Tohoku University. Research Profiles

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"R" Keywords - 53 Result(s)

R

 R

[Radar]

Radar Remote Sensing

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We are developing new electromagnetic methodologies including radar and electromagnetic induction techniques, applying to natural resources survey and environmental monitoring. Currently, we are working for topics such as space borne and air borne microwave remote sensing sensors (SAR), Ground Penetrating Radar (GPR), Electromagnetic Induction methods (Metal detector) and their applications to subsurface sensing and humanitarian demining, and borehole radar for hydro geology. One of our sensors, ALIS which is a GPR system for land mine detection has been successfully operated in real mine field in Cambodia. These technologies using applied electromagnetics can be applied to other fields. We are seeking for industries which have interests in subsurface sensing and detection.

Targeted Application(s)/Industry

•Development and Application of Ground Penetrating Radar (GPR ) , EMI methods
(Ground water, soil moisture, landmine, explosive detection, archaeological survey, NDI)
Space borne and air borne Synthetic Aperture Radar (SAR) (Environmental monitoring, identification of vegetation, identification of targets)
Development and Application of Ground Based Synthetic Aperture Radar (GB-SAR) (Land slide monitoring, Tsunami, NDI)

Center for Northeast Asian Studies
SATO Motoyuki, Professor Doctor of Engineering

[radial polarization]

Development of Vector Beam and its Application to Nanoimaging

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Vector beams are very attractive because of their unique features such as small spot formation and strong longitudinal electric field near focus. We are developing a variety of generation methods of vector beams including Laguerre-Gaussian and Bessel-Gaussian beams and their higher order transverse modes. For instance, a smaller spot by approximately 30 % than that by a linearly polarized beam has been demonstrated and applied for nanoimaging.

Targeted Application(s)/Industry

Confocal scanning microscpy will benefit from vector beams as enhancement of spatial resolution. Otherwise, precision nano-processing will be possible. We are prepared to provide academic consultations to companies interested in our research.

Institute of Multidisciplinary Research for Advanced Materials
SATO Shunichi, Professor Doctor of Engineering

[Radiation Detector]

Development of Compound Semiconductor Radiation Detectors

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The main research subject of our group is developing material purification methods, crystal growth methods and detector fabrication technologies for compound semiconductor radiation detectors. Our group intensely studies a compound semiconductor, thallium bromide (TlBr), for fabrication of gamma-ray detectors for the advanced radiation applications. The attractive physical properties of TlBr lie in its high atomic number (Tl: 81, Br: 35), high density (7.56 g/cm3) and wide bandgap (2.68 eV). Due to the high atomic number and high density, TlBr exhibits high photon stopping power. The wide bandgap of TlBr permits the device low-noise operation at and above room temperatures.

Targeted Application(s)/Industry

Our group focuses on development of compound semiconductor radiation detectors for advanced radiation applications including ultra-high resolution PET systems, ultra-high resolution SPECT systems, photon counting CT systems and Compton cameras. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Department of Quantum Science and Energy Engineering, Graduate School of Engineering
HITOMI Keitaro, Associate Professor Doctor of Engineering

[radiation detectors]

Development of Novel Scintillator and Piezoelectric Crystals

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Our research target is mainly focused on the topic of development of novel scintillator crystals, piezoelectric crystals, growth technology, characterization and its device application.
We design and synthesize new materials from a view point of Crystal Chemistry, and investigate their structure and physical properties. We also study on photo-detector, as suitable photo-detector fully contribute to get maximum signal from scintillator. This activity is very important to realize practical application of our developed materials. Recently, piezoelectric material and high melting temperature alloy project is also started.

Targeted Application(s)/Industry

For the purpose of "real" contribution to human culture, we are always carrying out our research activity considering the industrial application. This point is unique feature of our attitude toward science.

Research Laboratory on Advanced Crystal Engineering, Institute for Materials Research
YOSHIKAWA Akira, Professor Doctor of Science

[Radio]

Development of Electronic Instruments (Radio, Infrared, Optical, and Digital), Extensible Unit, and Embedded Software for Spacecraft

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We have performed the development of the radio wave receivers, radars, infrared & optical cameras / spectrometers, and digital instruments for various space projects. (Ex. KAGUYA [Lunar orbiter], BepiColombo [Mercury orbiter], Hisaki [EUV space telescope], Reimei [Small aurora-observatory], Arase [radiation belt], JUICE [Jupiter], the International Space Station [atmospheric camera IMAP], several sounding rockets and high-altitude balloon experiments.)

Targeted Application(s)/Industry

By historical reasons, the developments of these analog / digital circuits, FPGA, embedded software, extensible mechanics have mainly been with companies and engineers in Kanto and Chubu areas. We hope to find the counter companies / persons in Sendai / Miyagi / Tohoku areas.

