"O" Keywords - 57 Result(s)
O
[Obesity]
Development of New Drugs and Devices Regulating Inter-Organ Neural Network for Obesity TherapyFeaturesObesity induced the metabolic syndrome, which causes cardiovascular diseases. Obesity has now become a major health concern not only in developed countries but developing countries. However, diet and exercise are still major therapies. We discovered endogenous systems maintaining homeostasis of energy metabolism and revealed several neuronal networks among organs to be responsible for the regulation systems. Targeted Application(s)/IndustryOn the basis of these original discoveries, we are aiming at developing new drugs and/or building devices which regulate the inter-organ neuronal networks and hope to conduct collaborative research with a willing company for a practical application to obesity therapy. Center for Metabolic Diseases, Graduate School of Medicine
KATAGIRI Hideki, Professor
MD, PhD
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Analysis of Function of Functional Food Components Preventing AtherosclerosisFeaturesWe have much experience on basic studies including experimental animal research on improvement of lipid metabolism and prevention of obesity by functional food components. Causes of obesity and abnormality of lipid metabolism are complex, and measurement of enzyme activity and gene expression does not necessarily give us the precise information on mechanisms of improvement of lipid metabolism and prevention of obesity by food components. Targeted Application(s)/IndustryBased on our experience, we are prepared to provide academic consultations to companies interested in our research. In some situations, we can conduct effective collaborative research in this field. Food Function and Health, Graduate School of Agricultural Science
IKEDA Ikuo, Professor
Doctor of Agriculture
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[Object Tracking]
High-Speed Vision for Real-Time Motion AnalysisFeaturesWe are investigating high-speed vision systems that enable real-time image acquisition and visual processing at frame rates substantially higher than the standard video rate. Targeted Application(s)/IndustryHigh-speed vision systems are useful for fast measurement and control of dynamic systems in general. When combined with external facilities such as high-speed projectors or acceleration sensors, they enable further wider applications including fast 3D measurement or object identification. Graduate School of Information Sciences
KAGAMI Shingo, Associate Professor
Ph.D. (Eng.)
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[Occlusal accuracy]
High-Precision Capturing of 3-D Dental-Arch Shapes and Their Occlusal Relation and its Potential Implementation into CAD/CAM DentistryFeaturesIn spite of the long history of digital dentistry, the accuracy of the prosthetics fabricated with CAD/CAM systems is far from satisfactory. Jaw opening during taking impression elicits deformation of the mandible and the lower dental arch, and consequently causes the inaccuracy of occlusal relationship of the upper and lower dental arches on the CAD data. The method presented here utilizes the check-bite record at the maximum intercuspation to correct the relative positions among the teeth in the dental arches as well as between the arches. After this correction, the accuracy of the CAD data is satisfactory enough for the fabrication of the dental prosthetics which need no adjustment during their setting. Targeted Application(s)/IndustryThis method uses the newly-developed check-bite recording technique together with the conventional precious impression or optical impression techniques. It can easily be applied to the commercial CAD/CAM systems in the market. We hope to collaborate to the manufacturers of dental CAD/CAM systems to increase the accuracy of the systems. |
[octacalcium phosphate]
New Developments in Bone Regenerative TherapyFeaturesOctacalcium phosphate/collagen composites (OCP/Col: BonarcⓇ), a bone regenerative material commercialized in 2019, outperforms the bone regeneration of existing bone substitutes and is cost-effective and easy to use. Recently, we have demonstrated that the addition of teriparatide (TPTD: a parathyroid hormone for the treatment of osteoporosis) to OCP/Col, or improvements in the manufacturing process of OCP/Col, would expand their use for intractable bone defects and bone augmentation, which is difficult to treat. Targeted Application(s)/IndustryAs a medical devise of bone regenerative material, expansion of application in various bone defect (orthopedic surgery, neurosurgery, etc.) and overseas expansion would be expected. Furthermore, as a combination product based on OCP/Col would provide a therapeutic alternative for difficult bone defects or urgent surgery. Bone Regenerative Engineering Laboratory, Regenerative and Biomedical Engineering Division, Graduate School of Biomedical Engineering
KAMAKURA Shinji, Professor
Doctor of Dental Science
