"N" Keywords - 81 Result(s)
N
[N-acetylneuraminic acid]
Amyotrophic lateral sclerosis (ALS),Muscular dystrophy,Distal myopathy with rimmed vacuoles (DMRV)/ hereditary inclusion body myopathy (hIBM)FeaturesDistal myopathy with rimmed vaculoles (DMRV) / hereditary inclusion body myopathy (hIBM) is an autosomal recessive disorder characterized clinically by the preferential involvement of the tibialis anterior muscle. It is known that the disease gene underlying DMRV is GNE, encoding glucosamine (UDP-N-acetyl)-2- epimerase and N-acetylmannosamine kinase, two essential enzymes in sialic acid biosynthesis. Decreased sialic acid production causes muscle degeneration. Muscle atrophy and weakness are completely prevented in a mouse model of DMRV after treatment with sialic acid metabolites orally. Department of Neurology, Graduate School of Medicine
AOKI Masashi, Professor
Doctor of Medicine
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[nano particle]
Monomer-Recycle System of Biodegradable Plastics by Industrial Fungal Fermentation and Application of Fungal Biosurfactant Proteins to Nanoparticles for Medical UseFeaturesIn Japan, solid-phase fungal fermentation systems using the industrial fungus Aspergillus oryzae have been extensively used for producing fermented foods such as soy sauce and sake; the annual production volume of the products is over one million tons. The efficient enzymatic hydrolyzing systems are expected to be applicable to biological recycling of biodegradable plastics. We found that A. oryzae can effectively degrade polybutylene succinate-coadipate (PBSA) by the combination with an esterase (cutinase) CutL1 and novel surfactant proteins, RolA and HsbA that are attached to the surface of PBSA and then recruit CutL1. The recruitment of Cutl1 by the surfactants stimulated PBSA degradation. Targeted Application(s)/IndustryThe fungal biosurfactant protein is applicable to industrial recycling of biodegradable plastics and to production of immune-response free nano-particles for medical use. |
[nano pigments]
Fabrication of The Novel Designed Nanodrugs Composed of Poorly Water-Soluble CompoundsFeaturesOne of our major research focuses is to design the novel drug nanoparticles, so called “Nano-prodrugs”, and to apply them as anticancer drugs or eye drops with excellent delivery efficiency. Nano-prodrugs are constructed by synthetic prodrugs molecules which contains poorly water-soluble substituent. They could be fabricated to nanoparticles with 100 nm or less in size by our reprecipitation technique, which has been used to create organic nanomaterials. We are aiming at practical application of our Nano-prodrugs in the near future. Targeted Application(s)/IndustryOur reprecipitation technique for fabricating organic nanomaterials is a versatile technique that can be applied to various organic molecules as well as drug compounds. We hope to conduct collaborative research with a willing company on controlling and evaluating properties of the organic nanoparticles. Institute of Multidisciplinary Research for Advanced Materials
KASAI Hitoshi, Professor
Doctor of Science
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[Nano-carbon]
Synthesis of Novel Nano-Carbon Materials Using Nano-Space as a Reaction FieldFeaturesWe are designing and developing novel nanocarbon materials together with their hybrids by controlling the reaction nano-fields for the syntheses of these materials. One example is fully tailored carbon nanotubes with uniform diameter and length. Another noteworthy material is zeolite-templated carbon which has structure regularity like zeolite and a surprisingly large surface area up to 4000 m2/g. In addition, we have recently developed a method for a complete coating of the entire surface of mesoporous silica with graphene layers. Targeted Application(s)/IndustryWe are trying to apply these unique nanomaterials to electronic device, electrochemical capacitors, lithium-ion batteries, hydrogen storage, biosensors and capsules for drug and gene delivery. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. Institute of Multidisciplinary Research for Advanced Materials
KYOTANI Takashi, Professor
Doctor of Engineering
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[nano-drugs]
Fabrication of The Novel Designed Nanodrugs Composed of Poorly Water-Soluble CompoundsFeaturesOne of our major research focuses is to design the novel drug nanoparticles, so called “Nano-prodrugs”, and to apply them as anticancer drugs or eye drops with excellent delivery efficiency. Nano-prodrugs are constructed by synthetic prodrugs molecules which contains poorly water-soluble substituent. They could be fabricated to nanoparticles with 100 nm or less in size by our reprecipitation technique, which has been used to create organic nanomaterials. We are aiming at practical application of our Nano-prodrugs in the near future. Targeted Application(s)/IndustryOur reprecipitation technique for fabricating organic nanomaterials is a versatile technique that can be applied to various organic molecules as well as drug compounds. We hope to conduct collaborative research with a willing company on controlling and evaluating properties of the organic nanoparticles. Institute of Multidisciplinary Research for Advanced Materials