Planetary Plasma and Atmospheric Research Center
KASABA Yasumasa, Professor PhD (Electronics)

[Radiophamaceutical Chemistry]

Molecular Imaging from Basic Research to Clinical Application

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Molecular Imaging and its Application to Drug Development: Positron emission tomography (PET) comprises the administration of carbon-11- or fluorine-18-labeled tracers to human subjects in order to describe the concentration-time profile in body tissues targeted for treatment. As PET involves the administration of only microgram amounts of unlabeled drug, the potential risk to human subjects is very limited. Consequently, required preclinical safety testing is reduced as compared to conventional human studies.

Targeted Application(s)/Industry

PET molecular imaging studies are gaining increasing importance in clinical drug research, as they have the potential to shorten time-lines and cut costs along the critical path of drug development. We have developed several PET tracers for molecular imaging such as amyloid imaging and central nervous system drug research at Tohoku University, Japan. We will present the recent progress and strategy of "PET molecular imaging" in order to accelerate drug development.

Department of Pharmacology, Graduate School of Medicine, and Cyclotron and Radioisotope Center
YANAI Kazuhiko, Professor MD., PhD

[Rapid and low cost spacecraft development]

Design and Development of 50 kg-class Micro Satellites

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We design and develop micro satellites in a format of 50 cm cubic size and 50 kg mass. We have developed the first and second micro satellites of Tohoku University, named “RISING” and “RISING-2”, launched by using JAXA’s H-IIA rocket vehicle in January 2009 and May 2014, respectively. Both satellites are operated from our ground station in the university. Particularly, RISING-2 has succeeded in capturing high precision color images of the Earth's surface at a spatial resolution of 5m, the highest in the world among 50kg-class satellites. Now the third micro satellite for international science mission is under the development. In addition, we are active in nano satellite development. The first nano-sat “RAIKO” in a 10 by 10 by 20 cm format was launched from the International Space Station in 2012. More nano-sats are under the development.

Targeted Application(s)/Industry

We would like to make innovation in space business by introducing a new paradigm for rapid and low cost development of space systems for various missions of remote sensing, earth observation, and space exploration. We have rich experience in the development of spacecraft bus systems, onboard avionics systems and mission instruments. Collaborations with technology and business partners are welcome.

Department of Aerospace Engineering, Graduate School of Engineering
YOSHIDA Kazuya, Professor Doctor of Engineering

[rare metals]

Magnetic Materials (Permanent Magnets, High Frequency Materials, Microwave Absorbers)

Features

The objectives of my researches are the development of high performance magnets and improvement of their magnetic properties. I have already developed following high performance magnets, such as Nd-Fe-B magnets using didymium, Sm-Fe-N high coercive powders prepared by HDDR and Fe-Cr-Co magnets. Recently, I have studied about the reduction of Dy content in Nd-Fe-B magnets for the use of HEV and have succeeded to develop high coercive Dy-free Nd-Fe-B sintered magnets by decreasing the grain size. I have also developed new kinds of microwave absorbers for the use in the frequencies of GHz range using permanent magnetic materials or nanoparticles.

Targeted Application(s)/Industry

High performance magnetic materials can be used in many applications in automobile, home electronics, IT and medical industries. We hope to conduct collaborative researches with companies producing magnetic materials for the use in these applications, which aims to improve magnetic properties or to develop new magnetic materials.

Department of Materials Science, Graduate School of Engineering
SUGIMOTO Satoshi, Professor Doctor of Engineering

[real-time]

Clinical Applications of Motion Capture System for Living Body

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We have developed a wireless motion capture system for living body that could non-invasively measure various biological movements without any contact. By utilizing the LC resonant magnetic marker due to the latest magnetic engineering technology, we have achieved a magnetic wireless system which could be used even in a shielded space such as oral cavity by applying a magnetic field from outside the body. By using the infrared reflective markers of small and light, we have also succeeded in developing an optical system capable of synchronous real-time measurement at up to 50 locations at 250 hertz.

Targeted Application(s)/Industry

This new system can three dimensionally analyze various biological movements and can be applied to such diagnostic and medical equipment that requires a motion analysis non-invasively without any contact. It is possible to specialize this system to suit the required conditions, so I would like to joint research with companies and organizations that want to take advantage of this system.

Liaison Center for Innovative Dentistry, Graduate School of Dentistry
KANETAKA Hiroyasu, Professor D. D. S., Ph. D

[real-time analysis]

Measurement-Integrated Simulation to Analyze Complex Flows

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In order to obtain huge fluid information of real flows we are developing a new flow analysis methodology "measurement-integrated simulation" by integrating experimental measurement and computer simulation. Complex real flows are accurately reproduced by the effect of a feedback signal to compensate the difference between the measurement and calculation. This can be appliedto wide variety of complex flow problems, for example, real-time visualization of blood flows for medical diagnosis, flow analysis around automobile body, real-time monitoring of flow in a complex piping in a nuclear power plant.
We are prepared to provide academic consultations to companies interested in our research.

