Research Profiles

JP

"P" Keywords - 104 Result(s)

P
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 P

[P2P (Peer to Peer)]

Blockchain-based Approachs for High Secure P2P-type Decentralized Cloud Storage and Practical Smart Contract for Trading Personal Data

 
 
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特徴・独自性
  • We are developing a decentralized P2P (Peer to Peer) type cloud storage that realizes innovative level of security by use of surplus storages of P2P nodes with the Blockchain technology. The developed storage can avoid the risk of large-scale information leakage of stored data due to the weakness of the central server. By using our cryptographic currency for rewards and usage fees in the storage, fair storage usage of all users can also be achieved.
  • In addition, We are developing a unique smart contract technology for practical decentralized trading of personal data among an unspecified number of users.
実用化イメージ

We hope to conduct collaborative researches with companies developing Bitcoin 2.0 type application (e.g. smart contract, Fintech) based on the Blockchain technology, the Internet of Things (IoT) technology, Medical Database for practical use.

Researchers

Center for Data-driven Science and Artificial Intelligence

Masao Sakai

[packaging]

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

 
 
 
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概要

We offer shared facility for the development of semiconductor prototypes equipped with 4-inch, 6-inch and some 8-inch wafer fabrication tools available on an hourly basis. Know-how accumulated at Tohoku University is available, and staff provide maximum support for prototyping. The service is performed at the 1,200 m2 Super Clean Room on the second floor of the Junichi Nishizawa Memorial Research Centre at Tohoku University. For information on equipment and fees, see our website.

従来技術との比較

More than 10 experienced technical staff assist customer's usages. Standard process conditions for each process, such as etching and deposition, are provided. allowing customers to start prototyping immediately. Various materials other than silicon can also be supported.

特徴・独自性
  • We support the development of devices and semiconductor materials such as MEMS, optical elements and RF components.
  • Technical consultation on devices and processes before and during prototyping is also available.
  • A
  • 'Prototype lab' for device packaging is also available.
  • The museums where you can learn about the history of semiconductors, measuring instruments and sensors are open.
  • As part of Technology Co-creation for Semiconductor of Tohoku University, we promote R&D of semiconductors and the development of human resources.
  • On-demand semiconductor human resource development programs for students and engineers are available.
  • As a member of the MEXT's Advanced Research Infrastructure for Materials (ARIM) program, we are involved in sharing facility and data.
実用化イメージ

More than 310 companies have used our shared facility since its launch in 2010, not only from device manufacturers such as MEMS, but also from manufacturers of materials, mechanical components and equipment. To date, we have successfully supported the commercialization of about 10 devices.

Researchers

Micro System Integration Center

Kentaro Totsu

[pain]

The Novel Ultrasound Irradiation Device

 
 
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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[Pancreatic beta cells]

Development of devices regulating inter-organ neural network for diabetes therapy

 
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特徴・独自性
  • Diabetes induces several complications, including retinopathy and nephropathy. In patients with type 1 diabetes as well as those with type 2 diabetes, pancreatic beta cells have reportedly decreased. Therefore, regeneration therapy of pancreatic beta cells may be very effective for major populations of diabetic patients. We discovered a neuronal network, from the liver, which selectively elicits pancreatic beta cell proliferation (Science 2008, Fig.). In a murine model with insulin-deficient diabetes, stimulation of this network improved diabetes. Thus, building devices which regulate the inter-organ neuronal network may lead to “regenerative therapy” for diabetes which regenerates pancreatic beta cells in the pancreas using patients’ own cells and patients’ own systems. We hope to conduct collaborative research with a willing company for a practical application of this technology.
実用化イメージ

Researchers

Graduate School of Medicine

Hideki Katagiri

[Pannus]

Development of McH-lpr/lpr-RA1 mouse, a study model that spontaneously develops severe autoimmune arthritis, vasculitis, and sialadenitis

 
 
