"N" Keywords - 59 Result(s)

 N

[Nanostructure]

Development of Nano-Interface Chemistry for Materials Sciences Using Surface Forces Measurement

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特徴・独自性
  • Our research aims at developing methods, including instrumentation, for characterizing surface (or interface) at the nano-meter level. Most of our research subjects are related to the surface forces measurement, which can directly monitor the interaction between two surfaces. We study phenomena occurring at the solid-liquid interface such as adsorption and structuring of liquids. We have developed the resonance shear measurement which is a sensitive method for evaluating properties of confined liquid for nano-rheology and tribology. Twin-path surface forces apparatus we developed enabled us to study wide variety of samples such as metals, ceramics and plastics.
実用化イメージ

These methods are applicable for characterizing lubricants, nano-materials, paints, sealants, and cosmetics. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

New Industry Creation Hatchery Center

Kazue Kurihara

Electronic properties of nanostructures and nanodevices

特徴・独自性
  • 1) We investigate interesting properties of nanostructures and develop materials and devices utilizing nanostructures.
  • 2) We have techniques and skills on low-noise electric measurements, cryogenics, nanofabrication, and data informatics. We are open to new collaborations.
実用化イメージ

Researchers

Advanced Institute for Materials Research

Tomohiro Otsuka

[Natural Crack]

Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation Techniques

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特徴・独自性
  • The emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding.
実用化イメージ

The method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for.

Researchers

Graduate School of Engineering

Noritaka Yusa

[natural language assessment ]

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

[natural language processing]

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

[Natural Product Chemistry]

Development of New Reactions Using Organocatalyst

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特徴・独自性
  • Organocatalyst is a synthetically useful catalyst in synthetic organic chemistry, because of the several merits. We have been investigating the development of new and efficient organocatalysts derived from proline. We have already reported the diphenylprolinol silyl ether, which is called as a Jorgensen-Hayashi catalyst, and siloxyproline, which is effective in the presence of water. We have also developed several practical asymmetric catalytic reactions based on the organocatalysts. We also applied these reactions to the total synthesis of natural products and drugs. We have already synthesized Tamiflu in one-pot reaction, and prostaglandin E1 methyl ester via three one-pot procedure.
実用化イメージ

Our newly developed reactions using organocatalysis can be widely used for synthesis of medicines, agrichemicals, and chemical products.

Researchers

Graduate School of Science

Yujiro Hayashi

[NDT]

Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation Techniques

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特徴・独自性
  • The emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding.
実用化イメージ

The method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for.

Researchers

Graduate School of Engineering

Noritaka Yusa

[network analyzer]

A Microwave-Based Non-Destructive Testing Method for the Long Range Inspection of Metallic Pipe

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特徴・独自性
  • We are developing a non-destructive testing method for the long range rapid inspection of metallic pipe using microwaves. The method propagates a microwave inside a pipe, and evaluates flaws appearing at the inner surface of the pipe on the basis of the reflection and transmission of the microwave. The method does not require scanning probes unlike conventional non-destructive methods, which enables one to inspect a pipe quite quickly. Our experimental validations have demonstrated the effectiveness of the method using a pipe as long as 30 m.
実用化イメージ

The NDT method proposed here is applicable when many pipes are inspected or conventional methods are not available due to pipe length and its configuration.

Researchers

Graduate School of Engineering

Hidetoshi Hashizume

[Network Theory]

newData science-based analysis for unsteady aerodynamic flows

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概要

Our group studies a range of unsteady flow phenomena leveraging data science, nonlinear machine learning, complex network theory, information theory, and computational fluid dynamics. Our ultimate goal is to build a data-oriented foundation for real-time analysis, modeling, and control of unsteady flows ubiquitously appearing in various situations around small air vehicles, airplanes, motor vehicles, and fluid-based industrial machines.

従来技術との比較

Equipped with nonlinear machine learning-based sparse sensor reconstruction and data compression supported through traditional numerical and experimental analysis, our approach enables high-resolution reconstruction, real-time prediction, and control of flow fields with limited availability of data.
These techniques are aimed at analyzing and controlling large-scale, complex nonlinear flow phenomena that have been challenging to tackle with conventional linear methods.

特徴・独自性
  • ・Real-time spatiotemporal flow field reconstruction from sparse sensors is enabled by turbulence super-resolution analysis with machine learning.
  • ・Understanding and modeling of unsteady fluid flows at low cost is made possible through low-dimensional manifold identification and compression.
  • ・Development of explainable machine-learning approaches for analyzing causal vortex interactions based on complex network theory and information theory.
  • ・Multi-modal data analysis through the fusion of numerical, experimental, and theoretical data.
実用化イメージ

Our group aims to develop technologies that accurately sense, predict, model, and control fluid flows —such as air and water— around objects including airplanes, automobiles, and wind turbines, even with sparse sensor information.