Institute of Fluid Science
HAYASE Toshiyuki, Professor Doctor of Engineering

[recombinant protein design]

Peptide and Protein Designs for Unexplored Fileds

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I am proposing methodologies to design recombinant peptides and proteins with appropriate structures and functions in the medicinal, environmental, material, and nanotechnological fields, with molecular evolutional and domain shuffling engineering. At present, we have constructed the methodologies for efficient renaturation of functional proteins from inclusion bodies expressed in bacteria, generation of peptides and proteins with the function of biomineralization, generation of peptides and proteins with affinity for inorganic materials to spontaneously make linkages between various nanomaterials, and high enhancement of cellulolytic enzyme activity induced by nanoclustering design on nanomaterials.

Targeted Application(s)/Industry

We hope the business partners in the in the medicinal, environmental, material, and nanotechnological fields would be interested in my approaches and we could conduct effective collaboration research with them.

Graduate School of Engineering
UMETSU mitsuo, Professor Doctor of Engineering

[reconfigurable circuit]

PVT-Variation-Aware VLSI System Based on Nonvolatile-Device/MOS-Hybrid Circuitry

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Nonvolatile devices, which can remain stored data without power supply, are generally used for ROM (Read-Only Memory) to store boot programs (the information to start up the computer and the basic instructions that operate it) in computers. One attractive feature is that it does not consume any static power while it remains stored data. ‘Nonvolatile logic' is a novel logic style that a nonvolatile device is used for not only a nonvolatile storage element such as ROM but also a logic-circuit element which is the basic component of a CPU and an entire system. By using the nonvolatile devices as storage elements of circuit-configuration information, we can realize a process-variation- aware logic circuit with small hardware overhead.

Targeted Application(s)/Industry

The proposed technique is effective for implementing high-performance and highly-reliable LSI fabricated with cutting-edge process technology. We expect we can conduct effective collaborative research in highly reliable VLSI-systems fields.

Research Institute of Electrical Communication
HANYU Takahiro, Professor PhD of Engineering

[recrystallization]

Room temperature bonding using thin metal films (Atomic Diffusion Bonding)

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Atomic diffusion bonding of two flat wafers with thin metal films is a promising process to achieve wafer bonding at room temperature. High surface energies of metal films and a large atomic diffusion coefficient at the grain boundaries and film surfaces enable bonding at room temperature without unusually high loading pressure. This technique, which enables bonding of any mirror-polished wafer, is gaining wider use for fabricating optical and electrical devices. Moreover, bonding of mirror polished metals and polymer sheets can be achieved, which further extends the application of this bonding technique.

Targeted Application(s)/Industry

Optical, power and electrical devices, MEMS, bonding of polymer sheets, metals, and ceramics for precision mechanical equipments.

Frontier Research Institute for Interdisciplinary Sciences
SHIMATSU Takehito, Professor Doctor of Engineering

[Recycle]

Monomer-Recycle System of Biodegradable Plastics by Industrial Fungal Fermentation and Application of Fungal Biosurfactant Proteins to Nanoparticles for Medical Use

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In Japan, solid-phase fungal fermentation systems using the industrial fungus Aspergillus oryzae have been extensively used for producing fermented foods such as soy sauce and sake; the annual production volume of the products is over one million tons. The efficient enzymatic hydrolyzing systems are expected to be applicable to biological recycling of biodegradable plastics. We found that A. oryzae can effectively degrade polybutylene succinate-coadipate (PBSA) by the combination with an esterase (cutinase) CutL1 and novel surfactant proteins, RolA and HsbA that are attached to the surface of PBSA and then recruit CutL1. The recruitment of Cutl1 by the surfactants stimulated PBSA degradation.

Targeted Application(s)/Industry

The fungal biosurfactant protein is applicable to industrial recycling of biodegradable plastics and to production of immune-response free nano-particles for medical use.

Graduate School of Agricultural Science
ABE Keietsu, Professor Doctor of Agriculture

[Recycling]

Development of Recycling Technology for High-Water Content Sludge by Using Fiber Materials

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The recycling rate of construction muds and sludge is very low because the water content of these muds is very high and direct reuse of them is very difficult. Therefore, a new recycling technology for high-water content sludge has been developed in this laboratory. This technology is called "Fiber-Cement-Stabilized Soil Method", and it uses fiber materials and cement. The main feature of this method is to mix the fiber materials with the sludge, and the fiber materials included in the soil produce several geotechnical merits.

