Tohoku University. Research Profiles

LANGUAGE

"P" Keywords - 101 Result(s)

P

 P

[prevention of atherosclerosis]

Analysis of Function of Functional Food Components Preventing Atherosclerosis

NEXT
PREV
Features

We have much experience on basic studies including experimental animal research on improvement of lipid metabolism and prevention of obesity by functional food components. Causes of obesity and abnormality of lipid metabolism are complex, and measurement of enzyme activity and gene expression does not necessarily give us the precise information on mechanisms of improvement of lipid metabolism and prevention of obesity by food components.

Targeted Application(s)/Industry

Based on our experience, we are prepared to provide academic consultations to companies interested in our research. In some situations, we can conduct effective collaborative research in this field.

Food Function and Health, Graduate School of Agricultural Science
IKEDA Ikuo, Professor Doctor of Agriculture

[Prevention of Fractures]

Prediction and Prevention of Fractures

NEXT
PREV
Features

We have been developing methods for explicating the dominant factors that determine the physical and chemical properties of materials and stacked structures used in human societies. Since the number of element atoms which consists of advanced materials has been increasing, and the crystallographic structure of the materials has become very complicated, both the various properties and reliability of the materials fluctuate significantly in nano-scale, and thus, deteriorate easily due to the local damages of the materials.

Targeted Application(s)/Industry

To design the optimal structure, composition of materials, and the fabrication process of both materials and stacked structures, we are going to develop a method of analyzing the atomic structure of thin film materials based on quantum mechanics and experimental methods for measuring material properties, atomic scale damage or defects in nano-materials.

Fracture and Reliability Research Institute, Graduate School of Engineering
MIURA Hideo, Professor PhD., Dr. of Engineering

[preventive medicine]

Quantitative Evaluation of the Baroreflex Sensitivity of the Heart and Artery

NEXT
PREV
Features

Metabolic syndrome is an important view point, when we consider the preventive medicine. Hypertension is one of the most important points to prevent the cardiovascular events. However, there is no method to measure the baroreflex sensitivity of the artery in the patients with hypertension. Tohoku University had invented the new method to evaluate the baroreflex sensitivity of the heart and artery (JP Patent No.4789203).

Targeted Application(s)/Industry

By the use of this machine, the baroreflex sensitivity of an artery in the patients can easily be measured noninvasively. It enables to predict the occurrence of hypertension and evaluate the therapy of hypertension easily, while allowing prevention of the cardiovascular events.

Institute of Development, Aging and Cancer
YAMBE Tomoyuki, Professor

[printing process]

Advanced Technology on Flexible Liquid Crystal Displays

NEXT
PREV
Features

Flexible liquid crystal displays using thin plastic film substrates instead of glass substrates contained in current liquid crystal displays, are bendable, thin, lightweight, and do not crack, and generate new usage styles and human interfaces due to their excellent storability and portability. We have been researching the basic technologies for large-screen and high-quality flexible displays using functional organic materials including liquid crystal and polymer, so that anyone can enjoy fertile information services.

Targeted Application(s)/Industry

We hope to conduct collaborative research with a willing company in industry, for development and practical application of the advanced flexible display technologies.

Department of Electronic Engineering, Graduate School of Engineering
FUJIKAKE Hideo, Professor Ph. D.

[Privacy]

Blockchain-based Approachs for High Secure P2P-type Decentralized Cloud Storage and Practical Smart Contract for Trading Personal Data

NEXT
PREV
Features

We are developing a decentralized P2P (Peer to Peer) type cloud storage that realizes innovative level of security by use of surplus storages of P2P nodes with the Blockchain technology. The developed storage can avoid the risk of large-scale information leakage of stored data due to the weakness of the central server. By using our cryptographic currency for rewards and usage fees in the storage, fair storage usage of all users can also be achieved.
In addition, We are developing a unique smart contract technology for practical decentralized trading of personal data among an unspecified number of users.

Targeted Application(s)/Industry

We hope to conduct collaborative researches with companies developing Bitcoin 2.0 type application (e.g. smart contract, Fintech) based on the Blockchain technology, the Internet of Things (IoT) technology, Medical Database for practical use.