KASAI Hitoshi, Professor
Doctor of Science
|
[nano-imaging]
Highly Functional Semiconductor Lasers and Nanoimaging ApplicationsFeaturesWe are pursuing the ultimate functions of semiconductor lasers and their application potentials. Concerning the application research aspect, development of advanced biomedical technologies, in which photonic methods play key roles, is an important issue. Such applied science field is called to be biophotonics, and a goal of our biophotonics research is to accomplish a high-resolution imaging for very deep sites of bio-tissues by employing nonlinear optical effects. Another important issue is the super-resolution "nanoimaging", which can provide nanometer-scale spatial resolution images by optical methods. Targeted Application(s)/IndustryRegarding academic-industrial cooperative research subjects, we expect to produce novel functional light sources that are compact, stable, cost effective, and thus widely usable for real world applications. Advanced biomedical measurement and diagnostic systems with these light sources will be also developed. New Industry Creation Hatchery Center (NICHe)
YOKOYAMA Hiroyuki, Professor
Doctor of Engineering
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[Nano-rheology]
Development of Nano-Interface Chemistry for Materials Sciences Using Surface Forces MeasurementFeaturesOur research aims at developing methods, including instrumentation, for characterizing surface (or interface) at the nano-meter level. Most of our research subjects are related to the surface forces measurement, which can directly monitor the interaction between two surfaces. We study phenomena occurring at the solid-liquid interface such as adsorption and structuring of liquids. We have developed the resonance shear measurement which is a sensitive method for evaluating properties of confined liquid for nano-rheology and tribology. Twin-path surface forces apparatus we developed enabled us to study wide variety of samples such as metals, ceramics and plastics. Targeted Application(s)/IndustryThese methods are applicable for characterizing lubricants, nano-materials, paints, sealants, and cosmetics. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. Institute of Multidisciplinary Research for Advanced Materials
KURIHARA Kazue, Professor
Doctor of Engineering
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[nano-scale analysis of materials]
Analysis and Function Elucidation of Fine Clusters and Defects in Materials Invisible by Electron MicroscopyFeaturesIt is well known that nano-scale impurity/solute clusters, defects, defect clusters and their complexes affect the mechanical and electrical properties in materials. However, it is very difficult to observe these objects even by state-of-the-art electron microscopes. We overcome the difficulty by employing noble two techniques: laser three-dimensional atom probe (3D-AP) technique and positron annihilation spectroscopy (PAS). Laser 3D-AP can map out each atom in various materials (metals, semiconductors, insulators) in three-dimensional real space with nearly atomic scale resolution. PAS can detect vacancy-type defects and defect-impurity complexes very sensitively. Targeted Application(s)/IndustryBy combining these methods, we are going to reveal the functions of the fine impurity clusters and defects to the materials: developments of new nano-structured materials, the mechanism of degradation of aged structural materials, the fall in the yield of semiconductor device production, and developments of quantum devices etc. |
[Nano-Tribology]
Development of Nano-Interface Chemistry for Materials Sciences Using Surface Forces MeasurementFeaturesOur research aims at developing methods, including instrumentation, for characterizing surface (or interface) at the nano-meter level. Most of our research subjects are related to the surface forces measurement, which can directly monitor the interaction between two surfaces. We study phenomena occurring at the solid-liquid interface such as adsorption and structuring of liquids. We have developed the resonance shear measurement which is a sensitive method for evaluating properties of confined liquid for nano-rheology and tribology. Twin-path surface forces apparatus we developed enabled us to study wide variety of samples such as metals, ceramics and plastics. Targeted Application(s)/IndustryThese methods are applicable for characterizing lubricants, nano-materials, paints, sealants, and cosmetics. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. Institute of Multidisciplinary Research for Advanced Materials