These technologies can contribute to society in various ways, including:
・Improving fuel efficiency and safety of aircraft
・Enhancing the aerodynamic performance of vehicles for energy savings
・Supporting disaster prevention through wind flow prediction during emergencies

We actively seek to co-create innovations through joint research with industrial companies interested in the following areas:

・Predicting and controlling fluid flows using AI and machine learning
・Understanding flow structures through information theory and network science
・Building highly accurate and reproducible models by integrating traditional fluid dynamics with modern data-driven methods

Equipped with physics-based nonlinear machine learning, we are working to develop groundbreaking fluid analysis technologies that benefit a wide range of industrial, environmental, and societal applications.

Researchers

Department of Aerospace Engineering, Graduate School of Engineering

Kai Fukami

[Network-on-CHip]

High-speed and low-power asynchronous Network-on-Chip system based multiple-valued current-mode logic

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特徴・独自性
  • Global intra-chip interconnection complexity not only limits the clock frequency, but causes clock-skew problems in synchronous system. Asynchronous control-based circuit design, where timing is managed locally, is one of the possible approaches to solve the above serious interconnection problem because the asynchronous design has many features which are low power dissipation, high speed and robustness. However, communication-steps overhead caused by handshaking much would generally affect the cycle time.
  • In our approach, a high-speed asynchronous data-transfer scheme is proposed based on multiple-valued encoding and current-mode circuits. The multiple-valued encoding enables to improve communication protocol essentially. Moreover, the current-mode circuits which has high-driving capability makes it possible to perform high-speed intra- and inter-chip network. By using this method, we expect that we can conduct effective collaborative research in high-speed and low-power communication LSIs such as a many-core LSI and a multi-module NoC.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Takahiro Hanyu

[neural regeneration]

Specializes in clinical neurology, particularly neurodegenerative diseases and skeletal muscle diseases, and clinical genetics, and engaged in drug discovery and translational research for patients with intractable neuromuscular diseases.

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概要

Amyotrophic lateral sclerosis (ALS) is a representative intractable neurodegenerative disease, and the development of effective therapies is desired. A novel phase I trial of intrathecal administration of recombinant HGF protein was conducted at Tohoku University Hospital. Based on the results, a phase II trial (investigator-initiated clinical trial) to confirm efficacy and safety for ALS was conducted and completed at the Tohoku and Osaka University Hospital from 2016 to 2022. Although there was no statistically significant difference in the primary endpoint, additional analyses are currently ongoing. Clinical development of the same formulation for acute spinal cord injury is also underway.

従来技術との比較

Simultaneous development of a novel intrathecal formulation of recombinant HGF protein, and a medical device (a subcutaneous port with an intrathecal catheter) that enable repeated intrathecal administration for efficient and selective delivery to the central nervous system.

特徴・独自性
  • We developed a novel rat model of ALS model (Nagai M, et al. 2001)
  • Intrathecal continuous administration of HGF protein was confirmed to have a slowing effect on progression in this model
  • Phase I and II clinical trials have been completed, and the efficacy is currently being verified through additional analysis
実用化イメージ

We have been working with Kringle Pharma, Inc., Keio University (Prof. Hideyuki Okano and Prof. Masaya Nakamura), and Asahikawa Medical University (Prof. Hiroshi Funakoshi) to develop this drug. Phase I and II clinical trials for ALS have been completed. In addition, a phase III clinical trial for acute spinal cord injury is near completion. Additional collaboration with pharmaceutical companies is planned.

Researchers

Graduate School of Medicine

Masashi Aoki

[Neurodegeneration]

Specializes in clinical neurology, particularly neurodegenerative diseases and skeletal muscle diseases, and clinical genetics, and engaged in drug discovery and translational research for patients with intractable neuromuscular diseases.

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概要

Amyotrophic lateral sclerosis (ALS) is a representative intractable neurodegenerative disease, and the development of effective therapies is desired. A novel phase I trial of intrathecal administration of recombinant HGF protein was conducted at Tohoku University Hospital. Based on the results, a phase II trial (investigator-initiated clinical trial) to confirm efficacy and safety for ALS was conducted and completed at the Tohoku and Osaka University Hospital from 2016 to 2022. Although there was no statistically significant difference in the primary endpoint, additional analyses are currently ongoing. Clinical development of the same formulation for acute spinal cord injury is also underway.

従来技術との比較

Simultaneous development of a novel intrathecal formulation of recombinant HGF protein, and a medical device (a subcutaneous port with an intrathecal catheter) that enable repeated intrathecal administration for efficient and selective delivery to the central nervous system.

特徴・独自性
  • We developed a novel rat model of ALS model (Nagai M, et al. 2001)
  • Intrathecal continuous administration of HGF protein was confirmed to have a slowing effect on progression in this model
  • Phase I and II clinical trials have been completed, and the efficacy is currently being verified through additional analysis
実用化イメージ

We have been working with Kringle Pharma, Inc., Keio University (Prof. Hideyuki Okano and Prof. Masaya Nakamura), and Asahikawa Medical University (Prof. Hiroshi Funakoshi) to develop this drug. Phase I and II clinical trials for ALS have been completed. In addition, a phase III clinical trial for acute spinal cord injury is near completion. Additional collaboration with pharmaceutical companies is planned.

