"S" Keywords - 158 Result(s)

 S

[superspace group]

Development of Potential Thermoelectric Materials

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特徴・独自性
  • We have been exploring novel thermoelectric materials. Functions of a solid substance primarily depend on the electronic structure, directly derived from its crystal structure. Through high-quality structure analyses using neutron and X-ray diffraction, combined with first-principles calculations, we have been fabricating materials with desired functions. To date, more than 40 novel materials have been discovered based on our guiding principles.
実用化イメージ

For developing future device technologies, challenges on thin-film thermionic multilayers and organic thermoelectric materials are currently underway.

Researchers

Graduate School of Engineering

Yuzuru Miyazaki

[Supply Chain Risk]

Visualization of supply chain risks from the resource logistics perspective

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特徴・独自性
  • With the increased global concerns of resource and environmental constraints of recent years, the role of mining, as a constituent of social responsibility associated with resource extraction and usage, is becoming increasingly important in the science, technology, and innovation policy. Under increasing public and shareholders' concerns of social and environmental sustainability, the fabrication industries require careful attention owing to their own risks related to the resources and materials that are used in their products and services. The Material Flow Analysis tool and Input output technique provide useful perspectives and valuable evidences for avoiding or minimizing the social and environmental risks related to the demand of resources.
実用化イメージ

Our developed model evaluates the risk weighted flow analysis by combining the resource logistics database and Global Link Input Output model. The estimated results shed light on how resource logistics prepares policy makers and R&D engineers to confront the risks behind resource usage and how the information should be shared among the stakeholders.

Researchers

Graduate School of Environmental Studies

Kazuyo Matsubae

[Support system software]

MEDICINE DETERMINATION SUPPORT SYSTEM AND MEDICINE DETERMINATION SUPPORT PROGRAM

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特徴・独自性
  • AIMS: This invention is to support the doctor’s prescription for diabetes and metabolic syndrome, especially in Japanese Clinic (Patent: JP 4176438).
  • PROBLEM TO BE SOLVED: To perform a further efficient preparation by providing information for original medicine and generic medicine in the preparation.
  • SOLUTION: The medicine price, pharmacologic effect and the like of each of original medicine and generic medicine are preliminarily recorded in a medicine database, and a generic medicine corresponding to the original medicine inputted by a doctor is automatically retrieved and displayed on a display. When the total number of the inputted medicine exceeds a number determined by insurance medical care, the generic medicine is retrieved so that the drug price of the group of the same usage is a prescribed amount or less. Welcome to your investment or co-operation.
実用化イメージ

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[suppressing tumorigenesis]

DIFFERENTIATION INDUCING METHOD ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

特徴・独自性
  • The present invention relates to a technique for differentiating iPS cells into target differentiated cells while suppressing tumorigenesis in the iPS cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.
実用化イメージ

Researchers

Graduate School of Dentistry

Hiroshi Egusa

[Surface]

Molecular Dynamics Analysis of Coating and Surface Modification

特徴・独自性
  • Molecular-scale mechanism of solid-liquid affinity, wettability, thermal boundary resistance and molecular deposition are analyzed by molecular dynamics simulations toward its control. With a background of heat and mass transport and interfacial thermodynamics, transport phenomena of various scales ranging from spin coating of photoresist to SAM (self-assembled monolayer) and hydrophobic/hydrophilic treatment by attaching some molecular basis are studied. Futhermore, the molecular-scale mechanisms which determine thermophysical properties and the molecular structure that realizes desired thermophysical properties are studied. We can conduct effective collaboration and provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Tohoku Medical Megabank Organization

Taku Obara

[Surface Forces]

Development of Nano-Interface Chemistry for Materials Sciences Using Surface Forces Measurement

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特徴・独自性
  • Our research aims at developing methods, including instrumentation, for characterizing surface (or interface) at the nano-meter level. Most of our research subjects are related to the surface forces measurement, which can directly monitor the interaction between two surfaces. We study phenomena occurring at the solid-liquid interface such as adsorption and structuring of liquids. We have developed the resonance shear measurement which is a sensitive method for evaluating properties of confined liquid for nano-rheology and tribology. Twin-path surface forces apparatus we developed enabled us to study wide variety of samples such as metals, ceramics and plastics.
実用化イメージ

These methods are applicable for characterizing lubricants, nano-materials, paints, sealants, and cosmetics. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

New Industry Creation Hatchery Center

Kazue Kurihara

[surface hardening]

Advanced Control of Microstructure and Property of Structural Metallic Materials

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特徴・独自性
  • Microstructure represents various kinds of heterogeneities in the metallic materials, i.e., grains, component phase, lattice defects and chemical inhomogeneity such as impurity/alloying elements. It can be modified through control of phase transformation/precipitation and deformation/recrystallization by adjusting compositions of materials and/or through processing routes (heat treatment, deformation). Such expertise in micro/nanostructure control is very important in production of current materials from viewpoints of energy saving and recycling in structural materials such as steels and titanium alloys.
  • We attempt to apply more advanced control of micro/nanostructures, such as atomic structures of crystalline interfaces, chemistory in an atomic scale (e.g., segregation) and so on. Fundamentals of microstructure formation (thermodynamics, kinetics, crystallography) are examined both theoretically and experimentally to clarify key factors for microstructure control. Another important aspect in our research is the improvement of mechanical property by microstructure manipulation.
実用化イメージ

Possibilities to establish new functions (e.g., superplasticity, shape memory/superelasticity) as well as superior mechanical properties (e.g., ultrahigh strength with high toughness/ductility) is also explored.