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Development of Novel Bone Substitute Biomaterials Showing Highly Osteoconductive PropertyFeaturesNovel bone substitute biomaterials should have a property not only to support cellular attachment on the material surfaces but also activate cellular function of osteoblasts that promote regeneration of bone tissue. Our laboratory successfully developed such materials composed of octacalcium phosphate (OCP) (Suzuki O et al. Dent Mater J 39:187, 2020. doi: 10.4012/dmj.2020-001), obtained by a restricted synthesis condition originally developed, with specific crystal characteristics, and various natural polymers, such as gelatin, collagen, alginate and hyaluronic acid. The materials consist from OCP and these polymers are capable of enhancing new bone formation concomitant with their own biodegradations. The concept to develop such materials is that (1) design of reaction of calcium phosphate ceramics and the synthesis; (2) design of material strength to meet the mechanical stress from living body; (3) selection of natural and synthetic polymer materials for the calcium phosphate ceramics. Targeted Application(s)/IndustryWe are prepared to provide academic consultations to companies interested in our research. Division of Craniofacial Function Engineering, Graduate School of Dentistry
SUZUKI Osamu, Professor
Doctor in Medical Sciencese
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[Octane number]
Identification of Ignition and Combustion Characteristics by a Micro Flow Rector with a Temperature GradientFeaturesWe have developed a methodology for identifying general ignition and combustion characteristics of gaseous and liquid fuels including bio and synthetic fuels. It enables identification of ignition and combustion characteristics of new fuels prior to application for practical combustion devices. The reactor system consists of a small diameter channel which has a temperature gradient from room temperature to the auto ignition temperature and thus reaction characteristics in different temperature levels can be easily investigated. Such a measurement had required research level skills and special devices such as rapid compression machine or shock tube which is costly in general, however, the micro flow reactor with temperature gradient enables reaction analysis easily. Targeted Application(s)/IndustryIt is expected to contribute to the designing of combustion devices, developments of new fuels, and chemical promoter and inhibitor. |
[ocular neovascular disease]
Regulation of AngiogenesisFeaturesAngiogenesis, i.e., the formation of new capillaries, takes place under pathophysiological conditions including cancers, ocular neovascular diseases and atherosclerosis. Anti-angiogenic drugs have been developed, and are now in clinical use. However, because of side effects due to the damage to vascular endothelial cells, the development of anti-angiogenic drugs with different modalities is anticipated. We have isolated vasohibin-1 (VASH1) as a novel angiogenesis inhibitor expressed by endothelial cells (ECs), and vasohibin-2 (VASH2) as its homologue having pro-angiogenic activity. Targeted Application(s)/IndustryWe are planning to develop strategies of VASH1 potentiation and VASH2 inhibition. For VASH1 potentiation, we are planning to use recombinant VASH1 protein or search low molecular weight substances having VASH1 like activity. For VASH2 inhibition, we are succeeded in the development of neutralizing anti-human VASH2 monoclonal antibody. |
[Okadaic Acid]
Development of a Novel Quantification Method for Diarrhetic Schell Fish PoisoningFeaturesWe have investigated isolation and structure determination of natural products and evaluated mode of their actions. We have especially focused on marine natural products causative for a food poisoning, diarrheic shellfish poisoning (DSP), which has spread worldwide and threatened regional fishery industry. Dinophysistoxin produced by the dinoflagellate Dinophysis spp. and okadaic acid, are thought to be responsible for DSP. Acute toxicity test using mice has been the primary method for detection of DSP in the fish market, though an alternative method to quantify DSP without sacrificing mice has been requested. We isolated OABP2, a novel okadaic acid binding protein, from the marine sponge Halichondria okadai and succeeded in expression of the recombinant OABP2 in E. coli, which eventually showed high affinity to the DSP toxins. Targeted Application(s)/IndustryWe are now working on visualization of OA by utilizing OABP2 in order to provide an easy and quick quantification method for DSP. |
[oligonucleotide therapeutics]
Creation of cancer cell specific oligonucleotide therapeuticsFeaturesFocusing our reseach interest mostly on the recognition and complexation behavior control of bioplymrs, such as DNA/RNA, proteines and so on. Another topics are reaction control based on molecular recognition phenomena in both ground and electronically excited states, we are pursuing mechanistic and synthetic studies on asymmetric photochemistry with supramolecular biopolymers as chiral reaction fields. Targeted Application(s)/IndustryInstitute of Multidisciplinary Research for Advanced Materials
WADA Takehiko, Professor
Doctor of Engineering
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[olihonucleotide]
Development of Intelligent Molecules for the Regulation of Gene Expression in CellsFeaturesThe artificial control of gene expression by synthetic oligodeoxynucleotides (ODNs) has been the subject of considerable interest. In particular, ODNs conjugated with a cross-linking agent have been expected to enhance the inhibitory effect. Recently, microRNAs (miRNA) endogenously expressed small regulatory non-coding RNAs, are recognized as playing a critical role in regulating gene expression and the great concerns have been raised about efficient antisense oligonucleotides against miRNAs. We have already demonstrated that ODNs bearing a 2-amino-6-vinylpurine (2-AVP) derivative exhibited efficient interstrand cross-linking to cytosine selectively. The unique structural features of AVP are to possess both the hydrogen bond donor-acceptor sites as recognition sites and the vinyl group as a reactive moiety in a single molecule. Recently, we have developed of the novel cross-linking agents, which are designed based on the unique structure of AVP. These derivatives can react to thymine at the complementary site with highly selective and efficient under neutral conditions. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. Targeted Application(s)/IndustryInstitute of Multidisciplinary Research for Advanced Materials
