"S" Keywords - 161 Result(s)
S
[Saccharomyces cerevisiae]
Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulatorsFeaturesUsing the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42. Targeted Application(s)/IndustryOur yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry. Graduate school of Agricultural Science
FUTAI Eugene, Associate Professor
Doctor of Agriculture
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[Safety design]
Combustion and Atomization Technology in High-Pressure Gas Turbine ConditionsFeaturesCombustion is a complex phenomenon composed of multi-dimensional dynamics of temperature, concentration, velocity, and chemical reactions. Advanced combustion technologies are essential for solving the environmental and energy issues. Our laboratory has a high-pressure combustion test facility which is a unique experimental facility in the world. Research projects have originality, especially in the field of high-pressure combustion and laser diagnostics, and focus on not only aerospace engineering and energy engineering including new fuel technology but also atomization technology and safety operations of chemical plants mostly operated at high pressure. Targeted Application(s)/IndustryPotential collaborations are in the research fields of aerospace propulsions, automobile engines, power generations and chemical plants, in terms of development of gas turbine combustors for various fuels, generation and control of fuel atomizers, laser diagnostics of combustion and safety design of chemical reactors. High Speed Reacting Flow Laboratory, Institute of Fluid Science
KOBAYASHI Hideaki, Professor
Doctor of Engineering
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[Sanskrit]
Religion, language, society, and life in ancient IndiaFeaturesTargeted Application(s)/Industry |
[SAR]
Radar Remote SensingFeaturesWe are developing new electromagnetic methodologies including radar and electromagnetic induction techniques, applying to natural resources survey and environmental monitoring. Currently, we are working for topics such as space borne and air borne microwave remote sensing sensors (SAR), Ground Penetrating Radar (GPR), Electromagnetic Induction methods (Metal detector) and their applications to subsurface sensing and humanitarian demining, and borehole radar for hydro geology. One of our sensors, ALIS which is a GPR system for land mine detection has been successfully operated in real mine field in Cambodia. These technologies using applied electromagnetics can be applied to other fields. We are seeking for industries which have interests in subsurface sensing and detection. Targeted Application(s)/Industry•Development and Application of Ground Penetrating Radar (GPR ) , EMI methods |
[SARS-CoV-2]
Development and evaluation of various inhibitors and disinfectants for SARS-CoV-2FeaturesUsing the infectious SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), we are evaluating and developing new therapeutic drug candidates as well as evaluating disinfectants. Further analyses such as mechanism of action and resistance may be applicable. Other pathogens, including influenza virus and drug-resistant bacteria, will be examined upon request and discussion. Through joint and collaborative research with domestic and overseas pharmaceutical companies and related companies, we have experience of their clinical application including basic research. Targeted Application(s)/IndustryWe support development and evaluation of various inhibitors and disinfectants for variants of SARS-CoV-2 as well as wild type. |
[satellite cells]
Induction of skeletal muscle cells from human mesenchymal stem cells and their application to muscle degenerationFeaturesBone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce skeletal muscle cells from human bone marrow stromal cells by treating cells with cytokines followed by Notch intracellular domain gene plasmid introduction. This induction system successfully generates skeletal muscle lineage cells comprised of muscle stem cells, namely, satellite cells, as well as myoblasts and myotubes. Transplantation of satellite cells and myoblasts were effective for muscle regeneration (Science, 2005). Importantly, induced satellite cells integrated into satellite cell location and continuously contributed to muscle regeneration. Our research team is now pursuing the safety and efficiency of these induced cells by using canine muscle degeneration models. We hope to collaborate with companies and research groups who are willing to utilize our system. Targeted Application(s)/Industry |
[Saving energy]
Photo-Induced Characteristics of TiO2 Prepared by Anodic OxidationFeaturesTi anodizing technique has been offered for coloring the surface of Ti, and its mechanism is understood by light interference varied with the oxide thickness. A characteristic of this study is to control the crystallinity of the oxide, and its originality is to provide photo-induced characteristics to Ti and its alloys by controlling the electrochemical conditions differed from that of coloration technology. This study is aimed for controlling the surface of Ti by using a simple and easy, inexpensive technique and to fabricate high functional titanium materials. Targeted Application(s)/IndustryRelated to practical applications, it is considered as a use for environmental purification such as deodorization and water purification, biomaterial and antibacterial and structural titanium. Institute for Materials Research
MASAHASHI Naoya, Professor
Doctor of Engineering
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[SAXS]
X-Ray Phase Imaging for High-Sensitive Non-Destructive TestingFeaturesConventional X-ray imaging methods that rely on X-ray attenuation cannot generate clear contrast in the observation of low-density materials such as polymers consisting of low-Z elements. However, the sensitivity to the materials can be improved drastically by X-ray phase imaging that detects X-ray refraction caused by the materials. X-ray Talbot or Talbot-Lau interferometry consisting of X-ray transmission gratings is now constructed in laboratories for X-ray phase imaging. X-ray phase tomography is also realized, enabling high-sensitive three-dimensional observation. Targeted Application(s)/IndustryWe aim at appending a phase-contrast mode to micro-CT apparatuses and developing screening apparatuses in production lines. Institute of Multidisciplinary Research for Advanced Materials
MOMOSE Atsushi, Professor
Dr.
