Research Profiles

JP

"P" Keywords - 104 Result(s)

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 P

[peripheral nerve disorders]

Induction of Schwann cells from human mesenchymal stem cells and their application to spinal cord injury and demyelinating diseases

 
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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. Furthermore, marrow bank is available. Likewise, mesenchymal cells harvested from umbilical cord are also easily accessible from cord bank and are a good source of mesenchymal stem cells. We have established a system to induce functional Schwann cells (peripheral glia) from human bone marrow stromal cells and umbilical cord mesenchymal cells by treating cells with a series of reagents and cytokines. This induction system successfully generates Schwann cells with very high efficiency (~97%). They were confirmed to elicit neural regeneration in peripheral nerve damages and spinal cord injury (Eur, J. Neurosci, 2001; J. Neurosurg, 2004, J. Neuropathol. Exp. Neurol, 2005, Biochem Biophys Res Commun, 2007; Tissue Eng., 2011). The efficiency and safety of induced Schwann cells were demonstrated in monkey by 1 year follow up (Exp. Neurol., 2010). Importantly, induced cells not only elicited neural regeneration in both peripheral and central nervous system, but also contributed to functional recovery by restoring myelin and saltatory conduction. Therefore, these cells are expected to be effective to demyelinating diseases as well. We hope to collaborate with companies and research groups who are willing to utilize our system.
実用化イメージ

Researchers

Graduate School of Medicine

Mari Dezawa

[permeability]

Magnetic Materials (Permanent Magnets, High Frequency Materials, Microwave Absorbers)

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特徴・独自性
  • The objectives of my researches are the development of high performance magnets and improvement of their magnetic properties. I have already developed following high performance magnets, such as Nd-Fe-B magnets using didymium, Sm-Fe-N high coercive powders prepared by HDDR and Fe-Cr-Co magnets. Recently, I have studied about the reduction of Dy content in Nd-Fe-B magnets for the use of HEV and have succeeded to develop high coercive Dy-free Nd-Fe-B sintered magnets by decreasing the grain size. I have also developed new kinds of microwave absorbers for the use in the frequencies of GHz range using permanent magnetic materials or nanoparticles.
実用化イメージ

High performance magnetic materials can be used in many applications in automobile, home electronics, IT and medical industries. We hope to conduct collaborative researches with companies producing magnetic materials for the use in these applications, which aims to improve magnetic properties or to develop new magnetic materials.

Researchers

Graduate School of Engineering

Satoshi Sugimoto

[Personal Information Trade]

Blockchain-based Approachs for High Secure P2P-type Decentralized Cloud Storage and Practical Smart Contract for Trading Personal Data

 
 
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特徴・独自性
  • We are developing a decentralized P2P (Peer to Peer) type cloud storage that realizes innovative level of security by use of surplus storages of P2P nodes with the Blockchain technology. The developed storage can avoid the risk of large-scale information leakage of stored data due to the weakness of the central server. By using our cryptographic currency for rewards and usage fees in the storage, fair storage usage of all users can also be achieved.
  • In addition, We are developing a unique smart contract technology for practical decentralized trading of personal data among an unspecified number of users.
実用化イメージ

We hope to conduct collaborative researches with companies developing Bitcoin 2.0 type application (e.g. smart contract, Fintech) based on the Blockchain technology, the Internet of Things (IoT) technology, Medical Database for practical use.

Researchers

Center for Data-driven Science and Artificial Intelligence

Masao Sakai

[personal mobility]

Coexistence of humans and mobile robots

 
 
 
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特徴・独自性
  • A variety of new mobilities coexisting with humans, such as service robots, self-driving cars, and personal mobility, are expected to be deployed. In this laboratory, we are studying technologies for the safe and smooth coexistence of these various mobile vehicles with humans.
  • In particular, we are approaching the problem from the aspect of predicting the movement of humans by considering their characteristics such as visual attention.
実用化イメージ

The targeted application is service robots, personal mobility, self-driving cars, and other mobile vehicles that will be expected to coexist with humans, as well as the design of transportation environments for these vehicles to safely coexist with humans.

