"D" Keywords - 64 Result(s)

 D

[dimensional metrology]

Development of Sensors and Measuring Systems for Ultra-Precision Manufacturing and Nanomanufacturing

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特徴・独自性
  • The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines, which are important items for ultra-precision manufacturing and nanomanufacturing. Optical sensors are being developed for measurement of angle and displacement, which are fundamental quantities for manufacturing. Technologies for improvement of the sensor sensitivity and bandwidth, reduction of the sensor size as well as new multi-axis sensing methods are being The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines. Optical sensors are being developed for measurement of angle and displacement. A number of scanning-type measuring systems for precision measurement of surface forms and stage motions are also being developed. Error separation algorithms and systems for straightness and roundness, which are the most fundamental geometries treated in ultra-precision manufacturing, are being investigated. Novel systems based on scanning probe microscopy are under development for micro- and nano-structures as well as freeform optics in responding to new and important challenges from ultra-precision manufacturing and nanomanufacturing.
実用化イメージ

The multi-axis optical displacement and angle sensors developed in the laboratory are expected to measure motions of semiconductor/IC manufacturing and inspection equipment, precision machine tools, ultra-precision measuring instrument. The surface profile measurement systems are expected t play an important role in ultra-precision manufacturing and nanomanufacturing industries.

Researchers

Graduate School of Engineering

I Ko

[Dinophysistoxin]

Development of a Novel Quantification Method for Diarrhetic Schell Fish Poisoning

特徴・独自性
  • We have investigated isolation and structure determination of natural products and evaluated mode of their actions. We have especially focused on marine natural products causative for a food poisoning, diarrheic shellfish poisoning (DSP), which has spread worldwide and threatened regional fishery industry. Dinophysistoxin produced by the dinoflagellate Dinophysis spp. and okadaic acid, are thought to be responsible for DSP. Acute toxicity test using mice has been the primary method for detection of DSP in the fish market, though an alternative method to quantify DSP without sacrificing mice has been requested. We isolated OABP2, a novel okadaic acid binding protein, from the marine sponge Halichondria okadai and succeeded in expression of the recombinant OABP2 in E. coli, which eventually showed high affinity to the DSP toxins.
実用化イメージ

We are now working on visualization of OA by utilizing OABP2 in order to provide an easy and quick quantification method for DSP.

Researchers

Graduate School of Agricultural Science

Keiichi Konoki

[Disaster prevention]

[Disaster Response]

Research and Development of Space Exploration Robots

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特徴・独自性
  • We study and develop mobile robotics technology for lunar and planetary exploration. Our technology is featured by rich experience in locomotion mechanisms for highly rough terrain and advanced slippage control in loose soil environment. Also by 3D map building technology using a laser scanner for autonomous collision avoidance and for operator assistance in remote control/tele-operation. We also contributed to the design and development of Hayabusa and Hayabusa-2, which are sample-return probes developed and operated by Japanese space agency JAXA.
実用化イメージ

These technologies are also applied to terrestrial robots for such as surveillance or disaster response.

Researchers

Graduate School of Engineering

Kazuya Yoshida

[disaster science]

Forecasting eruption transition through geologic and petrologic approaches

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特徴・独自性
  • 1) In addition to geophysical observations, recent advances in volcanic stratigraphy and petrology would make us possible to forecast the transition of volcanic eruptions. We have been developing near-real-time volcanology based on the erupted materials in an early eruption stage.
  • 2) Automation of textural analyses of erupted materials, Risk assessment of volcanic eruption based on eruption stratigraphy
実用化イメージ

Researchers

Graduate School of Science

Michihiko Nakamura

[Disaster-relief]

Robot Technology for Achieving Secure Society

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特徴・独自性
  • Tadokoro Laboratory developed ‘Active Scope Camera,' a world-unique rescue robot that can search deep in rubble piles of collapsed structures through a gap of a few cm wide. It also developed ‘Quince,' a world-unique unmanned ground vehicle that could survey the second to fifth floors of Nuclear Reactor Buildings of Fukushima-Daiichi Nuclear Power Plant. Its technologies was applied industries, including unmanned transfer vehicle for outdoors under ice and snow environment being actually used in a factory of Toyota Motor East Japan, and ‘Robo-Scope' for debris inspection in collaboration with Shimizu Corporation.
実用化イメージ

We have a policy of education through and research for solution to actual problems. Current nearly ten collaborative researches focuses on outdoor investigation, infrastructure/plant inspection, and remote/autonomous task execution by robots.

