"N" Keywords - 66 Result(s)

 N

[Nanophotonics]

Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine Microstructures

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特徴・独自性
  • In our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.
    • -Main research topics--
    MEMS tunable metamaterials for optical control.
  • Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers.
  • Surface-smoothing technology using surface self-diffusion.
  • Study of low loss silicon nanophotonic devices.
実用化イメージ

We aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed.
We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Yoshiaki Kanamori

[nanoporous material]

Development of Open Nanoporous Base and Half Metals, Metalloids and their Alloys

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特徴・独自性
  • Nanoporous metals have drawn considerable attention due to their highly functional properties. They are generally produced by selective dissolution of elements from a multicomponent alloy (known as the dealloying method). As this method is based on differences in the electrode potential of each element present in the alloy, and this potential is high for noble metals, porous structure can be obtained only for noble metals. Recently we have found a new, simple and easy dealloying method without using aqueous solution, which enable us to develop an open nanoporous non-oxidized metallic material even with base metals (such as Ti, Ni, Cr, Fe, Mo, etc), metalloids and their alloys.
実用化イメージ

This technique is very powerful for developing new functional electrodes, catalysts, filters as well for removing toxic metallic element from the surface of biomaterials containing the toxic element.

Researchers

Institute for Materials Research

Hidemi Kato

[Nanostructure]

Development of Nano-Interface Chemistry for Materials Sciences Using Surface Forces Measurement

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特徴・独自性
  • Our research aims at developing methods, including instrumentation, for characterizing surface (or interface) at the nano-meter level. Most of our research subjects are related to the surface forces measurement, which can directly monitor the interaction between two surfaces. We study phenomena occurring at the solid-liquid interface such as adsorption and structuring of liquids. We have developed the resonance shear measurement which is a sensitive method for evaluating properties of confined liquid for nano-rheology and tribology. Twin-path surface forces apparatus we developed enabled us to study wide variety of samples such as metals, ceramics and plastics.
実用化イメージ

These methods are applicable for characterizing lubricants, nano-materials, paints, sealants, and cosmetics. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

New Industry Creation Hatchery Center

Kazue Kurihara

Electronic properties of nanostructures and nanodevices

特徴・独自性
  • 1) We investigate interesting properties of nanostructures and develop materials and devices utilizing nanostructures.
  • 2) We have techniques and skills on low-noise electric measurements, cryogenics, nanofabrication, and data informatics. We are open to new collaborations.
実用化イメージ

Researchers

Advanced Institute for Materials Research

Tomohiro Otsuka

[Natural Crack]

Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation Techniques

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特徴・独自性
  • The emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding.
実用化イメージ

The method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for.

Researchers

Graduate School of Engineering

Noritaka Yusa

[natural language assessment ]

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

[natural language processing]

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

[Natural Product Chemistry]

Development of New Reactions Using Organocatalyst

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特徴・独自性
  • Organocatalyst is a synthetically useful catalyst in synthetic organic chemistry, because of the several merits. We have been investigating the development of new and efficient organocatalysts derived from proline. We have already reported the diphenylprolinol silyl ether, which is called as a Jorgensen-Hayashi catalyst, and siloxyproline, which is effective in the presence of water. We have also developed several practical asymmetric catalytic reactions based on the organocatalysts. We also applied these reactions to the total synthesis of natural products and drugs. We have already synthesized Tamiflu in one-pot reaction, and prostaglandin E1 methyl ester via three one-pot procedure.
実用化イメージ

Our newly developed reactions using organocatalysis can be widely used for synthesis of medicines, agrichemicals, and chemical products.

Researchers

Graduate School of Science

Yujiro Hayashi

[Nd-Fe-B]

Magnetic Materials (Permanent Magnets, High Frequency Materials, Microwave Absorbers)

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特徴・独自性
  • The objectives of my researches are the development of high performance magnets and improvement of their magnetic properties. I have already developed following high performance magnets, such as Nd-Fe-B magnets using didymium, Sm-Fe-N high coercive powders prepared by HDDR and Fe-Cr-Co magnets. Recently, I have studied about the reduction of Dy content in Nd-Fe-B magnets for the use of HEV and have succeeded to develop high coercive Dy-free Nd-Fe-B sintered magnets by decreasing the grain size. I have also developed new kinds of microwave absorbers for the use in the frequencies of GHz range using permanent magnetic materials or nanoparticles.
実用化イメージ

High performance magnetic materials can be used in many applications in automobile, home electronics, IT and medical industries. We hope to conduct collaborative researches with companies producing magnetic materials for the use in these applications, which aims to improve magnetic properties or to develop new magnetic materials.