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[scanning probe microscopy]
Biological Application of Scanning Probe MicroscopeFeaturesWe have invented a unique method to non-invasively evaluate the quality of individual mammalian embryos based on oxygen consumption. A Pt microelectrode was scanned near the single embryo sample to obtain oxygen concentration profile. Respiration activity of single embryo was estimated based on spherical diffusion theory. Further, it was found that the respiration activities of individual embryos corresponded the developmental potential of the embryos. Independently, we have developed a procedure of mRNA quantification from single-cell based on SPM featuring multi-functional probes. Next, we are going to combine the two methods mentioned above for quality control of mammalian embryos and embryonic stem cells. Targeted Application(s)/IndustryOur methods will be applied for assisted reprodictive technoloy (ART), pancreatic islet transplantation, or animal breeding. |
[SCC]
Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation TechniquesFeaturesThe emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding. Targeted Application(s)/IndustryThe method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for. Department of Quantum Science and Energy Engineering , Graduate School of Engineering
YUSA Noritaka, Professor
Doctor of Engineering
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[School Education]
ICT Use by Teachers and Students in the Classrooms of Elementary and Secondary SchoolsFeaturesMy research focuses on ICT use in the classrooms of elementary and secondary schools in Japan. Targeted Application(s)/IndustryMy research can be applied to a development of teaching support tools for elementary and secondary school teachers which can be used in the classroom and a consulting service to assist development of digital teaching materials for school students. |
[Science Communication]
Philosophy of Science and Technology, Science and Technology Studies (STS)FeaturesMy research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users. Targeted Application(s)/IndustryI hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction. |
[Scientific Simulation]
Supercomputing for enabling large-scale advanced simulationsFeaturesAs modern supercomputers are getting larger and more complicated, it is not so easy to exploit their potential performance. It is necessary to develop a simulation code with considering various factors for both hardware and software reasons, and hence expert knowledge and experiences about supercomputing are often needed to achieve high actual performance. Our research interests focus on shaping future supercomputing systems and their applications, especially system software technologies for effectively using the future supercomputers. Also we are always exploring how to make good use of the state-of-the-art hardware and software technologies in order to enable unprecedented-scale and more advanced simulations. Targeted Application(s)/Industry |
[scintillator crystals]
Development of Novel Scintillator and Piezoelectric CrystalsFeaturesOur research target is mainly focused on the topic of development of novel scintillator crystals, piezoelectric crystals, growth technology, characterization and its device application. Targeted Application(s)/IndustryFor the purpose of "real" contribution to human culture, we are always carrying out our research activity considering the industrial application. This point is unique feature of our attitude toward science. Research Laboratory on Advanced Crystal Engineering, Institute for Materials Research
YOSHIKAWA Akira, Professor
Doctor of Science
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[SDGs]
Prediction and evaluation of future thermal and wind environments based on CFD, and planning of urban environments adaptable to future climateFeaturesNumerical simulations of the physical environment of urban outdoor spaces are conducted to predict the physical environment, such as temperature, humidity, wind, and pollutant concentration, and field measurements are conducted to understand the actual physical environment. In addition, the future outdoor environments and heat stroke risks due to global warming are predicted and evaluated. Targeted Application(s)/IndustryNumerical analysis is used to quantitatively evaluate the "merits and demerits" of designing buildings, planning city blocks and urban areas, and introducing various heat control technologies on the wider thermal environment and the formation of wind ventilation paths, as well as the adverse effects of typhoons and other disasters. The materials for making decisions on whether or not to introduce these technologies are provided. Dept. of Architecture & Building Science Graduate School of Engineering, Tohoku University
ISHIDA Yasuyuki, Assistant Professor
Doctor of Engineering, Ph. D.