Researchers

Graduate School of Medicine

Masashi Aoki

[Neuroimaging]

Brain Mechanism Realizing Human Mind

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特徴・独自性
  • I am investigating the brain mechanism of human mind. Specifically, my target is the internal schema that dissociate the self and other in the following three layers: physical, interpersonal, and social domains.
実用化イメージ

  • Improvement of the interface of the system
  • Clarifying the neuro-cognitive mechanism of the effect on the customer
  • New concept of the customer satisfaction

Researchers

Institute of Development, Aging and Cancer

Motoaki Sugiura

[Neuromorphic computing]

Spintronics device

特徴・独自性
  • To realize ultralow-power and high-performance integrated circuit and information processing, spintronics physics, material, devices are studied.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Shunsuke Fukami

[Neurophysiology]

Analysis of Biological Signals and Visualization

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特徴・独自性
  • Recent development of sensor technology and ICT have enabled collection and acculumation of huge amount and wide variety of biological data. We have been investigating analysis and processing methods of the biological data for supporting clinical diagnosis and health care. For example, development of extraction algorithm of fetal electrocardiogram from maternal abdominal siglnals, and estimation and visualization algorithms of status of autonomic functions based on diverse biological signals.
実用化イメージ

System development of biosignal anaysis, visualization, and diagnosis.
Development of monitoring and evaluation methods of alertness and sleepiness of traffic driver and workers.
Shift work scheduling based on circadian clock.

Researchers

Unprecedented-scale Data Analytics Center

Mitsuyuki Nakao

[Neuroscience]

Functional and Molecular Imaging with Positron Emission Tomography (PET)

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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Research Center for Accelerator and Radioisotope Science

Manabu Tashiro

[neurotrophic factor]

Specializes in clinical neurology, particularly neurodegenerative diseases and skeletal muscle diseases, and clinical genetics, and engaged in drug discovery and translational research for patients with intractable neuromuscular diseases.

NEXT
PREV
概要

Amyotrophic lateral sclerosis (ALS) is a representative intractable neurodegenerative disease, and the development of effective therapies is desired. A novel phase I trial of intrathecal administration of recombinant HGF protein was conducted at Tohoku University Hospital. Based on the results, a phase II trial (investigator-initiated clinical trial) to confirm efficacy and safety for ALS was conducted and completed at the Tohoku and Osaka University Hospital from 2016 to 2022. Although there was no statistically significant difference in the primary endpoint, additional analyses are currently ongoing. Clinical development of the same formulation for acute spinal cord injury is also underway.

従来技術との比較

Simultaneous development of a novel intrathecal formulation of recombinant HGF protein, and a medical device (a subcutaneous port with an intrathecal catheter) that enable repeated intrathecal administration for efficient and selective delivery to the central nervous system.

特徴・独自性
  • We developed a novel rat model of ALS model (Nagai M, et al. 2001)
  • Intrathecal continuous administration of HGF protein was confirmed to have a slowing effect on progression in this model
  • Phase I and II clinical trials have been completed, and the efficacy is currently being verified through additional analysis
実用化イメージ

We have been working with Kringle Pharma, Inc., Keio University (Prof. Hideyuki Okano and Prof. Masaya Nakamura), and Asahikawa Medical University (Prof. Hiroshi Funakoshi) to develop this drug. Phase I and II clinical trials for ALS have been completed. In addition, a phase III clinical trial for acute spinal cord injury is near completion. Additional collaboration with pharmaceutical companies is planned.

Researchers

Graduate School of Medicine

Masashi Aoki

[neutrino observation]

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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特徴・独自性
  • Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.
実用化イメージ

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Researchers

Research Center for Neutrino Science

Kunio Inoue

[neutron beam]

Development of the cyclotron accelerator and its application

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特徴・独自性
  • We develop technology of the cyclotron accelerator and its application as follows. 1)Ion source (particularly heavy ion source), 2)design of ion optics, 3)device control system for the cyclotron, 4)RF system, 5)detectors for charged particles, gamma ray, and neutron, 6) radiation test by ion and neutron beam.
実用化イメージ

We have beam lines dedicated to the neutron irradiation and the ion irradiation, respectively. We can provide fast neutron beam (20-70 MeV), and various ion beam such as p, alpha, and heavy ions up to Xe. We also develop a neutron imaging technique using fast neutron.

Researchers

Research Center for Accelerator and Radioisotope Science

Masatoshi Itoh

[Neutron scattering]

Neutron scattering study on macroscopic quantum phenomena

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特徴・独自性
  • In contrast to other scattering techniques, such as x-ray and electron diffractions, neutron scattering has the following advantages: 1) light atoms, such as H and Li, can be detected; 2) electron spins can be detected; 3) low energy excitations can be investigated. Using the neutron scattering technique, we search for macroscopic quantum phenomena in many-body electron systems, such as macroscopic singlet ground states in the quantum frustrated magnets and spin-fluctuation-mediated unconventional superconductors.
実用化イメージ

As noted above, neutron scattering can be used for investigating magnetic structure, spin dynamics, light atom positions in crystalline materials and their dynamics. Hence, this technique is very useful when those pieces of information are to be known.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Taku J Sato