"D" Keywords - 75 Result(s)

 D

[Domestic Students]

Multicultural collaboration and Human Rights Education

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特徴・独自性
  • In this research, students from various backgrounds study human rights together to see whether human rights could be the universal topic for students to start and developing their discussions. Thus, this research is trying to observe students' behavior and check their study outcome.
実用化イメージ

It would be great if I could collaborate with any researchers or associations to do comparative research under the topics of human rights or creating collaborative relationships among students from various backgrounds.

Researchers

Institute for Excellence in Higher Education

Mino Takamatsu

[Dopaminergic neurons]

Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce neural precursor cells from human bone marrow stromal cells by introducing cells with Notch intracellular domain gene plasmid followed by culturing in neurosphere method. This induction system successfully generates neural precursors which were effective for stroke (J. Neuropathol. Exp. Neurol. , 2005; J Cereb Blood Flow Metab, 2009). They could be further developed into dopamine producing neurons by treating them with cytokines including GDNF (J. Clin. Invest, 2004). The efficiency and safety of induced dopamine neurons were confirmed by rat and monkey model of Parkinson's disease. Importantly, long-term survival of auto-transplanted induced dopamine neurons were verified by 11C-CFT PET scan (J. Clin. Invest, 2013).
実用化イメージ

We hope to collaborate with companies and research groups who are willing to utilize our system.

Researchers

Graduate School of Medicine

Mari Dezawa

[Drone]

Hardware Development of Brain Computer and its Application to Visual Information Processing

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特徴・独自性
  • Toward realizing a high-performance neuromorphic vision processing system, our research involves a neural network model of spatial perception based on motion-stereo vision and its implementation on a very large scale integrated circuit (VLSI). Important parameters for spatial perception such as time-to-contact, orientation, and the shortest distance to plane surfaces of a target object are recognized by using the model without knowing moving direction and velocity of the object. We have developed a VLSI capable of performing visual perception based on the model with low power consumption, reduced less than 1/100 compared with a commercial CPU.
実用化イメージ

Targeted applications include a drone flying autonomously equipped with collision avoidance system by visual perception. Targeted industry includes infrastructure inspection, agriculture, logistics, and so on.

Researchers

Research Institute of Electrical Communication

Shigeo Sato

Prediction and evaluation of future thermal and wind environments based on CFD, and planning of urban environments adaptable to future climate

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特徴・独自性
  • Numerical simulations of the physical environment of urban outdoor spaces are conducted to predict the physical environment, such as temperature, humidity, wind, and pollutant concentration, and field measurements are conducted to understand the actual physical environment. In addition, the future outdoor environments and heat stroke risks due to global warming are predicted and evaluated.
    Furthermore, the impacts of urban morphology (building shape and layout, street trees, etc.) on the adaptation to severe heat in summer and rare typhoons and floods are evaluated quantitatively.
実用化イメージ

Numerical analysis is used to quantitatively evaluate the "merits and demerits" of designing buildings, planning city blocks and urban areas, and introducing various heat control technologies on the wider thermal environment and the formation of wind ventilation paths, as well as the adverse effects of typhoons and other disasters. The materials for making decisions on whether or not to introduce these technologies are provided.

Researchers

Graduate School of Engineering

Yasuyuki Ishida

[drug]

Innovative anemia therapy: Development of new anemia drugs targeting the novel mechanism of erythropoiesis

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特徴・独自性
  • Strong points
  • Anemia is a very prevalent disease. Nevertheless, an effective therapy is yet to be discovered. Erythropoietin is effective only for those with renal dysfunction. We have found that inhibition of an enzyme for epigenetic regulation results in a prominent increase of erythropoiesis, pointing to a new target for anemia therapy. We have also generated a new, cell-based assay system for the enzymatic activity and carried out small molecule screening.
  • Collaboration with industry partners
  • We are seeking a collaboration to accelerate the development of new anemia drugs based on these findings. Together we will advance the development of the candidate molecules currently identified as well as conduct further screening of larger chemical space for better candidates and/or for drug repositioning.
実用化イメージ

Researchers

Graduate School of Medicine

Kazuhiko Igarashi

[Drug delivery system]

Image Guided Local Drug Delivery for Central Nervous System Disorders

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特徴・独自性
  • Effective drug delivery to central nervous system is promising as a new therapeutic strategy against various central nervous system disorders. However, it represents a challenge because systemic delivery is always hindered by blood brain barrier, and local delivery cannot be effective because of the restricted distribution. Recently, local drug delivery system that can achieve robust distribution of the infusates by maintaining a pressure gradient at the tip of the infusion catheter during infusion has developed. Although this method is promising, there still exist several problems as loss of infusates by backflow through catheter tract or inconsistent distribution. We recently developed a method to deliver agents with this method under MRI guidance, and now performing clinical trial to treat recurrent gliomas.
実用化イメージ

Focal central nervous system disorders such as tumor, epilepsy, and parkinson's disease can be the target for application of this technique. Developments of the new catheters and pre-infusional similation systems are on their way. We are searching for effective collaborative research in this field.

