"C" Keywords - 127 Result(s)

 C

[C3H/lpr mouse]

Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen Disease

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特徴・独自性
  • Eleven strains of recombinant inbred (RI) mice derived from MRL/lpr and C3H/lpr mice were established. This RI is the only one in the world that randomly develops lesions such as nephritis, arthritis, sialadenitis, vasculitis, and production of autoantibodies in each strain. The genomes of the two strains of mice are randomly held in homozygous condition, and the phenotypes of each strain and the effects of administered drugs could be compared based on their genotype maps. It is possible to identify the regions of gene loci involved in the phenotype and drug sensitivity.
実用化イメージ

Development of diagnostic and therapeutic agents for autoimmune diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, and industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.

Researchers

Graduate School of Biomedical Engineering

Tetsuya Kodama

[CAD/CAM]

High-Precision Capturing of 3-D Dental-Arch Shapes and Their Occlusal Relation and its Potential Implementation into CAD/CAM Dentistry

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特徴・独自性
  • In spite of the long history of digital dentistry, the accuracy of the prosthetics fabricated with CAD/CAM systems is far from satisfactory. Jaw opening during taking impression elicits deformation of the mandible and the lower dental arch, and consequently causes the inaccuracy of occlusal relationship of the upper and lower dental arches on the CAD data. The method presented here utilizes the check-bite record at the maximum intercuspation to correct the relative positions among the teeth in the dental arches as well as between the arches. After this correction, the accuracy of the CAD data is satisfactory enough for the fabrication of the dental prosthetics which need no adjustment during their setting.
実用化イメージ

This method uses the newly-developed check-bite recording technique together with the conventional precious impression or optical impression techniques. It can easily be applied to the commercial CAD/CAM systems in the market. We hope to collaborate to the manufacturers of dental CAD/CAM systems to increase the accuracy of the systems.

Researchers

Graduate School of Dentistry

Yoshinori Hattori

[Calibration]

Advanced Vision System with Less Calibration

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特徴・独自性
  • The difficulties of introducing robot systems in production line are maintenance of environment and teaching of robot motion. Environ recognition and motion teaching using vision system will greatly improve the difficulties. However, calibration of vision-robot system is tedious and troublesome. Feedback control using vision sensor information will allow robustness against environment and teach by showing. This technique is called visual servo.
実用化イメージ

Visual servo will allow flexible camera setting, calibration-less system setting, and easy teaching.

Researchers

Graduate School of Information Sciences

Koichi Hashimoto

[Cancer]

Creation of cancer cell specific oligonucleotide therapeutics

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特徴・独自性
  • Focusing our reseach interest mostly on the recognition and complexation behavior control of bioplymrs, such as DNA/RNA, proteines and so on. Another topics are reaction control based on molecular recognition phenomena in both ground and electronically excited states, we are pursuing mechanistic and synthetic studies on asymmetric photochemistry with supramolecular biopolymers as chiral reaction fields.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Takehiko Wada

[carbon]

newExtraction of cellulose nanofibers (CNFs) from sea pineapples' shells and application for energy materials

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概要

The sea pineapple is the only animal that produces cellulose, and its shells, excluding the edible parts, are treated as industrial waste. By removing proteins and other components from the sea squirt shells and fibrillating them, cellulose nanofibers (CNFs) can be extracted. We have focused on the fact that CNFs derived from sea squirt shells have a higher degree of crystallinity and greater mechanical strength compared to those from wood, and we are exploring various applications of this material. Furthermore, since the material transforms into high-quality carbon upon calcination, we successfully developed "nano-blood carbon catalysts" by mixing it with dried blood powder and calcining the mixture. These catalysts are being applied in fuel cells, water electrolysis, and metal-air batteries.

従来技術との比較

CNFs derived from sea pineapple's shells have a higher degree of crystallinity compared to those from wood and provide longer fibers, resulting in high strength. When calcined, they transform into high-performance carbon.

特徴・独自性
  • We are the only research laboratory that has consistently developed a process for the simple and large-scale purification of CNFs derived from sea pineapple's shells, along with the creation of film materials that leverage their unique properties (mechanical, engineering, surface science, electrical, and thermal characteristics), as well as the development of carbonized materials.
実用化イメージ

We offer materials derived from sea pineapples' shell CNFs, as well as their carbonized products and catalysts. Please feel free to consult us regarding material supply, carbonization processes, or the utilization of catalysts.