Researchers

Institute for Materials Research

Tadashi Furuhara

[surface metrology]

Development of Sensors and Measuring Systems for Ultra-Precision Manufacturing and Nanomanufacturing

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特徴・独自性
  • The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines, which are important items for ultra-precision manufacturing and nanomanufacturing. Optical sensors are being developed for measurement of angle and displacement, which are fundamental quantities for manufacturing. Technologies for improvement of the sensor sensitivity and bandwidth, reduction of the sensor size as well as new multi-axis sensing methods are being The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines. Optical sensors are being developed for measurement of angle and displacement. A number of scanning-type measuring systems for precision measurement of surface forms and stage motions are also being developed. Error separation algorithms and systems for straightness and roundness, which are the most fundamental geometries treated in ultra-precision manufacturing, are being investigated. Novel systems based on scanning probe microscopy are under development for micro- and nano-structures as well as freeform optics in responding to new and important challenges from ultra-precision manufacturing and nanomanufacturing.
実用化イメージ

The multi-axis optical displacement and angle sensors developed in the laboratory are expected to measure motions of semiconductor/IC manufacturing and inspection equipment, precision machine tools, ultra-precision measuring instrument. The surface profile measurement systems are expected t play an important role in ultra-precision manufacturing and nanomanufacturing industries.

Researchers

Graduate School of Engineering

I Ko

[Surface Modification]

Cavitation Peening

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特徴・独自性
  • Surface modification method to improve fatigue strength has been developed using cavitation impacts, which are normally causes severe damage in hydraulic machineries. The method was called "cavitation peening". In order to make clear the mechanism, a load controlled plate bending fatigue test machine was developed. It was proved by using the test machine that the threshold level of stress intensity factor was improved about 1.9 times by cavitation peening. The mitigation of hydrogen embrittlement by cavitation peening was also improved.
実用化イメージ

The cavitation peening can apply to component of automobile and forging die. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Hitoshi Soyama

[Surface science]

Surface scientific approach for developments in fuel cell's catalysts

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特徴・独自性
  • From catalytic perspective, molecular-level understanding of surface phenomena occurring at nano-sized metal (alloy) particle surfaces is a key for developing highly active and durable catalysts. Our experimental approach for studying catalysis is preparations of well-defined metals or alloy surfaces by using ultra-high vacuum (UHV) and molecular-beam-epitaxy (MBE) techniques. We routinely use UHV-MBE, surface vibrational spectroscopy (IR, Raman), scanning probe microscopy (SPM), electron spectroscopy (XPS), electrochemical (EC) voltammetry, gas-chromatography (GC) etc., and try to clarify the solid surface phenomena on atomic, molecular-levels. We believe our research results directly link to future eco-friendly society.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Toshimasa Wadayama

[Sustainability]

Study on Land Use Management and Residential Movement in Tsunami Affected Areas

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特徴・独自性
  • The study focused on areas affected by the tsunami caused by the Great East Japan Earthquake, and clarified the impact of reconstruction projects on spatial transformation and residents' residential relocation, as well as residents' satisfaction with the projects. In the boundary area of architecture, urban planning, and landscape architecture, we combine qualitative research, such as participatory observation with sociological and local community perspectives, and quantitative research using data obtained in the field. I would like to explore better relationships between people and nature, and propose methods that lead to sustainable urban development.
実用化イメージ

I have practical experience in post-disaster land use and workshops with local residents. I believe that they will be able to make use of their knowledge and experience in the pre-disaster reconstruction efforts in the areas that are expected to be affected by the disaster in the future.

Researchers

Graduate School of Engineering

Shoko Araki

[Swine]

Development of Immunobiotic Evaluation System for Functional Feeds as a Livestock Animal Model

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特徴・独自性
  • Pattern recognition receptor (PRR) family plays an important role in the defense through recognition of pathogen-associated molecular patterns or microorganisms-associated molecular patterns (PAMPs/MAMPs).
  • Some functional feed materials are thought to regulate intestinal immunity by contact and stimulation of epithelial cells and immunocompetent cells via PRRs in the gastrointestinal tract and induction of cytokine production. In this "new world" of feed immunology, however, much remains unknown about the underlying mechanisms of intestinal immunity because of lack of appropriate intestinal immunoassay system for livestock animals.
  • We have advanced application of originally established porcine and bovine intestinal epitheliocytes (PIE, BIE) cell lines (see photo) for evaluation of immunobiotics and immunogenics exerting anti-inflammatory responses both in PIE cell monolayer and co-culture system with porcine peyer's patch immune cells as a peyer's patch culture model (see illustration).
実用化イメージ

This evaluation system may also contribute to elucidate immunoregulatory mechanism of immunobiotics and immunogenics mediated by pattern recognition receptors essential to future development of not only immunobiotic feeds but also vaccines using immunobiotics to prevent specific diseases. This can benefit mankind by offering immunobiotic feeds as a safer alternative to conventional antibiotic drug therapy.