Researchers

Graduate School of Engineering

Satoshi Sugimoto

[NDT]

Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation Techniques

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特徴・独自性
  • The emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding.
実用化イメージ

The method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for.

Researchers

Graduate School of Engineering

Noritaka Yusa

[network analyzer]

A Microwave-Based Non-Destructive Testing Method for the Long Range Inspection of Metallic Pipe

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特徴・独自性
  • We are developing a non-destructive testing method for the long range rapid inspection of metallic pipe using microwaves. The method propagates a microwave inside a pipe, and evaluates flaws appearing at the inner surface of the pipe on the basis of the reflection and transmission of the microwave. The method does not require scanning probes unlike conventional non-destructive methods, which enables one to inspect a pipe quite quickly. Our experimental validations have demonstrated the effectiveness of the method using a pipe as long as 30 m.
実用化イメージ

The NDT method proposed here is applicable when many pipes are inspected or conventional methods are not available due to pipe length and its configuration.

Researchers

Graduate School of Engineering

Hidetoshi Hashizume

[Network security]

Internet video streams have identities like fingerprints

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特徴・独自性
  • According to recent studies, each video that is streamed online has its own unique characteristic. The pattern of data that are sent through the network can vary from one encoding method to another and the change from scene to scene, which is a unique characteristic of each video. This research aims to identify video content in the network without looking at the data itself.
実用化イメージ

This research would be especially useful in preventing illegal distribution of television program such as illegal channel without violating user privacy. Another application would be to prevent confidential online meeting from leaking outside local enterprise network. In addition, it is also possible to investigate the circulation of a video content using method introduced by this work.

Researchers

Graduate School of Information Sciences

Nei Kato

[Network-on-CHip]

High-speed and low-power asynchronous Network-on-Chip system based multiple-valued current-mode logic

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特徴・独自性
  • Global intra-chip interconnection complexity not only limits the clock frequency, but causes clock-skew problems in synchronous system. Asynchronous control-based circuit design, where timing is managed locally, is one of the possible approaches to solve the above serious interconnection problem because the asynchronous design has many features which are low power dissipation, high speed and robustness. However, communication-steps overhead caused by handshaking much would generally affect the cycle time.
  • In our approach, a high-speed asynchronous data-transfer scheme is proposed based on multiple-valued encoding and current-mode circuits. The multiple-valued encoding enables to improve communication protocol essentially. Moreover, the current-mode circuits which has high-driving capability makes it possible to perform high-speed intra- and inter-chip network. By using this method, we expect that we can conduct effective collaborative research in high-speed and low-power communication LSIs such as a many-core LSI and a multi-module NoC.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Takahiro Hanyu

[Neural Network]

Brainmorphic Computing Hardware

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特徴・独自性
  • We will develop a brainmorphic computing hardware, which realizes the brain-specific functions such as conscious/sub-conscious process, self, selective attention, and so on, by directly using inherent physics and dynamics of constituent devices. The resulting hardware would be small, efficient, high-performance. Some examples include the chaotic neural network reservoir, optimization through high-dimensional complex dynamics, and neural network composed of spin-orbit torque nano-devices.
  • The resulting hardware is suitable for the edge AI which learns users’ personal behavior. Examples include watching service devices embedded in hearing aids or dental implants, which monitor and learn personal cardiac and brain-wave signals or saliva ingredients, to detect abnormal situations.
実用化イメージ

Edge AI devices, especially for peri-personal space), Time-series processing (prediction, recognition, and categorization), Online real-time learning.

Researchers

Research Institute of Electrical Communication

Yoshihiko Horio

[Neural precursors]

Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce neural precursor cells from human bone marrow stromal cells by introducing cells with Notch intracellular domain gene plasmid followed by culturing in neurosphere method. This induction system successfully generates neural precursors which were effective for stroke (J. Neuropathol. Exp. Neurol. , 2005; J Cereb Blood Flow Metab, 2009). They could be further developed into dopamine producing neurons by treating them with cytokines including GDNF (J. Clin. Invest, 2004). The efficiency and safety of induced dopamine neurons were confirmed by rat and monkey model of Parkinson's disease. Importantly, long-term survival of auto-transplanted induced dopamine neurons were verified by 11C-CFT PET scan (J. Clin. Invest, 2013).
実用化イメージ

We hope to collaborate with companies and research groups who are willing to utilize our system.