Researchers

Advanced Institute for Materials Research

Hiroshi Yabu

[Carbon dioxide]

Development of catalytic reaction system for direct synthesis from CO2 and diols

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特徴・独自性
  • We found an effective catalyst system composed of CeO2 and 2-cyanopyridine for direct and catalytic polycarbonate formation reaction from CO2 and diols. CeO2 acted as an activator for CO2 and diols, and 2-cyanopyridine shifted the equilibrium in favor of the product side by hydration of 2-cyanopyridine, promoting the reaction. Green polycarbonates can be synthesized by combination of the catalyst system with a technique of diol syntheses from biomass.
実用化イメージ

This catalyst system is effective for direct transformation of CO2, contributing to the effective utilization and emission reduction of CO2. Combination of the catalyst system with a concentration technique of CO2 will bring about much advantage.

Researchers

Graduate School of Engineering

Keiichi Tomishige

[carbon fiber]

Peptide formation under high P and T conditions: new carbon fibers

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特徴・独自性
  • Peptides are formed through the enzymatic actions in living organisms, but difficulty exists to form peptide by non-enzymatic actions. Here we report the success of peptide formation under anhydrous, high P and T conditions. We were successful to form 11-mer of glycine and 5-mer of alanine. They are important constituents of spider silk, which is a candidate of next generation of carbon fibers. Therefore, our techniques have potentials to apply making new carbon fibers without biotechnology.
実用化イメージ

Researchers

Graduate School of Science

Takeshi Kakegawa

[Carbon nanotube]

Development of High Performance Carbon Nanotube-Alumina Composite

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特徴・独自性
  • One of the important challenges in the development of carbon nanotubes (CNTs) reinforced ceramic composites is uniform dispersion of CNTs in the matrix. The mechanical properties of CNT/ceramics composites have been limited to date due to the formation of CNT agglomerates in the composite. We have successfully produced CNT/alumina composites with world top class strength and toughness, by employing a newly developed CNTs dispersion technique based on a flocculation method. The processing method developed in this study enables us to prepare high performance CNT materials using a pressureless sintering method.
実用化イメージ

The possible applications of the CNT/alumina composites developed in this study include tribological materials (ball bearing), biomaterials (artificial hip joint), micro-actuator materials utilizing electrostrictive effects, electromagnetic wave absorber, particularly in the frequency range of several GHz and several ten GHz.

Researchers

New Industry Creation Hatchery Center

Toshiyuki Hashida

[carbon neutral]

Theory and practice of energy design to drive decarbonization

概要

An indispensable function for decarbonized driving is energy data analysis, an energy car navigation system with both high spatial and temporal resolution. Higher spatial resolution facilitates the recharging and discharging of electric cars and inter-regional energy exchange. With the addition of up-to-the-minute energy data with high temporal resolution, it is possible to rationally and optimally combine the fluctuating output of renewable energy with the consumers. Data analysis, system design, and operation will lead to a carbon-neutral society.

従来技術との比較

Japan's first regional energy supply and demand database has been developed, allowing for detailed design of sustainable and resilient regional energy infrastructure layout and operation based on analysis of the current energy status of cities, towns, and villages nationwide.

特徴・独自性
  • Research experience as a Fulbright Scholar in the U.S. and familiarity with examples of social implementation in Europe.
  • Data-driven innovation research approach based on a vast regional energy supply and demand database.
  • Emphasis on regional fieldwork as a social entrepreneur solving social issues.
実用化イメージ

Putting Theory into Practice. Helping to build sustainable energy systems for new community development. Including the background of the local community, listening to the opinions of the residents, and guiding them to discussions that are relevant to today's issues. Thinking globally and acting within the community.

Researchers

Graduate School of Engineering

Toshihiko Nakata

[Carbon neutral, design]

Carbon Neutral Design Theory

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特徴・独自性
  • Assist in designing communities to be carbon neutral by 2050. Provide an internationally compatible regional energy supply and demand database under development to support current analysis and rational scenario design for the future. Support the design of regional energy systems based on up-to-date analysis of the renewable energy potential of each region, including hydrogen energy and LCA assessments, to meet regional and industry needs, and provide methods for performance analysis and value assessment.
実用化イメージ

Those in charge of the implementation plan for a decarbonized society and the carbon neutral plan, which is an extension of the basic environmental plan, at local governments.
Business leaders who provide new energy services, including new local power companies.

Researchers

Graduate School of Engineering

Toshihiko Nakata

[carbondioxide]

Role of Volatiles on Petit-Spot Volcanoes

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特徴・独自性
  • The new kind of volcanoes, petit-spot, are located off NE Japan and Chile. They erupt at a submarine portion to be far from tectonic plate boundaries (e.g., mid-oceanic ridges and volcanic arcs) of the usual sites of volcanoes, earthquakes, and related geologic activity. The magmas have extremely high carbon dioxide and possibly originate from the base of tectonic plate.
実用化イメージ

The magma is squeezed upward and erupts in deep submarine environment wherever the tectonic plate flexes and fractures in the world. Collaborating work with business community would be required in order to search the submarine volcanoes and their related mines.