Researchers

Graduate School of Agricultural Science

Haruki Kitazawa

[synchrotron radiation]

High-speed X-ray phase tomography with a millisecond-order temporal resolution

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特徴・独自性
  • We successfully realized millisecond-order X-ray phase tomography using a fringe-scanning method in grating-based X-ray interferometry. We obtained phase tomograms with a measurement time of 4.43 ms using a white synchrotron X-ray beam. The use of a fringe-scanning method enables us to achieve not only a higher spatial resolution but also a higher signal-to-noise ratio than that attained by the Fourier transform method. In addition, our approach can be applied to realize four-dimensional or high-throughput X-ray tomography for samples that can be rotated at a high speed.
実用化イメージ

Researchers

International Center for Synchrotron Radiation Innovation Smart

Wataru Yashiro

[Synthetic Medicines]

Advanced Molecular Transformations by Organocatalysts

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特徴・独自性
  • The development of organic molecules which function as a catalyst has been extensively investigated to achieve selective and efficient transformation of organic molecules. Brønsted acids and bases are commonly employed as the catalyst in synthetic organic chemistry. To aim at their functionalization, axially chiral phosphoric acids and axially chiral guanidine bases have been developed as chiral Brønsted acid and base catalysts, respectively. A variety of optically active compounds has been synthesized through the development of highly stereoselective reactions using these catalysts.
実用化イメージ

The development of chiral Brønsted acid and base catalysts has been accomplished as recoverable and reusable organocatalysts and highly stereoselective molecular transformations have been established using these catalysts. The present methodology is applicable to process chemistry in preparing medicines and relevant compounds on the basis of the selective and efficient molecular transformations thus developed with reduction of the waste material.

Researchers

Graduate School of Science

Masahiro Terada

[Synthetic Organic Chemistry]

Development of New Reactions Using Organocatalyst

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特徴・独自性
  • Organocatalyst is a synthetically useful catalyst in synthetic organic chemistry, because of the several merits. We have been investigating the development of new and efficient organocatalysts derived from proline. We have already reported the diphenylprolinol silyl ether, which is called as a Jorgensen-Hayashi catalyst, and siloxyproline, which is effective in the presence of water. We have also developed several practical asymmetric catalytic reactions based on the organocatalysts. We also applied these reactions to the total synthesis of natural products and drugs. We have already synthesized Tamiflu in one-pot reaction, and prostaglandin E1 methyl ester via three one-pot procedure.
実用化イメージ

Our newly developed reactions using organocatalysis can be widely used for synthesis of medicines, agrichemicals, and chemical products.

Researchers

Graduate School of Science

Yujiro Hayashi

[system design]

Theory and practice of energy design to drive decarbonization

概要

An indispensable function for decarbonized driving is energy data analysis, an energy car navigation system with both high spatial and temporal resolution. Higher spatial resolution facilitates the recharging and discharging of electric cars and inter-regional energy exchange. With the addition of up-to-the-minute energy data with high temporal resolution, it is possible to rationally and optimally combine the fluctuating output of renewable energy with the consumers. Data analysis, system design, and operation will lead to a carbon-neutral society.

従来技術との比較

Japan's first regional energy supply and demand database has been developed, allowing for detailed design of sustainable and resilient regional energy infrastructure layout and operation based on analysis of the current energy status of cities, towns, and villages nationwide.

特徴・独自性
  • Research experience as a Fulbright Scholar in the U.S. and familiarity with examples of social implementation in Europe.
  • Data-driven innovation research approach based on a vast regional energy supply and demand database.
  • Emphasis on regional fieldwork as a social entrepreneur solving social issues.
実用化イメージ

Putting Theory into Practice. Helping to build sustainable energy systems for new community development. Including the background of the local community, listening to the opinions of the residents, and guiding them to discussions that are relevant to today's issues. Thinking globally and acting within the community.

Researchers

Graduate School of Engineering

Toshihiko Nakata

[systemic chemotherapy]

Development of an intranodal administration method

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特徴・独自性
  • (1) The amount of anticancer drug required to treat one metastatic lymph node is 1/1,000 to 1/10,000 of the systemic dose.
  • (2) The drug can be administered into the lymph node under ultrasound guidance.
  • (3) An international patent has been filed for the solvent of the administered drug.
実用化イメージ

1. Treatment and prophylactic therapy of affiliated lymph nodes in head and neck cancer, breast cancer, etc.
2. Pharmaceutical companies aiming to develop drugs by drug repositioning and generics
3. Medical device manufacturers aiming to develop a dosing system

Researchers

Graduate School of Biomedical Engineering

Tetsuya KODAMA