KURIHARA Kazue, Professor
Doctor of Engineering
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[nano&heterostructure]
Development of Terahertz Semiconductor Devices Using Novel Nano-Heterostructures and Materials and their ICT ApplicationsFeaturesTerahertz coherent electromagnetic waves are expected to explore the potential application fields of future information and communications technologies. We are developing novel, ultra-broadband integrated signal-processing devices/systems operating in the terahertz frequency regime employing novel semiconductor nano-heterostructures and materials. We are challenging to develop room-temperature operating coherent and intense laser transistors and fast-response and highly sensitive detectors working for the next-generation beyond-5G terahertz wireless communications as well as safety and security terahertz imaging applications. Targeted Application(s)/IndustryBy making full use of these world-leading device/circuit technologies, we are exploring future ultra-broadband 6G- and 7G-class wireless communication systems as well as spectroscopic/imaging systems for safety and security. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. Research Institute of Electrical Communication
OTSUJI Taiichi, Professor
Doctor of Engineering
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[nanocomposite]
Magnetic Materials (Permanent Magnets, High Frequency Materials, Microwave Absorbers)FeaturesThe objectives of my researches are the development of high performance magnets and improvement of their magnetic properties. I have already developed following high performance magnets, such as Nd-Fe-B magnets using didymium, Sm-Fe-N high coercive powders prepared by HDDR and Fe-Cr-Co magnets. Recently, I have studied about the reduction of Dy content in Nd-Fe-B magnets for the use of HEV and have succeeded to develop high coercive Dy-free Nd-Fe-B sintered magnets by decreasing the grain size. I have also developed new kinds of microwave absorbers for the use in the frequencies of GHz range using permanent magnetic materials or nanoparticles. Targeted Application(s)/IndustryHigh performance magnetic materials can be used in many applications in automobile, home electronics, IT and medical industries. We hope to conduct collaborative researches with companies producing magnetic materials for the use in these applications, which aims to improve magnetic properties or to develop new magnetic materials. Department of Materials Science, Graduate School of Engineering
SUGIMOTO Satoshi, Professor
Doctor of Engineering
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Multi-functionalization of composite materials by microstructure designFeaturesFor further social development, it is required the miniaturization, weight saving, high performance of various devices. We study on fiber, particle reinforced polymer, metal, ceramic matrices composite materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop multi-functionalized composite materials, which have high strength, super lightweight, energy harvesting function, damage monitoring function, biodegradable at the same time. Targeted Application(s)/IndustryDepartment of Materials Processing, Graduate School of Engineering
KURITA Hiroki, Assistant Professor
Doctor of Engineering
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[Nanocrystalline alloy]
Development of Soft Magnetic Materials and Magnet Consisting of Complete Rare-Earth Free Elements Both with Ultimately-High-Efficient Types Contributing to Energy- and Resource-Saving by Precise Controlling their NanostructuresFeaturesFeatures and Originalities Targeted Application(s)/Industry |
[nanodevice]
Development of Innovative Green Nanodevices Using Damage-Free ProcessesFeaturesWe developed an entirely new concept of "bio-template ultimate process technology" and realized fabrication of uniform, size-controllable, defect-free, high-density and regularly-distributed quantum dot array on surface of arbitrary material. The quantum dot array can be applied to high efficiency and inexpensive quantum dot solar cells, high luminescence quantum dot lasers, high-speed graphene / germanium transistors, and so on, i.e., energy-generating, energy-storing, and low-energy-consumption devices. Targeted Application(s)/IndustryWe can accept collaborative researches on nanodevices such as quantum dot solar cells or lasers, low-energy-consumption devices such as graphene transistor and germanium transistor, and fundamental technologies such as plasma/beam processes, thin film deposition, doping, and surface treatment. Green Nanotechnology Laboratory, Innovative Energy Research Center, Institute of Fluid Science