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特徴・独自性
  • McH/lpr-RA1 mice are recombinant congenic mice descended from MRL/lpr and C3H/lpr mice and develop arthritis, vasculitis, and sialadenitis with high frequency and severity, with severe pannus formation similar to rheumatoid arthritis, polyarteritis nodosa, and Sjogren's syndrome. On the other hand, McH/lpr-RA1 mice do not develop systemic lymphadenopathy and severe nephritis as seen in MRL/lpr mice, so they are easy to breed and maintain and can be used for long-term drug administration experiments.
実用化イメージ

Development of diagnostic and therapeutic agents for collagen diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, etc. Industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.

Researchers

Graduate School of Biomedical Engineering

Tetsuya KODAMA

[parameter-variation compensation]

PVT-Variation-Aware VLSI System Based on Nonvolatile-Device/MOS-Hybrid Circuitry

 
 
 
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特徴・独自性
  • Nonvolatile devices, which can remain stored data without power supply, are generally used for ROM (Read-Only Memory) to store boot programs (the information to start up the computer and the basic instructions that operate it) in computers. One attractive feature is that it does not consume any static power while it remains stored data. ‘Nonvolatile logic' is a novel logic style that a nonvolatile device is used for not only a nonvolatile storage element such as ROM but also a logic-circuit element which is the basic component of a CPU and an entire system. By using the nonvolatile devices as storage elements of circuit-configuration information, we can realize a process-variation- aware logic circuit with small hardware overhead.
実用化イメージ

The proposed technique is effective for implementing high-performance and highly-reliable LSI fabricated with cutting-edge process technology. We expect we can conduct effective collaborative research in highly reliable VLSI-systems fields.

Researchers

Research Institute of Electrical Communication

Takahiro Hanyu

[Parkinson's disease, stroke]

Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

 
 
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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce neural precursor cells from human bone marrow stromal cells by introducing cells with Notch intracellular domain gene plasmid followed by culturing in neurosphere method. This induction system successfully generates neural precursors which were effective for stroke (J. Neuropathol. Exp. Neurol. , 2005; J Cereb Blood Flow Metab, 2009). They could be further developed into dopamine producing neurons by treating them with cytokines including GDNF (J. Clin. Invest, 2004). The efficiency and safety of induced dopamine neurons were confirmed by rat and monkey model of Parkinson's disease. Importantly, long-term survival of auto-transplanted induced dopamine neurons were verified by 11C-CFT PET scan (J. Clin. Invest, 2013).
実用化イメージ

We hope to collaborate with companies and research groups who are willing to utilize our system.

Researchers

Graduate School of Medicine

Mari Dezawa

[passing skills to younger generation]

Changing Corporate In-Service Training

 
 
 
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特徴・独自性
  • We have developed a system named PF-NOTE that the system uses video cameras, clickers and a computer to bookmark an audience's clicker feedback into simultaneously recorded video. We are also doing research for creating effective education or learning programs by using the developed system. The system has been mainly used for reflective learning, and we have found that this system is effective in various situations for both teacher and learners, such as practice teaching for early career teachers, developing presentation skills, and developing discussion skills.
実用化イメージ

We offer PF-NOTE system(s) and education/learning program(s) to companies that are of particular interest with respect to communication skills training, passing skills to the younger generation of employees, observation skill training and job interview training.

Researchers

Graduate School of Education

Taira Nakajima

[Passive ]

Development of Passive Millimeter-wave Imaging Device for Practical Applications

 
 