Researchers

Graduate School of Engineering

Yusuke Tamura

[pest management]

Lethal effects of blue light on insects

 
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特徴・独自性
  • We revealed the strong lethal effect of short-wavelength visible light (blue light: 400–500 nm) on insects. That is, we found that blue light irradiation by using a common light-emitting diode (LED) can kill the eggs, larvae, pupae, and adults of various orders of insects. Our findings will provide clean and safe pest-control technique as well as important information on the hazards of exposure to visible light.
実用化イメージ

Researchers

Graduate School of Agricultural Science

Masatoshi Hori

[Pesticide]

Study on Molecular Mechanism for Plant Immune System

 
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特徴・独自性
  • Plants have immune system against pathogen infection. In our research group, isolation of disease resistance genes, analysis of signal transduction pathways for disease resistance and characterization of defense-related proteins have been performed so far. In addition, we produced transgenic plants expressing green fluorescent protein under the control of defense-inducible promoter, which will be useful to visualize the induction of defense system.
実用化イメージ

Our knowledge obtained from the study on the mechanism(s) for plant immune system and the reporter transgenic plants will be available for screening chemical compounds activating plant immune system (so-called "plant activator").

Researchers

Graduate School of Agricultural Science

Hideki Takahashi

[PET]

Chemical Recycling of Problematic Polymeric Wastes

 
 
 
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特徴・独自性
  • The Yoshioka Laboratory works on the recycling of various polymers by thermal and wet processes. Plastics such as poly(ethylene terephthalate) (PET), polyvinyl chloride (PVC), and high impact polystyrene (HIPS) cause serious problems during their recycling for the recycling process and the environment. However, these materials can also be seen as a resource for new materials. The decarboxylation of PET results in high yields of benzene that can be used as a chemical feedstock. Another important feature is the dehalogenation of flame retarded plastics and PVC. Dechlorinated plastic waste can be an important source for hydrocarbons, which can be used as fuels and chemical feedstock. The chemical modification of PVC offers the possibility of new materials with new properties. Modified PVC can be used as antibacterial material or as a material with ion exchange properties. The removal of brominated flame retardants from HIPS leads to higher recovery rates of styrene during thermal processing. When a wet process is used, the resulting flame retardant free HIPS can be reused.
実用化イメージ

We are eager to help companies to overcome their problems during recycling and recovery, and provide solutions for the treatment of waste materials.

Researchers

Graduate School of Environmental Studies

Toshiaki Yoshioka

Development of Compound Semiconductor Radiation Detectors

 
 
 
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特徴・独自性
  • The main research subject of our group is developing material purification methods, crystal growth methods and detector fabrication technologies for compound semiconductor radiation detectors. Our group intensely studies a compound semiconductor, thallium bromide (TlBr), for fabrication of gamma-ray detectors for the advanced radiation applications. The attractive physical properties of TlBr lie in its high atomic number (Tl: 81, Br: 35), high density (7.56 g/cm3) and wide bandgap (2.68 eV). Due to the high atomic number and high density, TlBr exhibits high photon stopping power. The wide bandgap of TlBr permits the device low-noise operation at and above room temperatures.
実用化イメージ

Our group focuses on development of compound semiconductor radiation detectors for advanced radiation applications including ultra-high resolution PET systems, ultra-high resolution SPECT systems, photon counting CT systems and Compton cameras. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Keitaro Hitomi

Radiological Medical Infomatics

 
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特徴・独自性
  • PET and SPECT have very high sensitivity to detect molecule by means of radiation detection, and are considered to be excellent tools for molecular imaging. We are studying and developing data analysis techniques for PET and SPECT data. Using our approaches, we can analyze data in quantitative manner, and obtain physiological functions in living organism.
実用化イメージ

Pharmaceutical companies who are interested in using PET to evaluate efficacy of new drug. Companies which are related to medical informatics, medical equipments.

Researchers

Cyclotron and Radioisotope Center

Hiroshi Watabe

Functional and Molecular Imaging with Positron Emission Tomography (PET)

 
 
 
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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Cyclotron and Radioisotope Center

Manabu Tashiro

[PF-NOTE]

Changing Corporate In-Service Training

 
 
 
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特徴・独自性
  • We have developed a system named PF-NOTE that the system uses video cameras, clickers and a computer to bookmark an audience's clicker feedback into simultaneously recorded video. We are also doing research for creating effective education or learning programs by using the developed system. The system has been mainly used for reflective learning, and we have found that this system is effective in various situations for both teacher and learners, such as practice teaching for early career teachers, developing presentation skills, and developing discussion skills.
実用化イメージ

We offer PF-NOTE system(s) and education/learning program(s) to companies that are of particular interest with respect to communication skills training, passing skills to the younger generation of employees, observation skill training and job interview training.

Researchers

Graduate School of Education

Taira Nakajima

[Pharmacokinetics]

Radiological Medical Infomatics

 
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特徴・独自性
  • PET and SPECT have very high sensitivity to detect molecule by means of radiation detection, and are considered to be excellent tools for molecular imaging. We are studying and developing data analysis techniques for PET and SPECT data. Using our approaches, we can analyze data in quantitative manner, and obtain physiological functions in living organism.
実用化イメージ

Pharmaceutical companies who are interested in using PET to evaluate efficacy of new drug. Companies which are related to medical informatics, medical equipments.