NAGATSUGI Fumi, Professor
PHD
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[Oncogenesis]
Elucidation of oncogenesis by Fbxw7FeaturesIn life science research field, it is noteworthy issue how information in genome is interpreted and is transferred to functional molecules. However, during these 10 years, we convinced that the amount of proteins, final functional molecules was regulated by not only by production but also by degradation. For examples, the amount of c-Myc, which promotes cell cycle and inhibits cell death, increase in many types of cancer by failure of protein degradation. Targeted Application(s)/Industry |
[online multi-user three-dimensional (3D) simulation]
OpenEnergySim: A Virtual World to Assess CO2 EmissionFeaturesIntelligent Transport System (ITS) strategies can significantly reduce CO2 emissions of vehicles. |
[opinion/information analysis]
Natural Language Processing for Semantic Analysis of Big DataFeaturesThis lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data. Targeted Application(s)/Industry(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc. |
[Optical]
Development of Electronic Instruments (Radio, Infrared, Optical, and Digital), Extensible Unit, and Embedded Software for SpacecraftFeaturesWe have performed the development of the radio wave receivers, radars, infrared & optical cameras / spectrometers, and digital instruments for various space projects. (Ex. KAGUYA [Lunar orbiter], BepiColombo [Mercury orbiter], Hisaki [EUV space telescope], Reimei [Small aurora-observatory], Arase [radiation belt], JUICE [Jupiter], the International Space Station [atmospheric camera IMAP], several sounding rockets and high-altitude balloon experiments.) Targeted Application(s)/IndustryBy historical reasons, the developments of these analog / digital circuits, FPGA, embedded software, extensible mechanics have mainly been with companies and engineers in Kanto and Chubu areas. We hope to find the counter companies / persons in Sendai / Miyagi / Tohoku areas. Planetary Plasma and Atmospheric Research Center
KASABA Yasumasa, Professor
PhD (Electronics)
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[optical biopsy]
Development of Optical Sysytems for Noninvasive Treatment and DiagnosisFeaturesOptical fiber-based endoscopic systems for non-invasive treatment and diagnosis are developed. The fiber transmits high-powered laser light for treatment and low-powered light for diagnosis. We develop treatment and diagnosis systems utilizing not only common glass-based optical fibers but hollow-optical fibers. Hollow optical fibers deliver high-powered infrared lasers and light with wide range of wavelength from ultraviolet and far infrared. Targeted Application(s)/IndustryOur potential collaborators will be medical device manufactures, as well as any electronic device, communication device, and measurement instrument manufactures considering new entry to the field. |
[optical communications systems]
R&D in Semiconductor Materials and their Device Applications Bringing System EvolutionsFeatures1. Development of Distributed Feedback (DFB) Laser Diodes (LD) widely used in optical communications systems realizing a highly information-based society. This LD increases the transmission capacity by 25,000 times per fiber which means the bit rate of 10Tb/s. Targeted Application(s)/IndustryDFB-LD: Fabrication of periodic structure with submicron scale, Epitaxial growth of semiconductor films on the substrate with fine structures, LD fabrication process, device evaluation, and device simulation New Industry Creation Hatchery Center
MATSUOKA Takashi, Professor
Doctor of Engineering
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[Optical Devices]
Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine MicrostructuresFeaturesIn our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.
Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers. Surface-smoothing technology using surface self-diffusion. Study of low loss silicon nanophotonic devices. Targeted Application(s)/IndustryWe aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed. |
[optical fibers]
Development of Optical Sysytems for Noninvasive Treatment and DiagnosisFeaturesOptical fiber-based endoscopic systems for non-invasive treatment and diagnosis are developed. The fiber transmits high-powered laser light for treatment and low-powered light for diagnosis. We develop treatment and diagnosis systems utilizing not only common glass-based optical fibers but hollow-optical fibers. Hollow optical fibers deliver high-powered infrared lasers and light with wide range of wavelength from ultraviolet and far infrared. Targeted Application(s)/IndustryOur potential collaborators will be medical device manufactures, as well as any electronic device, communication device, and measurement instrument manufactures considering new entry to the field. |
[Optical Filters]
Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine MicrostructuresFeaturesIn our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.
Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers. Surface-smoothing technology using surface self-diffusion. Study of low loss silicon nanophotonic devices. Targeted Application(s)/IndustryWe aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed. |