SAMUKAWA Seiji, Professor
Doctor of Engineering
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Electronic properties of nanostructures and nanodevicesFeatures1) We investigate interesting properties of nanostructures and develop materials and devices utilizing nanostructures. Targeted Application(s)/IndustryResearch Institute of Electrical Communication
OTSUKA Tomohiro, Associate Professor
Doctor of Science
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[nanoimaging]
Development of Vector Beam and its Application to NanoimagingFeaturesVector beams are very attractive because of their unique features such as small spot formation and strong longitudinal electric field near focus. We are developing a variety of generation methods of vector beams including Laguerre-Gaussian and Bessel-Gaussian beams and their higher order transverse modes. For instance, a smaller spot by approximately 30 % than that by a linearly polarized beam has been demonstrated and applied for nanoimaging. Targeted Application(s)/IndustryConfocal scanning microscpy will benefit from vector beams as enhancement of spatial resolution. Otherwise, precision nano-processing will be possible. We are prepared to provide academic consultations to companies interested in our research. Institute of Multidisciplinary Research for Advanced Materials
SATO Shunichi, Professor
Doctor of Engineering
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[Nanoimprint]
Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine MicrostructuresFeaturesIn our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.
Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers. Surface-smoothing technology using surface self-diffusion. Study of low loss silicon nanophotonic devices. Targeted Application(s)/IndustryWe aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed. |
[nanoimprint lithography]
Photo-Functional Advanced Materials for Nanofabrication by Nanoimprint LithographyFeaturesNakagawa group has dedicated to pursue scientific principles for molecular control of interface function occurring at polymer/other material interfaces and to put them into practice in nanoimprint lithography promising as a next generation nanofabrication tool. We are developing advanced photo-functional materials such as sticking molecular layers for "fix by light", UV-curable resins and antisticking molecular layers for "preparation by light", fluorescent resist materials for "inspection by light", and hybrid optical materials "available to light" and new research tools such as mechanical measurement systems to evaluate release property of UV-curable resins. Targeted Application(s)/IndustryOur research aims at creating new devices to control photon, electron, and magnetism. Institute of Multidisciplinary Research for Advanced Materials
NAKAGAWA Masaru, Professor
Doctor of Engineering
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[Nanomaterials]
Advanced Nanotechnology for Critical metal free secondary batteryFeaturesMonoatomic layered materials of Graphene, Transition metal sulfide nanosheet, nanocrystalline active materials, nanoparticles and nanoporous materials are investigated for realizing high capacity, high power, high safety and low cost energy storage devices as a post- Lithium ion battery. Advanced chemistry of functional materials and device processes for All solid state battery, Magnesium battery, fuel cells, supercapacitor and wearable batteries are investigated. Targeted Application(s)/IndustryAcademia – Industry collaboration with manufacturing companies of functional materials, batteries, and also smart grid, renewable energy, electrical power companies are encouraged for developments of advanced energy materials and post-Lithium ion battery. Institute of Multidisciplinary Research for Advanced Materials
HONMA Itaru, Professor
Doctor of Engineering
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[nanoparticle]
Nanoparticle synthesis by femtosecond laser pulsesFeaturesBy using femtosecond laser pulses, nanoparticles of noble metals (gold, platinum, silver, palladium etc.) are synthesized. Particles with the size of a few nanometers are fabricated by simply irradiating metal ion solution with the laser pulses. This process needs no reducing agent and is able to synthesize alloy nanoparticles of noble metals. The collection of nanoparticles is easy because the process is performed in liquid. We are prepared to provide academic consultations to companies interested in our research. Targeted Application(s)/IndustryInstitute of Multidisciplinary Research for Advanced Materials
SATO Shunichi, Professor
Doctor of Engineering
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