Researchers

Graduate School of Information Sciences

Satoshi Tadokoro

[disinfectants]

Development and evaluation of various inhibitors and disinfectants for SARS-CoV-2

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特徴・独自性
  • Using the infectious SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), we are evaluating and developing new therapeutic drug candidates as well as evaluating disinfectants. Further analyses such as mechanism of action and resistance may be applicable. Other pathogens, including influenza virus and drug-resistant bacteria, will be examined upon request and discussion. Through joint and collaborative research with domestic and overseas pharmaceutical companies and related companies, we have experience of their clinical application including basic research.
実用化イメージ

We support development and evaluation of various inhibitors and disinfectants for variants of SARS-CoV-2 as well as wild type.

Researchers

International Research Institute of Disaster Science

Eiichi Kodama

[Dislocation]

Quantitative analysis of microstructure in nuclear materials by week-beam scanning transmission electron microscopy

概要

We have developed a technique for quantitative analysis of microstructures (e.g., dislocations and irradiation defect aggregates) of activated and nuclear-burned specimens in the context of the Week Beam Scanning Transmission Electron Microscope (WB-STEM) method, which boasts extremely high measurement accuracy as a quantitative analysis method for lattice defects.
In combination with a dedicated heated sample holder with fully automated temperature measurement and current control in a cartridge-type heating furnace, changes in dislocation microstructure can be dynamically measured in-situ along with a highly reliable temperature history.

従来技術との比較

Conventional TEM methods require expertise in reciprocal space and dislocation theory, but our WB-STEM method is equipped with automatic analysis software for film thickness measurement and dislocation loop feature extraction, making it possible to analyze irradiation defects easily and precisely.

特徴・独自性
  • Since its design, the WB-STEM method has been developed for implementation and on-site repair in radiation controlled areas where nuclear materials are handled, with special aperture and diffraction disc selection equipment, control and analysis software.
  • WB-STEM accepts irradiation defect analysis of activated specimens from all over the world, including RPV monitoring specimens from European reactors and neutron-irradiated materials from US research reactors.
  • It is also used to analyze the properties of iron-containing nuclear fuel simulated debris in decommissioning projects.
実用化イメージ

We support research organizations that currently use transmission electron microscopy to observe microstructures to introduce the WB-STEM method by special modification. We will instruct researchers who have no experience using transmission electron microscopy in the procedure for dislocation analysis.

Researchers

Institute for Materials Research

Kenta Yoshida

[Dissimilar materials]

Design and control of new weld interface during welding of dissimilar materials

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特徴・独自性
  • Welding of dissimilar materials is an important process to manufacture the future structures and devices, but it is hard to produce the high-performance welds because the excessive reaction at the weld interface deteriorates the weld properties. Our group attempts to develop the new dissimilar welding process to yield the new interface with the aimed properties through design and control of interfacial reaction as well as usage of solid-state welding processes, such as friction stir welding and ultrasonic welding.
実用化イメージ

We hope to have collaborative researches with willing companies for practical application of welding of dissimilar materials, including metal/metal and metal/thermoplastic composite, in transportation, infrastructure, and energy industries.