Researchers

Cyclotron and Radioisotope Center

Hiroshi Watabe

[pharmacological effects]

Functional and Molecular Imaging with Positron Emission Tomography (PET)

 
 
 
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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Cyclotron and Radioisotope Center

Manabu Tashiro

[Phase]

X-Ray Phase Imaging for High-Sensitive Non-Destructive Testing

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特徴・独自性
  • Conventional X-ray imaging methods that rely on X-ray attenuation cannot generate clear contrast in the observation of low-density materials such as polymers consisting of low-Z elements. However, the sensitivity to the materials can be improved drastically by X-ray phase imaging that detects X-ray refraction caused by the materials. X-ray Talbot or Talbot-Lau interferometry consisting of X-ray transmission gratings is now constructed in laboratories for X-ray phase imaging. X-ray phase tomography is also realized, enabling high-sensitive three-dimensional observation.
  • X-ray phase imaging can be utilized for X-ray non-destructive testing of industrial products and baggage that cannot be checked conventionally.
実用化イメージ

We aim at appending a phase-contrast mode to micro-CT apparatuses and developing screening apparatuses in production lines.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Atsushi Momose

[Phase change]

Advanced die casting process computing with solidification phenomena

 
 
 
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特徴・独自性
  • Die casting is a method of mass-producing high-precision castings in a short time by filling the mold with molten metal at high pressure and high speed. Since solidification is completed quickly under high pressure, various defects peculiar to die casting occur. Significantly, the casting cavity has a high incidence in die casting, and it is a factor that hinders the quality. Therefore, a numerical approach to the die casting process is expected to prevent these problems, and the information obtained from the numerical analysis is expected to be reflected in the casting plan to reduce the number of prototypes, the lead time to product development, and the cost. In this study, a multiphase flow analysis with solidification phenomena of molten aluminum inside mold was conducted for a high-pressure die casting process of the throttle body.
実用化イメージ

Automotive industry, Automotive suppliers, Foundry industry

Researchers

Institute of Fluid Science

Jun Ishimoto

[phase change memory]

Study on Phase Change Materials for PCRAM Application

 
 
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特徴・独自性
  • Phase change random access memory (PCRAM) has attracted attention as next-generation non-volatile memories. A conventional PCM is Ge-Sb-Te which shows a fast crystallization speed and an excellent reversibility of phase transition. However, Ge-Sb-Te has a low crystallization temperature of about 150 ºC and a high melting temperature of over 600 ºC , which limits data retention and causes high power consumption, respectively.
  • We have developed a new phase change materials with high crystallization temperature and low melting point such as Ge-Cu-Te etc, which have high potential as PCRAM materials with high thermal stability and low power consumption (Fig.1,2).
実用化イメージ

Our materials are developed for PCRAM, DVD recording materials etc. We hope the collaboration research with companies which are interested in our developed phase change materials.

Researchers

Graduate School of Engineering

Yuji Suto

[PHD]

Development of PHD-Targeted Drug for Ischemic Injury

 
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特徴・独自性
  • All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
  • We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.
実用化イメージ

Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Researchers

Graduate School of Medicine

Toshio Miyata

[Philosophy of Technology]

Philosophy of Science and Technology, Science and Technology Studies (STS)

 
 
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特徴・独自性
  • My research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users.
実用化イメージ

I hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction.

Researchers

Graduate School of Arts and Letters

Kiyotaka Naoe

[photoacoustic imaging]

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

 
 
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特徴・独自性
  • "Features"
  • High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
  • "Targeted Application(s)/Industry"
  • High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.
実用化イメージ

Researchers

Graduate School of Biomedical Engineering

Yoshifumi Saijo

[Photocatalysis]

Photo-Induced Characteristics of TiO2 Prepared by Anodic Oxidation

 
 
 
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特徴・独自性
  • Ti anodizing technique has been offered for coloring the surface of Ti, and its mechanism is understood by light interference varied with the oxide thickness. A characteristic of this study is to control the crystallinity of the oxide, and its originality is to provide photo-induced characteristics to Ti and its alloys by controlling the electrochemical conditions differed from that of coloration technology. This study is aimed for controlling the surface of Ti by using a simple and easy, inexpensive technique and to fabricate high functional titanium materials.
実用化イメージ

Related to practical applications, it is considered as a use for environmental purification such as deodorization and water purification, biomaterial and antibacterial and structural titanium.

Researchers

Institute for Materials Research

Naoya Masahashi

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