Researchers

Administrative Staff

Teiji Tominaga

[Drug design]

MEDICINE DETERMINATION SUPPORT SYSTEM AND MEDICINE DETERMINATION SUPPORT PROGRAM

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特徴・独自性
  • AIMS: This invention is to support the doctor’s prescription for diabetes and metabolic syndrome, especially in Japanese Clinic (Patent: JP 4176438).
  • PROBLEM TO BE SOLVED: To perform a further efficient preparation by providing information for original medicine and generic medicine in the preparation.
  • SOLUTION: The medicine price, pharmacologic effect and the like of each of original medicine and generic medicine are preliminarily recorded in a medicine database, and a generic medicine corresponding to the original medicine inputted by a doctor is automatically retrieved and displayed on a display. When the total number of the inputted medicine exceeds a number determined by insurance medical care, the generic medicine is retrieved so that the drug price of the group of the same usage is a prescribed amount or less. Welcome to your investment or co-operation.
実用化イメージ

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[Drug Discovery]

Development of PHD-Targeted Drug for Ischemic Injury

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特徴・独自性
  • All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
  • We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.
実用化イメージ

Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Researchers

Graduate School of Medicine

Toshio Miyata

[Drug Screen]

Exercising "Cultured" Myotubes!

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特徴・独自性
  • We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).
実用化イメージ

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Researchers

Graduate School of Biomedical Engineering

Makoto Kanzaki

[drug-resistant]

The Novel Ultrasound Irradiation Device

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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[Dry]

Dry-Contact Ultrasonic Technique

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特徴・独自性
  • A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering Department of Finemechanics

TOHMYOH Hironori

[ductility]

Advanced Control of Microstructure and Property of Structural Metallic Materials

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特徴・独自性
  • Microstructure represents various kinds of heterogeneities in the metallic materials, i.e., grains, component phase, lattice defects and chemical inhomogeneity such as impurity/alloying elements. It can be modified through control of phase transformation/precipitation and deformation/recrystallization by adjusting compositions of materials and/or through processing routes (heat treatment, deformation). Such expertise in micro/nanostructure control is very important in production of current materials from viewpoints of energy saving and recycling in structural materials such as steels and titanium alloys.
  • We attempt to apply more advanced control of micro/nanostructures, such as atomic structures of crystalline interfaces, chemistory in an atomic scale (e.g., segregation) and so on. Fundamentals of microstructure formation (thermodynamics, kinetics, crystallography) are examined both theoretically and experimentally to clarify key factors for microstructure control. Another important aspect in our research is the improvement of mechanical property by microstructure manipulation.
実用化イメージ

Possibilities to establish new functions (e.g., superplasticity, shape memory/superelasticity) as well as superior mechanical properties (e.g., ultrahigh strength with high toughness/ductility) is also explored.

Researchers

Institute for Materials Research

Tadashi Furuhara

[durability]

[Dynamic Cardiac Property]

Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries

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特徴・独自性
  • Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured by CT, MRI, SPECT, or conventional ultrasound. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions (US patent 5840028), we have detected the minute mechanical response (velocity component) to the propagation of the action potential in the human heart or to detect the propagation of the vibrations along the heart wall caused by the valve closure (Fig. 2).
  • By applying the same procedure to the human arteries, the regional change in wall thickness caused during one cardiac cycle can be measured with high spatial resolution (Fig. 1). From the measurement, the regional elasticity of tissue surrounding atherosclerotic plaque can be determined. By comparing the pathological findings with the distribution of elasticity, elasticity of lipid and that of fibrous tissue were determined. Thus, each point inside the plaque is classified into lipid or fibrous tissue using transcutaneous ultrasound (Fig. 3).
実用化イメージ

This novel method offers potential as a diagnostic technique for detection of plaque vulnerability with high spatial resolution.
We are prepared to provide academic consultations to companies interested in our research.

Researchers

Graduate School of Engineering

Hiroshi Kanai

[dysprosium]

Magnetic Materials (Permanent Magnets, High Frequency Materials, Microwave Absorbers)

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特徴・独自性
  • The objectives of my researches are the development of high performance magnets and improvement of their magnetic properties. I have already developed following high performance magnets, such as Nd-Fe-B magnets using didymium, Sm-Fe-N high coercive powders prepared by HDDR and Fe-Cr-Co magnets. Recently, I have studied about the reduction of Dy content in Nd-Fe-B magnets for the use of HEV and have succeeded to develop high coercive Dy-free Nd-Fe-B sintered magnets by decreasing the grain size. I have also developed new kinds of microwave absorbers for the use in the frequencies of GHz range using permanent magnetic materials or nanoparticles.
実用化イメージ

High performance magnetic materials can be used in many applications in automobile, home electronics, IT and medical industries. We hope to conduct collaborative researches with companies producing magnetic materials for the use in these applications, which aims to improve magnetic properties or to develop new magnetic materials.

Researchers

Graduate School of Engineering

Satoshi Sugimoto