Researchers

Graduate School of Engineering

Yutaka Sato

[Distal myopathy with rimmed vacuoles (DMRV)]

Amyotrophic lateral sclerosis (ALS),Muscular dystrophy,Distal myopathy with rimmed vacuoles (DMRV)/ GNE myopathy

特徴・独自性
  • GNE myopathy, a type of distal myopathy, is a rare disease and a designated intractable disease in which muscles atrophy and degenerate starting from areas distant from the trunk, gradually depriving the body of freedom. Patients with this disease have mutations in the gene for an enzyme called GNE and cannot synthesize sialic acid, including aceneuramic acid. At the Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, a model mouse was created, and preventive effects were obtained through oral administration of aceneuramic acid.
  • In response to this, the field of neurology conducted the world's first physician-initiated Phase I clinical trial in 2010-2011, establishing safety. After physician-initiated Phase II/III trials, extension trials, and efficacy confirmation trials, Nobel Pharma obtained manufacturing and marketing approval for the product named Acenobel® in March 2024. In the future, it is expected that the know-how gained from this seed in creating registries and protocols will be utilized to advance the development of treatments targeting other sialic acid supplements, viral vectors, and oxidative stress.
実用化イメージ

Researchers

Graduate School of Medicine

Masashi Aoki

[distance education]

Advanced Educational Environment with Interactive Instruction System IMPRESSION

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特徴・独自性
  • IMPRESSION is an interactive instruction system for both face-to-face lesson and distance education.
  • It was designed to facilitate teachers to plan and perform effective and attractive lessons with various multimedia materials, and help to evaluate performed lessons and improve them based on the double loop instructional design process, which is focusing on interaction between a teacher and students.
実用化イメージ

It could be used to perform advanced education with multimedia materials in schools, and also to design and implement training for employees at branch offices.

Researchers

Center for Data-driven Science and Artificial Intelligence

Takashi Mitsuishi

[DNA analysis]

Construction of Monitoring Systems for Genetic Diversity in Aquatic Organisms

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特徴・独自性
  • Maintaining genetic diversity within a species is a major issue to conserve biodiversity and sustainable use. To monitor genetic diversity in natural and captive populations using adequate genetic markers is the most important step. We have focused aquatic organisms and studied the genetic diversity using an array of DNA analyses. Our research interest includes 1) genetic structure and phylogeography of natural populations in marine and freshwater organisms and 2) genetic management of commercially important species to contribute the stock enhancement programs.
実用化イメージ

Our skill can be applied to environmental assessment and fish resource management. We are collaborating with national institutes and giving advice to private environmental assessment companies.

Researchers

Graduate School of Agricultural Science

Minoru Ikeda

[DOHaD]

Testing sperm samples from fathers can predict the incidence of autism spectrum disorder in their children

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概要

Autism spectrum markers:
Measuring histone modifications in sperm may be able to predict the risk of neurodevelopmental disorders in the next generation.

従来技術との比較

It is known that the highest risks with regard to the development of developmental disorders in children are ageing and premature birth in both parents, and it has been repeatedly epidemiologically reported that the risk is higher in ageing fathers than in ageing mothers among the parents. Conventionally, sperm are only examined under a microscope to check sperm count, morphology and motility, but not at the molecular level. The present invention is an innovative method that focuses on epigenetic molecular markers.

特徴・独自性
  • While birthrates are falling rapidly, developmental disorders are on the rise
  • Focus on plastic epigenetic molecules as a successional effect of paternal ageing.
  • Sperm testing can be performed non-invasively.
  • Suitable as a quality check for sperm donors etc.
実用化イメージ

The combination of sperm histone modifications and relevant epigenetic factors (DNA methylation, microRNAs) in combination with the sperm panel test will enable highly accurate sperm quality testing.

Researchers

Graduate School of Medicine

Noriko Osumi

[Domestic Students]

Multicultural collaboration and Human Rights Education

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特徴・独自性
  • In this research, students from various backgrounds study human rights together to see whether human rights could be the universal topic for students to start and developing their discussions. Thus, this research is trying to observe students' behavior and check their study outcome.
実用化イメージ

It would be great if I could collaborate with any researchers or associations to do comparative research under the topics of human rights or creating collaborative relationships among students from various backgrounds.

