside mold was conducted for a high-pressure die casting process of the throttle body. Targeted Application(s)/IndustryAutomotive industry, Automotive suppliers, Foundry industry |
[Digital Content]
Interactive Content to Enrich Our LivesFeatures(1) Displays and Interactive Techniques Targeted Application(s)/IndustryResearch Institute of Electrical Communication
KITAMURA Yoshifumi, Professor
Doctor of Engineering
|
[digital learning material]
Applying Blended Learning to Special Needs EducationFeaturesI am interested in the human communication process and the man-machine interaction in some educational situation. I conducted interviews, questionnaires, behavior observations and experiments of students with special educational needs, their parents and teachers to investigate the needs, accessibility, usability, efficacy and its factors of blended learning and digital learning materials. Targeted Application(s)/IndustryThe outcomes of our research will make contribution to the design and development of teaching/learning materials and methods. Graduate School of Educational Informatics Research Division
KUMAI Masayuki, Professor
PhD
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