Center for Information Technology in Education
SAKAI Masao, Associate Professor Doctor of Engineering

[probe synthesis]

Synthesis of Biologically Active Cyclodepsipeptide Natural Products

NEXT
PREV
Features

Cyclodepsipeptide natural products include optically active hydroxy acids as well as various unnatural amino acids and exhibit a variety of biological activity depending on the peptide sequence, chirality, and selection of the hydroxy acids. Structure-activity relationships of a synthetic library of natural products could give us significant information of not only biologically important moieties but also intact positions in the biologically active small molecules. On the basis of the former information, more potent compounds and/or peptide mimetics can be designed. The latter information can also be important for making a molecular probe that is used for exploration of a target molecule.

Targeted Application(s)/Industry

We study for combinatorial synthesis of natural product analogues using solid-phase.

Graduate School of Pharmaceutical Sciences
DOI Takayuki, Professor Doctor of Engineering

[Probiotics]

newGastroenteritis virus-binding enteric bacteria for probiotics

NEXT
PREV
Features

We have found enteric bacteria that can capture gastroenteritis viruses, such as norovirus and rotavirus, through histo-blood group antigen (HBGA)-like substances. These HBGA-positive bacteria give a significant impant on the ecology of gastroenteritis viruses in human body and in environments.

Targeted Application(s)/Industry

Since gastroenteritis virus-binding bacteria can affect the viral infection capability to host cells, these bacteria and produced HBGA-like substances are available in probiotics application.

Graduate School of Engineering, Tohoku University
Sano Daisuke, Professor PhD

[Process equipment]

Development of Advanced Device and Process Technologies and New Image Sensors

NEXT
PREV
Features

Toward the ultimate performances of image sensors, advanced research activities are being conducted that cover a wide range of technology fields from cleanroom infrastructure, materials, process equipment, process, device, circuit, assembly, signal processing, measurement/evaluation and reliability. Following technologies have been successfully commercialized:
A fast and accurate measurement technology of electrical characteristics for over 1 million transistors
A wide dynamic range CMOS image sensor technology capturing images over five decade brightness ranges
An ultra-fast CMOS image sensor technology with 10 million frames/sec

Targeted Application(s)/Industry

Followings are available for industry collaborators:
A. 200mm-diameter-wafer silicon device fabrication utilizing the ultra-clean facility including wafer mutual fabrication processing between device manufacturers.
B. Process technology development and various kinds of analyses.
C. Development of new image sensors.

Management Science and Technology, Graduate School of Engineering
SUGAWA Shigetoshi, Professor PhD

[product usability]

Food Palatability, Product Usability, and Preference; An Approach from Psychology and Neuroscience.

NEXT
PREV
Features

My research interest is peoples' perception of external stimulus. Based on these researches and our knowledge, I can offer you an idea of the products that give consumers satisfaction. Also on the basis of psychological and neuro-scientifc experiences and knowledges, I can offer you a transdisciplinary approaches on human perception, cognition, emotion and decision making.

Targeted Application(s)/Industry

Marketing and developing of the products such as foods, beverages, fabric softeners, perfumes, body deodorants etc. The knowledges and research tools are also useful in regulating the malodor in the air pollution, in developing the public services and in elevating public quality of life.

Department of Psychology, Graduate School of Arts and Letters
SAKAI Nobuyuki, Professor PhD of Human Sciences

[Programming Languages]

Programming Language Theory and Computation Models

NEXT
PREV
Features

Our laboratory conducts leading research on programming language theory and high-level computation models. In particular, we focus on research and application of (general proof methods for) program equivalence, functional programing, and type systems (also known as lightweight formal methods), which are attracting revived interests in recent years. Our Japanese translation of "Types and Programming Languages" (Benjamin C. Pierce, University of Pennsylvania)---compiled in cooperation with engineers from top-level electronics and software companies in Japan---has become the 42nd bestseller (rather exceptional as an academic Publications) among new books in Amazon.co.jp. For more information, please see the Web page: http://www.kb.ecei.tohoku.ac.jp/~sumii

Targeted Application(s)/Industry

Our technology can be used for design and development of software artifacts, especially programming languages and tools including DSL (domain specific languages), as well as application of functional programming, type systems, or formal methods.