Researchers

Center for Northeast Asian Studies

Naoto Hirano

[Cardiac Contraction]

Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries

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特徴・独自性
  • Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured by CT, MRI, SPECT, or conventional ultrasound. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions (US patent 5840028), we have detected the minute mechanical response (velocity component) to the propagation of the action potential in the human heart or to detect the propagation of the vibrations along the heart wall caused by the valve closure (Fig. 2).
  • By applying the same procedure to the human arteries, the regional change in wall thickness caused during one cardiac cycle can be measured with high spatial resolution (Fig. 1). From the measurement, the regional elasticity of tissue surrounding atherosclerotic plaque can be determined. By comparing the pathological findings with the distribution of elasticity, elasticity of lipid and that of fibrous tissue were determined. Thus, each point inside the plaque is classified into lipid or fibrous tissue using transcutaneous ultrasound (Fig. 3).
実用化イメージ

This novel method offers potential as a diagnostic technique for detection of plaque vulnerability with high spatial resolution.
We are prepared to provide academic consultations to companies interested in our research.

Researchers

Graduate School of Engineering

Hiroshi Kanai

[Casting cavity]

Advanced die casting process computing with solidification phenomena

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特徴・独自性
  • Die casting is a method of mass-producing high-precision castings in a short time by filling the mold with molten metal at high pressure and high speed. Since solidification is completed quickly under high pressure, various defects peculiar to die casting occur. Significantly, the casting cavity has a high incidence in die casting, and it is a factor that hinders the quality. Therefore, a numerical approach to the die casting process is expected to prevent these problems, and the information obtained from the numerical analysis is expected to be reflected in the casting plan to reduce the number of prototypes, the lead time to product development, and the cost. In this study, a multiphase flow analysis with solidification phenomena of molten aluminum inside mold was conducted for a high-pressure die casting process of the throttle body.
実用化イメージ

Automotive industry, Automotive suppliers, Foundry industry

Researchers

Institute of Fluid Science

Jun Ishimoto

[catalyst]

Development of Open Nanoporous Base and Half Metals, Metalloids and their Alloys

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特徴・独自性
  • Nanoporous metals have drawn considerable attention due to their highly functional properties. They are generally produced by selective dissolution of elements from a multicomponent alloy (known as the dealloying method). As this method is based on differences in the electrode potential of each element present in the alloy, and this potential is high for noble metals, porous structure can be obtained only for noble metals. Recently we have found a new, simple and easy dealloying method without using aqueous solution, which enable us to develop an open nanoporous non-oxidized metallic material even with base metals (such as Ti, Ni, Cr, Fe, Mo, etc), metalloids and their alloys.
実用化イメージ

This technique is very powerful for developing new functional electrodes, catalysts, filters as well for removing toxic metallic element from the surface of biomaterials containing the toxic element.

Researchers

Institute for Materials Research

Hidemi Kato

Development of catalytic reaction system for direct synthesis from CO2 and diols

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特徴・独自性
  • We found an effective catalyst system composed of CeO2 and 2-cyanopyridine for direct and catalytic polycarbonate formation reaction from CO2 and diols. CeO2 acted as an activator for CO2 and diols, and 2-cyanopyridine shifted the equilibrium in favor of the product side by hydration of 2-cyanopyridine, promoting the reaction. Green polycarbonates can be synthesized by combination of the catalyst system with a technique of diol syntheses from biomass.
実用化イメージ

This catalyst system is effective for direct transformation of CO2, contributing to the effective utilization and emission reduction of CO2. Combination of the catalyst system with a concentration technique of CO2 will bring about much advantage.

Researchers

Graduate School of Engineering

Keiichi Tomishige

newExtraction of cellulose nanofibers (CNFs) from sea pineapples' shells and application for energy materials

NEXT
PREV
概要

The sea pineapple is the only animal that produces cellulose, and its shells, excluding the edible parts, are treated as industrial waste. By removing proteins and other components from the sea squirt shells and fibrillating them, cellulose nanofibers (CNFs) can be extracted. We have focused on the fact that CNFs derived from sea squirt shells have a higher degree of crystallinity and greater mechanical strength compared to those from wood, and we are exploring various applications of this material. Furthermore, since the material transforms into high-quality carbon upon calcination, we successfully developed "nano-blood carbon catalysts" by mixing it with dried blood powder and calcining the mixture. These catalysts are being applied in fuel cells, water electrolysis, and metal-air batteries.