 
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特徴・独自性
  • Millimeter wave (MM-wave) which is one of the electromagnetic wave transparent the clothes, the fire and the wall etc. and all natural materials including objects in clothes always radiate the electromagnetic wave as the thermal noise. Using these characteristics of MM-wave, imaging of concealed objects in clothes can be accomplished in a noninvasive and noncontact manner. This technique is called Passive Millimeter Wave (PMMW) Imaging technique and we have developed a PMMW imaging device for security applications.
  • The wave length of MM-wave frequency range is from 1 mm to 10 mm and the spatial resolution of images in MM-wave range is low compared with sub-millimeter (terahertz) range or Infra-Red range, however, higher transmittance through clothes can be obtained compared with higher frequency range. Furthermore, low noise amplifier (LNA) exists which could be the advantage of MM-wave compared with higher frequency ranges.
  • Now the device was developed for the purpose of keeping safe and secure aircrafts and ships etc., we hope to conduct collaborative research with a willing company for a practical application of this technology in industrial fields such as the fire rescue, the police equipment and the medical devices.
実用化イメージ

Researchers

Graduate School of Engineering

Hiroyasu Sato

[Patents]

Indentation modulus 8.4 GPa! Resin replica mold more solid than polyimide

概要

Light curing high strength resin mold
https://www.t-technoarch.co.jp/data/anken_en/T11-053.pdf

特徴・独自性
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Masaru Nakagawa

[Pattern matching]

Internet video streams have identities like fingerprints

 
 
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特徴・独自性
  • According to recent studies, each video that is streamed online has its own unique characteristic. The pattern of data that are sent through the network can vary from one encoding method to another and the change from scene to scene, which is a unique characteristic of each video. This research aims to identify video content in the network without looking at the data itself.
実用化イメージ

This research would be especially useful in preventing illegal distribution of television program such as illegal channel without violating user privacy. Another application would be to prevent confidential online meeting from leaking outside local enterprise network. In addition, it is also possible to investigate the circulation of a video content using method introduced by this work.

Researchers

Graduate School of Information Sciences

Nei Kato

[Pattern recognition receptors]

Development of Immunobiotic Evaluation System for Functional Feeds as a Livestock Animal Model

 
 
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特徴・独自性
  • Pattern recognition receptor (PRR) family plays an important role in the defense through recognition of pathogen-associated molecular patterns or microorganisms-associated molecular patterns (PAMPs/MAMPs).
  • Some functional feed materials are thought to regulate intestinal immunity by contact and stimulation of epithelial cells and immunocompetent cells via PRRs in the gastrointestinal tract and induction of cytokine production. In this "new world" of feed immunology, however, much remains unknown about the underlying mechanisms of intestinal immunity because of lack of appropriate intestinal immunoassay system for livestock animals.
  • We have advanced application of originally established porcine and bovine intestinal epitheliocytes (PIE, BIE) cell lines (see photo) for evaluation of immunobiotics and immunogenics exerting anti-inflammatory responses both in PIE cell monolayer and co-culture system with porcine peyer's patch immune cells as a peyer's patch culture model (see illustration).
実用化イメージ

This evaluation system may also contribute to elucidate immunoregulatory mechanism of immunobiotics and immunogenics mediated by pattern recognition receptors essential to future development of not only immunobiotic feeds but also vaccines using immunobiotics to prevent specific diseases. This can benefit mankind by offering immunobiotic feeds as a safer alternative to conventional antibiotic drug therapy.

Researchers

Graduate School of Agricultural Science

Haruki Kitazawa

[pedestrian prediction]

Coexistence of humans and mobile robots

 
 
 
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特徴・独自性
  • A variety of new mobilities coexisting with humans, such as service robots, self-driving cars, and personal mobility, are expected to be deployed. In this laboratory, we are studying technologies for the safe and smooth coexistence of these various mobile vehicles with humans.
  • In particular, we are approaching the problem from the aspect of predicting the movement of humans by considering their characteristics such as visual attention.
実用化イメージ

The targeted application is service robots, personal mobility, self-driving cars, and other mobile vehicles that will be expected to coexist with humans, as well as the design of transportation environments for these vehicles to safely coexist with humans.