Graduate School of Information Sciences
SUMII Eijiro, Professor

[Programming Models]

Supercomputing for enabling large-scale advanced simulations

NEXT
PREV
Features

As modern supercomputers are getting larger and more complicated, it is not so easy to exploit their potential performance. It is necessary to develop a simulation code with considering various factors for both hardware and software reasons, and hence expert knowledge and experiences about supercomputing are often needed to achieve high actual performance. Our research interests focus on shaping future supercomputing systems and their applications, especially system software technologies for effectively using the future supercomputers. Also we are always exploring how to make good use of the state-of-the-art hardware and software technologies in order to enable unprecedented-scale and more advanced simulations.

From beginning (apply for use of our supercomputer) to end (get a solution), we can consistently support developing large-scale practical simulation, which is feasible only by using the supercomputer. As a supercomputing center, we have a long history of parallelizing and accelerating a lot of practical simulation programs. In addition, we are looking for research collaborators who are interested in streamlining and/or facilitating large-scale scientific software development.

Targeted Application(s)/Industry

Cyberscience Center
TAKIZAWA Hiroyuki, Professor Doctor of Information Science

[Prolyl hydroxylase]

Development of PHD-Targeted Drug for Ischemic Injury

NEXT
PREV
Features

All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.

Targeted Application(s)/Industry

Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Division of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine (ART), Graduate School of Medicine
MIYATA Toshio, Professor M.D., PhD

[protein]

A novel crystal growth via controlling an energy relationship between crystal and melt with applying an electric field

NEXT
PREV
Features

This lab is concerned with the novel approach mainly for the growth from melt by studying the relationship between the interface dynamics during growth and properties of grown crystals. Special interests lie in the growth of new crystals via the imposition of an interface-electric field. Nano-scaled control of crystal growth is executed in an electric double layer of ~nm thickness that is induced by applying an external electric field on the growth interface. Some of our growth results brought by applying an electric field are;
1. Growth of Langasite-type crystals for the pressure sensor at high temperature by manipulating the energy relationship between crystal and melt.
2. Easy nucleation of protein crystals that are normally hard to crystallize.
3. Formation of Si crystals with desired structure by manipulating the interface instability of Si.
Crystals developed this way will widen an opportunity to collaborate with industries in the field of the piezoelectric, magnetic, optic and other fields related to the highly-networked information society.

Institute for Materials Research
UDA Satoshi, Professor Ph.D.

[protein labeling]

Imaging and photoregulation of biological functions

Features

To properly understand the functions of biomolecules, it is essential to observe them under physiological conditions where the interactions with other biomolecules are preserved. Therefore, we are developing new functional molecules using both organic chemistry and protein science approaches, and working on the visualization and optical control of biomolecules and their functions. Especially, we have developed fluorescent probes that quantitate the concentration of biomolecules or ions in subcellular regions such as organelles and caged compounds and photoswitches that optically manipulate the biomolecular functions.

Institute of Multidisciplinary Research for Advanced Materials
MIZUKAMI Shin, Professor Ph.D.

[proteolytic enzymes]

Development of Production System of Valuable Proteins Using a Koji-Mold, Aspergillus Oryzae, as a Host

Features

Because a koji-mold, Aspergillus oryzae, has an ability to secret a higher amount of proteins and is regarded as a safe microorganism, it has been expected as a promising host for production of useful proteins derived from plants and animals. However, Aspergillus oryzae produces various proteolytic enzymes that could degrade heterologous proteins produced, and hence we constructed mutant strains in which a transcription factor gene involved in proteolytic enzyme production was disrupted. In addition, codon optimization of heterologous gene resulted in a significant increase in the stability of heterologous gene transcripts. These attempts would lead to an increase in the amount of valuable proteins produced.

Targeted Application(s)/Industry

The technology could be applied to the high-level production of pharmaceutical proteins and industrially useful enzymes. We look forward to developing the collaborative project with enzyme and pharmaceutical industries.

Graduate School of Agricultural Science
GOMI Katsuya, Professor PhD

[Proton]

Quantum and Molecular Dynamic Simulations of Transport Phenomena in Fuel Cell

NEXT
PREV
Features

It is necessary to grasp nanoscale transport phenomena of materials in polymer electrolyte fuel cell to improve its performance. In our laboratory, nanoscale transport phenomena are analyzed by large scale molecular dynamics simulations using a supercomputer system. As the present theme, the dependence of the materials or structures of polymer electrolyte membrane on the ability of proton transfer(Fig. 1), the ability of proton transfer or oxygen permeability of ionomer in catalyst layer(Fig. 2), and the mechanism of transport phenomena of a water droplet in a nano pore in gas diffusion layer or micro porous layer(Fig. 3), are analyzed in detail.