Researchers

Institute for Excellence in Higher Education

Mino Takamatsu

[dried blood powder]

Extraction of cellulose nanofibers (CNFs) from sea pineapples' shells and application for energy materials

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概要

The sea pineapple is the only animal that produces cellulose, and its shells, excluding the edible parts, are treated as industrial waste. By removing proteins and other components from the sea squirt shells and fibrillating them, cellulose nanofibers (CNFs) can be extracted. We have focused on the fact that CNFs derived from sea squirt shells have a higher degree of crystallinity and greater mechanical strength compared to those from wood, and we are exploring various applications of this material. Furthermore, since the material transforms into high-quality carbon upon calcination, we successfully developed "nano-blood carbon catalysts" by mixing it with dried blood powder and calcining the mixture. These catalysts are being applied in fuel cells, water electrolysis, and metal-air batteries.

従来技術との比較

CNFs derived from sea pineapple's shells have a higher degree of crystallinity compared to those from wood and provide longer fibers, resulting in high strength. When calcined, they transform into high-performance carbon.

特徴・独自性
  • We are the only research laboratory that has consistently developed a process for the simple and large-scale purification of CNFs derived from sea pineapple's shells, along with the creation of film materials that leverage their unique properties (mechanical, engineering, surface science, electrical, and thermal characteristics), as well as the development of carbonized materials.
実用化イメージ

We offer materials derived from sea pineapples' shell CNFs, as well as their carbonized products and catalysts. Please feel free to consult us regarding material supply, carbonization processes, or the utilization of catalysts.

Researchers

Advanced Institute for Materials Research

Hiroshi Yabu

[Drone]

Prediction and evaluation of future thermal and wind environments based on CFD, and planning of urban environments adaptable to future climate

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特徴・独自性
  • Numerical simulations of the physical environment of urban outdoor spaces are conducted to predict the physical environment, such as temperature, humidity, wind, and pollutant concentration, and field measurements are conducted to understand the actual physical environment. In addition, the future outdoor environments and heat stroke risks due to global warming are predicted and evaluated.
    Furthermore, the impacts of urban morphology (building shape and layout, street trees, etc.) on the adaptation to severe heat in summer and rare typhoons and floods are evaluated quantitatively.
実用化イメージ

Numerical analysis is used to quantitatively evaluate the "merits and demerits" of designing buildings, planning city blocks and urban areas, and introducing various heat control technologies on the wider thermal environment and the formation of wind ventilation paths, as well as the adverse effects of typhoons and other disasters. The materials for making decisions on whether or not to introduce these technologies are provided.

Researchers

Graduate School of Engineering

Yasuyuki Ishida

[drug]

Innovative anemia therapy: Development of new anemia drugs targeting the novel mechanism of erythropoiesis

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特徴・独自性
  • Strong points
  • Anemia is a very prevalent disease. Nevertheless, an effective therapy is yet to be discovered. Erythropoietin is effective only for those with renal dysfunction. We have found that inhibition of an enzyme for epigenetic regulation results in a prominent increase of erythropoiesis, pointing to a new target for anemia therapy. We have also generated a new, cell-based assay system for the enzymatic activity and carried out small molecule screening.
  • Collaboration with industry partners
  • We are seeking a collaboration to accelerate the development of new anemia drugs based on these findings. Together we will advance the development of the candidate molecules currently identified as well as conduct further screening of larger chemical space for better candidates and/or for drug repositioning.
実用化イメージ

Researchers

Graduate School of Medicine

Kazuhiko Igarashi

[Drug Discovery]

Development of PHD-Targeted Drug for Ischemic Injury

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特徴・独自性
  • All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
  • We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.
実用化イメージ

Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Researchers

Graduate School of Medicine

Toshio Miyata

[Drug Screen]

Exercising "Cultured" Myotubes!

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特徴・独自性
  • We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).
実用化イメージ

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Researchers

Graduate School of Biomedical Engineering

Makoto Kanzaki

[drug-resistant]

The Novel Ultrasound Irradiation Device

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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Research Center for Accelerator and Radioisotope Science

Katsunori Nonogaki