Research Profiles

JP

"C" Keywords - 126 Result(s)

C
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 C

[Current-mode logic]

High-speed and low-power asynchronous Network-on-Chip system based multiple-valued current-mode logic

 
 
 
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特徴・独自性
  • Global intra-chip interconnection complexity not only limits the clock frequency, but causes clock-skew problems in synchronous system. Asynchronous control-based circuit design, where timing is managed locally, is one of the possible approaches to solve the above serious interconnection problem because the asynchronous design has many features which are low power dissipation, high speed and robustness. However, communication-steps overhead caused by handshaking much would generally affect the cycle time.
  • In our approach, a high-speed asynchronous data-transfer scheme is proposed based on multiple-valued encoding and current-mode circuits. The multiple-valued encoding enables to improve communication protocol essentially. Moreover, the current-mode circuits which has high-driving capability makes it possible to perform high-speed intra- and inter-chip network. By using this method, we expect that we can conduct effective collaborative research in high-speed and low-power communication LSIs such as a many-core LSI and a multi-module NoC.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Takahiro Hanyu

[Custom Implants]

Bioimplants that are as close to natural teeth as possible

概要

By applying nanoscale surface modification to individually designed 3D-printed titanium implants based on CT data, a biomimetic microenvironment is recreated, enabling regeneration of periodontal ligament-like tissue through host stem cell induction. This provides a novel treatment approach without cell transplantation for cases where existing implants are difficult to adapt.

従来技術との比較

Conventional implant treatment assumes direct bonding with bone, thus disregarding the regeneration of periodontal tissues such as the periodontal ligament. Furthermore, some patients avoid treatment due to concerns about bone-cutting surgery and multiple invasive procedures. This technology utilizes a nano-surface to induce stem cells, forming periodontal tissues similar to natural teeth. This enables the restoration of natural occlusal sensation through a single minimally invasive procedure.

特徴・独自性
  • Custom-designed for each patient's root morphology, it reproduces natural force transmission and chewing sensation. Furthermore, by utilizing nanostructures to control cell adhesion and differentiation, it enables periodontal tissue reconstruction without the need for cell transplantation or regenerative factor administration.
実用化イメージ

In the future, we aim to collaborate with implant manufacturers to advance mass-production prototyping and quality evaluation, targeting practical application as a medical device. We also seek partnerships with companies and management talent who can jointly undertake strategic planning and clinical deployment for commercialization.

Researchers

Graduate School of Biomedical Engineering

Masahiro Yamada

[Custom-Made Medical Devices]

Bioimplants that are as close to natural teeth as possible

概要

By applying nanoscale surface modification to individually designed 3D-printed titanium implants based on CT data, a biomimetic microenvironment is recreated, enabling regeneration of periodontal ligament-like tissue through host stem cell induction. This provides a novel treatment approach without cell transplantation for cases where existing implants are difficult to adapt.

従来技術との比較

Conventional implant treatment assumes direct bonding with bone, thus disregarding the regeneration of periodontal tissues such as the periodontal ligament. Furthermore, some patients avoid treatment due to concerns about bone-cutting surgery and multiple invasive procedures. This technology utilizes a nano-surface to induce stem cells, forming periodontal tissues similar to natural teeth. This enables the restoration of natural occlusal sensation through a single minimally invasive procedure.

特徴・独自性
  • Custom-designed for each patient's root morphology, it reproduces natural force transmission and chewing sensation. Furthermore, by utilizing nanostructures to control cell adhesion and differentiation, it enables periodontal tissue reconstruction without the need for cell transplantation or regenerative factor administration.
実用化イメージ

In the future, we aim to collaborate with implant manufacturers to advance mass-production prototyping and quality evaluation, targeting practical application as a medical device. We also seek partnerships with companies and management talent who can jointly undertake strategic planning and clinical deployment for commercialization.

Researchers

Graduate School of Biomedical Engineering

Masahiro Yamada

[Cutting]

Joule Heat Welding of Ultrathin Metallic Wires and its Application for Producing Functionality

 
 
 
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特徴・独自性
  • For producing a new functionality from metallic micro and nano matarials, the welding and cutting technologies for small scale materials utilizing Joule heat has been developed (Fig. 1). A constant direct current is supplied to the system, where the free ends of two metallic wires are contacted, and the ends are successfully welded together in self-completed manner. This technology is also useful for manipulating a small scale materials.
実用化イメージ

Joule heat welding technology enables us to produce the functional elements on the electrode chips, e.g., a free-standing micro-ring and very-thin thermoelectric element (Fig. 2). Moreover, we have developed the technique for characterizing the physical properties of small scale materials (Fig. 3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Hironori Tohmyoh

[cyclodepsipeptides]

Synthesis of Biologically Active Cyclodepsipeptide Natural Products

 
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特徴・独自性
  • Cyclodepsipeptide natural products include optically active hydroxy acids as well as various unnatural amino acids and exhibit a variety of biological activity depending on the peptide sequence, chirality, and selection of the hydroxy acids. Structure-activity relationships of a synthetic library of natural products could give us significant information of not only biologically important moieties but also intact positions in the biologically active small molecules. On the basis of the former information, more potent compounds and/or peptide mimetics can be designed. The latter information can also be important for making a molecular probe that is used for exploration of a target molecule.
実用化イメージ

We study for combinatorial synthesis of natural product analogues using solid-phase.

Researchers

Graduate School of Pharmaceutical Sciences

Takayuki Doi

[Cyclotron]

Development of the cyclotron accelerator and its application

 
 
 
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特徴・独自性
  • We develop technology of the cyclotron accelerator and its application as follows. 1)Ion source (particularly heavy ion source), 2)design of ion optics, 3)device control system for the cyclotron, 4)RF system, 5)detectors for charged particles, gamma ray, and neutron, 6) radiation test by ion and neutron beam.
実用化イメージ

We have beam lines dedicated to the neutron irradiation and the ion irradiation, respectively. We can provide fast neutron beam (20-70 MeV), and various ion beam such as p, alpha, and heavy ions up to Xe. We also develop a neutron imaging technique using fast neutron.

Researchers

Research Center for Accelerator and Radioisotope Science

Masatoshi Itoh

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