Targeted Application(s)/Industry

These research can be applied to the analysis of flow field in devices which have nanoscale structure, for instance, fabrication process of semiconductor, friction phenomena of such nanoscale devices or next generation batteries, as well as the field of fuel cell.

Quantum Nanoscale Flow Systems Laboratory, Institute of Fluid Science
TOKUMASU Takashi, Professor Doctor of Engineering

[Pseudomonas aeruginosa]

Novel high-throughput screening systems for new antibiotics targeting bacterial virulence factors

NEXT
PREV
Features

Chemotherapy toward bacterial infection, which dates back to the discovery of penicillin, opened up the golden era of antibiotics. Thereafter, various clinically important antibiotics were introduced into the clinic, and hence serious bacterial infectious diseases were eradicated. However, this ephemeral hope has been disappearing due to the emergence of antibiotic resistant pathogens toward every new antibiotics launched into the clinic, such as multidrug-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA). To combat these life-threatening pathogens, there is a pressing need to develop new antibiotics. However, new antibiotics discovered in the future will be nullified by development of resistance to these antibiotics, since their targets are essential for bacterial survival. From this aspect in which inhibitors of the essential functions inevitably select resistant mutants, bacterial virulence could be a fascinating target for developing new antibiotics, because virulence attenuators are thought to be less likely to generate resistance. We focus on a novel protein translocation system, Tat, since this system appears to be involved in several aspects of bacterial virulence and is not present in mammalian cells, and iron-metabolism-associated system as novel targets for development of their inhibitors. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Agriculture
YONEYAMA Hiroshi, Professor Ph.D. (Doctor of Medicine)

[public policy]

Economics of Aging

Features

I investigate on the economics of aging, the optimal social welfare policy, low fertility and so on not based on the historical and systematic approach but based on the neo-classical economic theory. I also use econometric method and statistical approach. I often estimate the future projections of the population, public finance, magnitude of private markets, the results of public policies.
I also research on the comparative studies on East Asia (Japan, China, Korea, Taiwan) and European (especially Scandinavian countries). I provide statistic data and information on the economic and political systems on the aging in Japan.

Targeted Application(s)/Industry

The future estimation on the financial status , market caused by low fertility and aging. The effective management of the medical institutions, social welfare systems, gender equality societies for the central and local government, research institutions, public enterprises, and financial Institutions.

Graduate School of Economics and Managemant
YOSHIDA Hiroshi, Professor

[pulse laser]

Spintronics Devices and Materials

NEXT
PREV
Features

Spintronics is a technology utilizing electron spin which provided magnetic sensor, nonvolatile magnetic memory, and so on. Our studies are as below.

Noble & Rare-earth free magnetic films with large perpendicular magnetic anisotropy. We achieved to develop various Mn-bases alloy films exhibiting high perpendicular magnetic anisotropy (Fig.1 ).
THz range observation of magnetization motion. We achieved to detect a motion of magnetization using pulse laser in time domain (Fig. 2).
Novel organic spin devices. We achieved to fabricate hybrid junction consisting of an organic layer sandwiched by two inorganic magnetic layers and to observe magnetoresistance effect.
Tunnel Magnetoresistive devices: We are developing TMR devices with Mn-Ga alloys films (Fig.3 ).

Targeted Application(s)/Industry

Magnetic memory and storage. Microwave and Terahertz wave. Magnetic sensors.
We hope to conduct collaborative research with a willing company for a practical application of these devices and materials in industry.

WPI Advanced Institute for Materials Research
MIZUKAMI Shigemi, Professor Doctor of Engineering

[PVA]

Biomodel for Development of Endovascular Treatment

NEXT
PREV
Features

We perform in-vitro or computational researches for development of medical devices. We develop a model of artery or bone to evaluate medical devices. And we apply optimization way for development of medical devices. Our main target is, currently, stent, or catheter.

Targeted Application(s)/Industry

Our collaboration company can be; medical equipment, device, medical image, MEMS, standardization, medical training, or polymer.

Institute of Fluid Science
OHTA Makoto, Professor Doctor of Engineering