Targeted Application(s)/Industry

The modified soils produced by this method can be used as ground materials for reinforced embankment of the river bank and soil structures because they have several features such as high failure strength, high failure strain high durability for drying and wetting and high dynamic strength.

Graduate School of Environmental Studies
TAKAHASHI Hiroshi, Professor Doctor of Engineering

[Reflective Display]

Development of the high-quality and low-power display system for ultra-realistic communications

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Recently, with a spread of high definition video streaming services and ubiquitous network, development of high-quality, ultra-realistic and low-power display systems has been demanded. We have been studying physical properties of liquid crystal materials, precise control technique of polarization, high performance liquid crystal display (LCD) devices and its application to the advanced display systems for the realization of new media such as electric paper display and digital signage display, and low-energy society. We established a polarization control technology which realizes a precise control of polarization with liquid crystal materials. By using this world-leading technology, we have been studying the control of the surface alignment of liquid crystal molecules and developed a wide-viewing angle and fast switching liquid crystal display, ultra-high definition field-sequential-color display (Fig. 1), ultra-low power reflective full-color display (Fig. 2) and large-size high-quality display system.
We are also studying the ultra-realistic display systems such as a spatial 3D display and a multiple directional viewing display based on the precise light control technique as a next generation interactive communication technologies (Fig.3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
ISHINABE Takahiro, Associate Professor Doctor of Engineering

[Regeneration]

Extracorporeal Shock Wave Therapy as a New, Non-Invasive Angiogenic Therapy

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Extracorporeal shock wave (SW) therapy was introduced clinically more than 20 years ago to fragment kidney stones, which has markedly improved the treatment of urolithiasis. We found that a low-energy SW (about 10% of the energy density that is used for urolithiasis) effectively increases the expression of vascular endothelial growth factor (VEGF) in cultured endothelial cells. Based on this in vitro study, we have initiated in vivo studies and have demonstrated that extracorporeal cardiac SW therapy with a low-energy SW up-regulates the expression of VEGF, induces neovascularization, and improves myocardial ischemia in a porcine model of chronic myocardial ischemia, without any adverse effects in vivo. On the basis of promising results in animal studies, we performed a series of clinical studies in patients with severe coronary artery disease without indication of PCI or CABG, including, firstly, an open trial followed by a placebo-controlled, double-blind study. In both studies, our extracorporeal cardiac SW therapy improved symptoms, exercise capacity, and myocardial perfusion in patients with severe coronary artery disease. Importantly, no procedural complications or adverse effects were noted. The SW therapy was also effective in ameliorating left ventricular remodeling after acute myocardial infarction (MI) in pigs and in enhancing angiogenesis in hind-limb ischemia in rabbits. Based on these animal studies, we are also conducting clinical studies in patients with acute MI and in those with peripheral arterial disease. Thus, our extracorporeal cardiac SW therapy is an effective, safe, and non-invasive angiogenic approach in cardiovascular medicine and its indication could be extended to a variety of ischemic diseases in the near future.

Targeted Application(s)/Industry

The treatment for severe angina pectoris was approved as a highly advanced medical treatment by Ministry of Health, Labour and Welfare, Japan in 2010.
The low-energy SW therapy would be applicable to a wide range of diseases. Your inquiries about the collaborative research are always welcome.

Department of Cardiovascular Medicine, Graduate School of Medicine
SHIMOKAWA Hiroaki, Professor MD, PhD

[regenerative medicine]

New Developments in Bone Regenerative Therapy

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Octacalcium phosphate/collagen composites (OCP/Col: Bonarc), a bone regenerative material commercialized in 2019, outperforms the bone regeneration of existing bone substitutes and is cost-effective and easy to use. Recently, we have demonstrated that the addition of teriparatide (TPTD: a parathyroid hormone for the treatment of osteoporosis) to OCP/Col, or improvements in the manufacturing process of OCP/Col, would expand their use for intractable bone defects and bone augmentation, which is difficult to treat.

Targeted Application(s)/Industry

As a medical devise of bone regenerative material, expansion of application in various bone defect (orthopedic surgery, neurosurgery, etc.) and overseas expansion would be expected. Furthermore, as a combination product based on OCP/Col would provide a therapeutic alternative for difficult bone defects or urgent surgery.

Bone Regenerative Engineering Laboratory, Regenerative and Biomedical Engineering Division, Graduate School of Biomedical Engineering
KAMAKURA Shinji, Professor Doctor of Dental Science

DIFFERENTIATION INDUCING METHOD ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

Features

The present invention relates to a technique for differentiating iPS cells into target differentiated cells while suppressing tumorigenesis in the iPS cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.

Targeted Application(s)/Industry

Graduate School of Dentistry Division of Molecular and Regenerative Prosthodontics
EGUSA Hiroshi, Professor D.D.S., Ph.D.