Researchers

Graduate School of Engineering

Yusuke Tamura

[Peening]

Cavitation Peening

 
 
 
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特徴・独自性
  • Surface modification method to improve fatigue strength has been developed using cavitation impacts, which are normally causes severe damage in hydraulic machineries. The method was called "cavitation peening". In order to make clear the mechanism, a load controlled plate bending fatigue test machine was developed. It was proved by using the test machine that the threshold level of stress intensity factor was improved about 1.9 times by cavitation peening. The mitigation of hydrogen embrittlement by cavitation peening was also improved.
実用化イメージ

The cavitation peening can apply to component of automobile and forging die. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Hitoshi Soyama

[Peltier effect]

Development of Potential Thermoelectric Materials

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特徴・独自性
  • We have been exploring novel thermoelectric materials. Functions of a solid substance primarily depend on the electronic structure, directly derived from its crystal structure. Through high-quality structure analyses using neutron and X-ray diffraction, combined with first-principles calculations, we have been fabricating materials with desired functions. To date, more than 40 novel materials have been discovered based on our guiding principles.
実用化イメージ

For developing future device technologies, challenges on thin-film thermionic multilayers and organic thermoelectric materials are currently underway.

Researchers

Graduate School of Engineering

Yuzuru Miyazaki

[peptide]

Peptide and Protein Designs for Unexplored Fileds

 
 
 
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特徴・独自性
  • I am proposing methodologies to design recombinant peptides and proteins with appropriate structures and functions in the medicinal, environmental, material, and nanotechnological fields, with molecular evolutional and domain shuffling engineering. At present, we have constructed the methodologies for efficient renaturation of functional proteins from inclusion bodies expressed in bacteria, generation of peptides and proteins with the function of biomineralization, generation of peptides and proteins with affinity for inorganic materials to spontaneously make linkages between various nanomaterials, and high enhancement of cellulolytic enzyme activity induced by nanoclustering design on nanomaterials.
実用化イメージ

We hope the business partners in the in the medicinal, environmental, material, and nanotechnological fields would be interested in my approaches and we could conduct effective collaboration research with them.

Researchers

Graduate School of Engineering

Mitsuo Umetsu

Peptide formation under high P and T conditions: new carbon fibers

 
 
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特徴・独自性
  • Peptides are formed through the enzymatic actions in living organisms, but difficulty exists to form peptide by non-enzymatic actions. Here we report the success of peptide formation under anhydrous, high P and T conditions. We were successful to form 11-mer of glycine and 5-mer of alanine. They are important constituents of spider silk, which is a candidate of next generation of carbon fibers. Therefore, our techniques have potentials to apply making new carbon fibers without biotechnology.
実用化イメージ

Researchers

Graduate School of Science

Takeshi Kakegawa

[Periodontal disease]

Oral Biofilm Functional Analysis: from “What Are They?" to “What Are They Doing?"

 
 
 
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特徴・独自性
  • A large number of microorganisms inhabit the oral cavity, such as the teeth, gingiva and tongue, in the form of oral biofilm. The oral cavity forms an ecosystem where the host (humans) and parasites (microorganisms) coexist. Disruption of the balance of this oral ecosystem leads to dental caries, periodontal diseases and oral malodor, and even deterioration of dental materials.
  • Using leading-edge techniques of anaerobic experimental systems including original and unique devices, as well as the notion of "omics" such as metagenomics and metabolomics, we conduct research on oral biofilm functions. Knowledge of oral biofilms, from "what are they?" to "what are they doing?", enables us to address their control, that is, prevention of and therapy for oral biofilm-associated diseases.
実用化イメージ

Risk assessment of oral biofilm-associated diseases, such as dental caries, periodontal disease, oral malodor and aspiration pneumonia
Effects of medicine and food ingredients on oral biofilm function
Evaluation of biofilm-mediated material deterioration

Researchers

Graduate School of Dentistry

Nobuhiro Takahashi

[peripheral circulation]

The Novel Ultrasound Irradiation Device

 
 
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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

Research Profiles

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