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[Secret sharing]
Blockchain-based Approachs for High Secure P2P-type Decentralized Cloud Storage and Practical Smart Contract for Trading Personal DataFeaturesWe are developing a decentralized P2P (Peer to Peer) type cloud storage that realizes innovative level of security by use of surplus storages of P2P nodes with the Blockchain technology. The developed storage can avoid the risk of large-scale information leakage of stored data due to the weakness of the central server. By using our cryptographic currency for rewards and usage fees in the storage, fair storage usage of all users can also be achieved. Targeted Application(s)/IndustryWe hope to conduct collaborative researches with companies developing Bitcoin 2.0 type application (e.g. smart contract, Fintech) based on the Blockchain technology, the Internet of Things (IoT) technology, Medical Database for practical use. Center for Information Technology in Education
SAKAI Masao, Associate Professor
Doctor of Engineering
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[secretion]
Development of Production System of Valuable Proteins Using a Koji-Mold, Aspergillus Oryzae, as a HostFeaturesBecause a koji-mold, Aspergillus oryzae, has an ability to secret a higher amount of proteins and is regarded as a safe microorganism, it has been expected as a promising host for production of useful proteins derived from plants and animals. However, Aspergillus oryzae produces various proteolytic enzymes that could degrade heterologous proteins produced, and hence we constructed mutant strains in which a transcription factor gene involved in proteolytic enzyme production was disrupted. In addition, codon optimization of heterologous gene resulted in a significant increase in the stability of heterologous gene transcripts. These attempts would lead to an increase in the amount of valuable proteins produced. Targeted Application(s)/IndustryThe technology could be applied to the high-level production of pharmaceutical proteins and industrially useful enzymes. We look forward to developing the collaborative project with enzyme and pharmaceutical industries. |
[security]
Blockchain-based Approachs for High Secure P2P-type Decentralized Cloud Storage and Practical Smart Contract for Trading Personal DataFeaturesWe are developing a decentralized P2P (Peer to Peer) type cloud storage that realizes innovative level of security by use of surplus storages of P2P nodes with the Blockchain technology. The developed storage can avoid the risk of large-scale information leakage of stored data due to the weakness of the central server. By using our cryptographic currency for rewards and usage fees in the storage, fair storage usage of all users can also be achieved. Targeted Application(s)/IndustryWe hope to conduct collaborative researches with companies developing Bitcoin 2.0 type application (e.g. smart contract, Fintech) based on the Blockchain technology, the Internet of Things (IoT) technology, Medical Database for practical use. Center for Information Technology in Education
SAKAI Masao, Associate Professor
Doctor of Engineering
|
[Seebeck effect]
Development of Potential Thermoelectric MaterialsFeaturesWe have been exploring novel thermoelectric materials. Functions of a solid substance primarily depend on the electronic structure, directly derived from its crystal structure. Through high-quality structure analyses using neutron and X-ray diffraction, combined with first-principles calculations, we have been fabricating materials with desired functions. To date, more than 40 novel materials have been discovered based on our guiding principles. Targeted Application(s)/IndustryFor developing future device technologies, challenges on thin-film thermionic multilayers and organic thermoelectric materials are currently underway. |
[seed]
Molecular studies on new resources for hybrid rice breedingFeaturesF1 hybrid breeding is one of the most advanced techniques for production of cultivars with higher yield and desirable traits of both parents. Most of hybrid rice utilize cytoplasmic male sterility (CMS) and fertility restoration system. We develop a Tohoku University-original CW-type CMS and fertility restorer line and study their molecular mechanism. The CW-type cytoplasm enables indica rice cultivars to be CMS, which could not be achieved by other known cytoplasm. Targeted Application(s)/IndustryHybrid rice has an average 30% yield advantage over inbred lines, and is cultivated on 13% of the world rice fields. Our study provides a new and original resource for hybrid rice breeding for globalization of rice industry. Graduate School of Agricultural Science
TORIYAMA Kinya, Professor
Doctor of Agriculture
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