Researchers

Graduate School of Medicine

Mari Dezawa

[neural regeneration]

Development of a Novel Therapy for Amyotrophic Lateral Sclerosis (ALS) Using Hepatocyte Growth Factor (HGF)

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特徴・独自性
  • Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systematic motor neuron degeneration. Approximately 20% cases of familial ALS are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed transgenic rats that express a human SOD1 gene with two different ALS-linked mutations (G93A or H46R) showing progressive motor neuron degeneration and paralysis. The larger size of the rat ALS models as compared with existing mouse models will facilitate studies on neuroprotective and neuro-regenerative strategy involving manipulations of cerebrospinal fluid and spinal cord.
実用化イメージ

Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. Continuous intrathecal infusion of human recombinant HGF (hrHGF) attenuated loss of spinal motor neurons, astrocytosis, and microglial activation, leading to prolonged survival in the ALS rats. Safety and toxicology testing of the hrHGF protein in non-human primates should prompt further clinical trials in human ALS patients.

Researchers

Graduate School of Medicine

Masashi Aoki

Induction of Schwann cells from human mesenchymal stem cells and their application to spinal cord injury and demyelinating diseases

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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. Furthermore, marrow bank is available. Likewise, mesenchymal cells harvested from umbilical cord are also easily accessible from cord bank and are a good source of mesenchymal stem cells. We have established a system to induce functional Schwann cells (peripheral glia) from human bone marrow stromal cells and umbilical cord mesenchymal cells by treating cells with a series of reagents and cytokines. This induction system successfully generates Schwann cells with very high efficiency (~97%). They were confirmed to elicit neural regeneration in peripheral nerve damages and spinal cord injury (Eur, J. Neurosci, 2001; J. Neurosurg, 2004, J. Neuropathol. Exp. Neurol, 2005, Biochem Biophys Res Commun, 2007; Tissue Eng., 2011). The efficiency and safety of induced Schwann cells were demonstrated in monkey by 1 year follow up (Exp. Neurol., 2010). Importantly, induced cells not only elicited neural regeneration in both peripheral and central nervous system, but also contributed to functional recovery by restoring myelin and saltatory conduction. Therefore, these cells are expected to be effective to demyelinating diseases as well. We hope to collaborate with companies and research groups who are willing to utilize our system.
実用化イメージ

Researchers

Graduate School of Medicine

Mari Dezawa

[Neural stem cells]

Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce neural precursor cells from human bone marrow stromal cells by introducing cells with Notch intracellular domain gene plasmid followed by culturing in neurosphere method. This induction system successfully generates neural precursors which were effective for stroke (J. Neuropathol. Exp. Neurol. , 2005; J Cereb Blood Flow Metab, 2009). They could be further developed into dopamine producing neurons by treating them with cytokines including GDNF (J. Clin. Invest, 2004). The efficiency and safety of induced dopamine neurons were confirmed by rat and monkey model of Parkinson's disease. Importantly, long-term survival of auto-transplanted induced dopamine neurons were verified by 11C-CFT PET scan (J. Clin. Invest, 2013).
実用化イメージ

We hope to collaborate with companies and research groups who are willing to utilize our system.

Researchers

Graduate School of Medicine

Mari Dezawa

[Neurodegeneration]

Development of a Novel Therapy for Amyotrophic Lateral Sclerosis (ALS) Using Hepatocyte Growth Factor (HGF)

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特徴・独自性
  • Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systematic motor neuron degeneration. Approximately 20% cases of familial ALS are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed transgenic rats that express a human SOD1 gene with two different ALS-linked mutations (G93A or H46R) showing progressive motor neuron degeneration and paralysis. The larger size of the rat ALS models as compared with existing mouse models will facilitate studies on neuroprotective and neuro-regenerative strategy involving manipulations of cerebrospinal fluid and spinal cord.
実用化イメージ

Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. Continuous intrathecal infusion of human recombinant HGF (hrHGF) attenuated loss of spinal motor neurons, astrocytosis, and microglial activation, leading to prolonged survival in the ALS rats. Safety and toxicology testing of the hrHGF protein in non-human primates should prompt further clinical trials in human ALS patients.

Researchers

Graduate School of Medicine

Masashi Aoki

[Neuroimaging]

Brain Mechanism Realizing Human Mind

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特徴・独自性
  • I am investigating the brain mechanism of human mind. Specifically, my target is the internal schema that dissociate the self and other in the following three layers: physical, interpersonal, and social domains.
実用化イメージ

  • Improvement of the interface of the system
  • Clarifying the neuro-cognitive mechanism of the effect on the customer
  • New concept of the customer satisfaction

Researchers

Institute of Development, Aging and Cancer

Motoaki Sugiura