従来技術との比較

CNFs derived from sea pineapple's shells have a higher degree of crystallinity compared to those from wood and provide longer fibers, resulting in high strength. When calcined, they transform into high-performance carbon.

特徴・独自性
  • We are the only research laboratory that has consistently developed a process for the simple and large-scale purification of CNFs derived from sea pineapple's shells, along with the creation of film materials that leverage their unique properties (mechanical, engineering, surface science, electrical, and thermal characteristics), as well as the development of carbonized materials.
実用化イメージ

We offer materials derived from sea pineapples' shell CNFs, as well as their carbonized products and catalysts. Please feel free to consult us regarding material supply, carbonization processes, or the utilization of catalysts.

Researchers

Advanced Institute for Materials Research

Hiroshi Yabu

[Catalysts]

Advanced Molecular Transformations by Organocatalysts

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特徴・独自性
  • The development of organic molecules which function as a catalyst has been extensively investigated to achieve selective and efficient transformation of organic molecules. Brønsted acids and bases are commonly employed as the catalyst in synthetic organic chemistry. To aim at their functionalization, axially chiral phosphoric acids and axially chiral guanidine bases have been developed as chiral Brønsted acid and base catalysts, respectively. A variety of optically active compounds has been synthesized through the development of highly stereoselective reactions using these catalysts.
実用化イメージ

The development of chiral Brønsted acid and base catalysts has been accomplished as recoverable and reusable organocatalysts and highly stereoselective molecular transformations have been established using these catalysts. The present methodology is applicable to process chemistry in preparing medicines and relevant compounds on the basis of the selective and efficient molecular transformations thus developed with reduction of the waste material.

Researchers

Graduate School of Science

Masahiro Terada

[Catheter]

Minimally Invasive Medical Devices and Healthcare Devices Using Micro/Nano Machining Technology

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特徴・独自性
  • Medical devices and healthcare devices which have several functions with small size have been developed using precise micromachining technology and MEMS (Microelectromechanical systems) technology. More precise and safe diagnostics and therapy, as well as novel diagnostics and treatment can be realized by developing high-functionalized endoscopes and catheters and developing novel medical devices. Healthcare without restriction of location and time is aimed by developing thin, light and high-functionalized new healthcare devices.
実用化イメージ

Besides of basic research, we are working in cooperation with clinicians and medical device companies for practical use. We founded a university-launched venture company for bridge-building between university and company and collaborative researches have been performed.

Researchers

Graduate School of Biomedical Engineering

Yoichi Haga

[Cavitation]

Cavitation Peening

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特徴・独自性
  • Surface modification method to improve fatigue strength has been developed using cavitation impacts, which are normally causes severe damage in hydraulic machineries. The method was called "cavitation peening". In order to make clear the mechanism, a load controlled plate bending fatigue test machine was developed. It was proved by using the test machine that the threshold level of stress intensity factor was improved about 1.9 times by cavitation peening. The mitigation of hydrogen embrittlement by cavitation peening was also improved.
実用化イメージ

The cavitation peening can apply to component of automobile and forging die. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Hitoshi Soyama

Development of a Numerical Prediction System for Sliding Part Wear and Seizure Occurrence Portions

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概要

Focusing on the lubricant film flow with phase change between the engine piston pin and connecting rod small end, we developed a new multiphase fluid-structure coupled analysis method that takes into account elastic deformation of the structure and flow path changes and developed a simulation prediction method for tribological properties under high load conditions. The simulation prediction method for tribological properties under high load conditions has been created. As a result, we succeeded in simulation prediction of the wear/seizure generating areas in sliding parts. We discovered that the peculiar deformation behavior of the components is the cause of wear/seizure.

従来技術との比較

It has been thought that computational prediction is impossible to verify the wear and seizure locations in fluid lubrication. Still, this study succeeded in the simulation prediction of wear and seizure locations in sliding parts.

特徴・独自性
  • Numerical prediction of the wear and seizure locations in the sliding parts of engine piston pins was successfully performed.
  • The bow-like deformation of the piston pin was identified as the cause of mechanical contact and seizure at the connecting rod edge.
  • A three-dimensional multiphase fluid-structure coupled analysis method has been successfully developed, considering the piston pin's elastic deformation and connecting rod and thin-film cavitation1 lubrication with unsteady flow path changes.
実用化イメージ

This research method applies to automotive engines and all sliding component elements using fluid lubrication. It contributes to damage prediction and the development of safety guidelines for transportation and industrial machinery components, enabling the optimal design of components.

Researchers

Institute of Fluid Science

Jun Ishimoto